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Gene Review

FGF7  -  fibroblast growth factor 7

Sus scrofa

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Disease relevance of FGF7

  • The pattern of epidermal thickening observed in KGF-treated wounds resembled psoriasis [1].

High impact information on FGF7


Biological context of FGF7


Anatomical context of FGF7


Associations of FGF7 with chemical compounds

  • 17beta-Estradiol stimulated the expression of KGF (P < 0.05), whereas catechol estrogens had no effect (P > 0.05) [6].
  • To identify regions in KGF that contribute to heparin and tyrosine kinase receptor interactions, nine peptides spanning defined motifs in the predicted structure of KGF were synthesized, and their heparin and receptor binding properties were analyzed [7].
  • Heparin and heparan sulfate in combination with KGF may thus have important roles in the regulation of epithelial cell collagenase under conditions such as inflammation and wound healing [10].
  • In the operated ureter elevated expression of keratinocyte growth factor, vascular endothelial growth factor, TGF-alpha, TGF-beta 1, TGF-beta 3 and integrin was detected 2 hours after the operation and sustained for 7 to 14 days after the procedure [11].
  • CLA and n-3 PUFA acted synergistically to upregulate colonic KGF expression in DSS-challenged pigs but n-3 PUFA blocked CLA-induced PPAR gamma activation [12].

Other interactions of FGF7


Analytical, diagnostic and therapeutic context of FGF7


  1. Human keratinocyte growth factor effects in a porcine model of epidermal wound healing. Staiano-Coico, L., Krueger, J.G., Rubin, J.S., D'limi, S., Vallat, V.P., Valentino, L., Fahey, T., Hawes, A., Kingston, G., Madden, M.R. J. Exp. Med. (1993) [Pubmed]
  2. Collagenase-3 (matrix metalloproteinase-13) expression is induced in oral mucosal epithelium during chronic inflammation. Uitto, V.J., Airola, K., Vaalamo, M., Johansson, N., Putnins, E.E., Firth, J.D., Salonen, J., López-Otín, C., Saarialho-Kere, U., Kähäri, V.M. Am. J. Pathol. (1998) [Pubmed]
  3. Growth factors in porcine full and partial thickness burn repair. Differing targets and effects of keratinocyte growth factor, platelet-derived growth factor-BB, epidermal growth factor, and neu differentiation factor. Danilenko, D.M., Ring, B.D., Tarpley, J.E., Morris, B., Van, G.Y., Morawiecki, A., Callahan, W., Goldenberg, M., Hershenson, S., Pierce, G.F. Am. J. Pathol. (1995) [Pubmed]
  4. Genetic linkage mapping of the porcine fibroblast growth factor 7 (FGF7) gene. Kelly, K.A., Larsen, N.J., Rothschild, M.F. J. Anim. Sci. (1998) [Pubmed]
  5. Accelerated wound healing by in vivo application of keratinocytes overexpressing KGF. Kopp, J., Wang, G.Y., Kulmburg, P., Schultze-Mosgau, S., Huan, J.N., Ying, K., Seyhan, H., Jeschke, M.D., Kneser, U., Bach, A.D., Ge, S.D., Dooley, S., Horch, R.E. Mol. Ther. (2004) [Pubmed]
  6. Keratinocyte growth factor is up-regulated by estrogen in the porcine uterine endometrium and functions in trophectoderm cell proliferation and differentiation. Ka, H., Jaeger, L.A., Johnson, G.A., Spencer, T.E., Bazer, F.W. Endocrinology (2001) [Pubmed]
  7. Colocalization of heparin and receptor binding sites on keratinocyte growth factor. Kim, P.J., Sakaguchi, K., Sakamoto, H., Saxinger, C., Day, R., McPhie, P., Rubin, J.S., Bottaro, D.P. Biochemistry (1998) [Pubmed]
  8. Keratinocyte growth factor: expression by endometrial epithelia of the porcine uterus. Ka, H., Spencer, T.E., Johnson, G.A., Bazer, F.W. Biol. Reprod. (2000) [Pubmed]
  9. Keratinocyte growth factor and autocrine repair in airway epithelium. Hicks, W.L., Hall, L.A., Hard, R., Gardella, J., Bright, F., Parasharama, N., Lwebuga-Mukasa, J., Sigurdson, L. Arch. Otolaryngol. Head Neck Surg. (2004) [Pubmed]
  10. Stimulation of collagenase (matrix metalloproteinase-1) synthesis in histiotypic epithelial cell culture by heparin is enhanced by keratinocyte growth factor. Putnins, E.E., Firth, J.D., Uitto, V.J. Matrix Biol. (1996) [Pubmed]
  11. Comprehensive evaluation of ureteral healing after electrosurgical endopyelotomy in a porcine model: original report and review of the literature. Andreoni, C.R., Lin, H.K., Olweny, E., Landman, J., Lee, D., Bostwick, D., Clayman, R.V. J. Urol. (2004) [Pubmed]
  12. CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD. Bassaganya-Riera, J., Hontecillas, R. Clinical nutrition (Edinburgh, Scotland) (2006) [Pubmed]
  13. Sequence of keratinocyte growth factor and keratinocyte growth factor receptor orthologs [monkey, pig, rabbit]. Doyle, M.P., Morris, C.F., Biltz, R.E. In Vitro Cell. Dev. Biol. Anim. (1996) [Pubmed]
  14. Neonatal pig pancreatic duct-derived insulin-producing cells: preliminary in vitro studies. Basta, G., Racanicchi, L., Mancuso, F., Guido, L., Macchiarulo, G., Luca, G., Calabrese, G., Brunetti, P., Calafiore, R. Transplant. Proc. (2004) [Pubmed]
  15. Keratinocyte growth factor expression by the bovine corpus luteum. Salli, U., Bartol, F.F., Wiley, A.A., Tarleton, B.J., Braden, T.D. Biol. Reprod. (1998) [Pubmed]
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