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Gene Review

MMP9  -  matrix metallopeptidase 9 (gelatinase B,...

Sus scrofa

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Disease relevance of LOC654325


High impact information on LOC654325


Biological context of LOC654325


Anatomical context of LOC654325

  • The migration of macrophages into defects was prominent at two and eight days, with synthesis and deposition of matrix metalloproteinase-9 onto damaged cartilage matrix and newly synthesized matrix in the defect [8].

Associations of LOC654325 with chemical compounds

  • The matrix metalloproteinase-9 (MMP-9) activity increased by 30, 46, 12 and 23% after 3, 24, 48 and 72 h of HN2 exposure, respectively, whereas the MMP-2 was elevated by 8, 65, 8 and 30%, respectively [9].

Other interactions of LOC654325

  • Our objective was to investigate the role of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and their cellular sources in guinea pig asthma model following ovalbumin (OA) challenge [10].

Analytical, diagnostic and therapeutic context of LOC654325


  1. Overexpression of matrix metalloproteinase-9 promotes intravascular thrombus formation in porcine coronary arteries in vivo. Morishige, K., Shimokawa, H., Matsumoto, Y., Eto, Y., Uwatoku, T., Abe, K., Sueishi, K., Takeshita, A. Cardiovasc. Res. (2003) [Pubmed]
  2. Cigarette smoke exposure potentiates bleomycin-induced lung fibrosis in guinea pigs. Cisneros-Lira, J., Gaxiola, M., Ramos, C., Selman, M., Pardo, A. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
  3. Upregulation of prostaglandin E2 and matrix metalloproteinase 9 production by human macrophage-like cells: synergistic effect of capsular material and cell wall from Streptococcus suis. Jobin, M.C., Gottschalk, M., Grenier, D. Microb. Pathog. (2006) [Pubmed]
  4. Relaxin increases secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 during uterine and cervical growth and remodeling in the pig. Lenhart, J.A., Ryan, P.L., Ohleth, K.M., Palmer, S.S., Bagnell, C.A. Endocrinology (2001) [Pubmed]
  5. Keratinocyte growth factor stimulation of gelatinase (matrix metalloproteinase-9) and plasminogen activator in histiotypic epithelial cell culture. Putnins, E.E., Firth, J.D., Uitto, V.J. J. Invest. Dermatol. (1995) [Pubmed]
  6. Matrix metalloproteinase induction in post-transplant obliterative bronchiolitis. Eerola, L.M., Alho, H.S., Maasilta, P.K., Inkinen, K.A., Harjula, A.L., Litmanen, S.H., Salminen, U.S. J. Heart Lung Transplant. (2005) [Pubmed]
  7. Transforming growth factor-beta2 (TGF-beta2) reverses the inhibitory effects of fibrin sealant on cutaneous wound repair in the pig. Petratos, P.B., Felsen, D., Trierweiler, G., Pratt, B., McPherson, J.M., Poppas, D.P. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. (2002) [Pubmed]
  8. Immunolocalization of matrix metalloproteinases in partial-thickness defects in pig articular cartilage. A preliminary report. Hembry, R.M., Dyce, J., Driesang, I., Hunziker, E.B., Fosang, A.J., Tyler, J.A., Murphy, G. The Journal of bone and joint surgery. American volume. (2001) [Pubmed]
  9. Topical treatment with povidone iodine reduces nitrogen mustard-induced skin collagenolytic activity. Wormser, U., Brodsky, B., Reich, R. Arch. Toxicol. (2002) [Pubmed]
  10. Levels of matrix metalloproteinase-9 and its inhibitor in guinea pig asthma model following ovalbumin challenge. Tang, L.F., Du, L.Z., Zou, C.C., Gu, W.Z. Fetal and pediatric pathology. (2005) [Pubmed]
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