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Gene Review

Nmnat1  -  nicotinamide nucleotide adenylyltransferase 1

Mus musculus

Synonyms: 2610529L11Rik, 5730441G13Rik, D4Cole1e, NMN adenylyltransferase 1, NaMN adenylyltransferase 1, ...
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Disease relevance of Nmnat1


High impact information on Nmnat1

  • Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene [2].
  • The chimeric mRNA is abundantly expressed in the nervous system and encodes an in-frame fusion protein consisting of the N-terminal 70 amino acids of Ufd2, the C-terminal 302 amino acids of D4Cole1e, and an aspartic acid formed at the junction [3].
  • Transfection of HEK293 cells with constructs comprising either full-length Nmnat-1 or the truncated Ube4b fragment (N70-Ube4b) demonstrated selective effects of Nmnat-1 (down-regulated pttg1) and N70-Ube4b (up-regulated edr1l-EST) on mRNA levels [4].
  • The delay in vincristine-induced neurite degeneration following lentiviral overexpression of Nmnat1 was significantly less potent than for Wld(S), and lentiviral overexpressed enzyme-dead Wld(S) still displayed residual neurite protection [1].
  • Whereas most NMN adenylyltransferase activity remained with the karyoplasts, glucose-6-phosphate dehydrogenase, ribonucleotide reductase, and thymidylate synthase were almost exclusively associated with the enucleated cytoplasts [5].

Biological context of Nmnat1


Anatomical context of Nmnat1


Associations of Nmnat1 with chemical compounds

  • There were no significant changes in NMNAT activity in response to MNNG treatment over 24 h, either in the presence or in the absence of NU1025 [8].

Regulatory relationships of Nmnat1


Analytical, diagnostic and therapeutic context of Nmnat1


  1. NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration. Conforti, L., Fang, G., Beirowski, B., Wang, M.S., Sorci, L., Asress, S., Adalbert, R., Silva, A., Bridge, K., Huang, X.P., Magni, G., Glass, J.D., Coleman, M.P. Cell Death Differ. (2007) [Pubmed]
  2. Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene. Mack, T.G., Reiner, M., Beirowski, B., Mi, W., Emanuelli, M., Wagner, D., Thomson, D., Gillingwater, T., Court, F., Conforti, L., Fernando, F.S., Tarlton, A., Andressen, C., Addicks, K., Magni, G., Ribchester, R.R., Perry, V.H., Coleman, M.P. Nat. Neurosci. (2001) [Pubmed]
  3. A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the slow Wallerian degeneration (WldS) mouse. Conforti, L., Tarlton, A., Mack, T.G., Mi, W., Buckmaster, E.A., Wagner, D., Perry, V.H., Coleman, M.P. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. The neuroprotective WldS gene regulates expression of PTTG1 and erythroid differentiation regulator 1-like gene in mice and human cells. Gillingwater, T.H., Wishart, T.M., Chen, P.E., Haley, J.E., Robertson, K., MacDonald, S.H., Middleton, S., Wawrowski, K., Shipston, M.J., Melmed, S., Wyllie, D.J., Skehel, P.A., Coleman, M.P., Ribchester, R.R. Hum. Mol. Genet. (2006) [Pubmed]
  5. Localization of the deoxyribonucleotide biosynthetic enzymes ribonucleotide reductase and thymidylate synthase in mouse L cells. Kucera, R., Paulus, H. Exp. Cell Res. (1986) [Pubmed]
  6. Human homologue of a gene mutated in the slow Wallerian degeneration (C57BL/Wld(s)) mouse. Fernando, F.S., Conforti, L., Tosi, S., Smith, A.D., Coleman, M.P. Gene (2002) [Pubmed]
  7. Stable inheritance of an 85-kb triplication in C57BL/WldS mice. Mi, W., Glass, J.D., Coleman, M.P. Mutat. Res. (2003) [Pubmed]
  8. Low nicotinamide mononucleotide adenylyltransferase activity in a tiazofurin-resistant cell line: effects on NAD metabolism and DNA repair. Boulton, S., Kyle, S., Durkacz, B.W. Br. J. Cancer (1997) [Pubmed]
  9. A rat model of slow Wallerian degeneration (WldS) with improved preservation of neuromuscular synapses. Adalbert, R., Gillingwater, T.H., Haley, J.E., Bridge, K., Beirowski, B., Berek, L., Wagner, D., Grumme, D., Thomson, D., Celik, A., Addicks, K., Ribchester, R.R., Coleman, M.P. Eur. J. Neurosci. (2005) [Pubmed]
  10. Age-dependent synapse withdrawal at axotomised neuromuscular junctions in Wld(s) mutant and Ube4b/Nmnat transgenic mice. Gillingwater, T.H., Thomson, D., Mack, T.G., Soffin, E.M., Mattison, R.J., Coleman, M.P., Ribchester, R.R. J. Physiol. (Lond.) (2002) [Pubmed]
  11. The cellular distribution of the Wld s chimeric protein and its constituent proteins in the CNS. Fang, C., Bernardes-Silva, M., Coleman, M.P., Perry, V.H. Neuroscience (2005) [Pubmed]
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