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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Term Birth

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Disease relevance of Term Birth


Psychiatry related information on Term Birth


High impact information on Term Birth

  • Uterine PGF2 alpha values were increased only at the time of term birth, but PGE2 was elevated during both preterm and term labor [7].
  • 2. Implantation of a progesterone-releasing pellet in intact pregnant dams on GD 16 delayed birth at term until GD 20.9 +/- 0.4 and inhibited the GD 18 increase in placental PGF(2alpha) levels in conjunction with a delayed fall in plasma progesterone that reached its lowest level 1 day after term birth [8].
  • At progesterone-delayed term birth on GD 19.3, even though tissue PGF(2alpha) concentrations were at the same high levels observed at normal term birth, CX-43 and FP mRNA levels were lower than those at normal term birth, thereby possibly contributing to the delay of birth [8].
  • In conclusion, the trophic effect of enteral vs. parenteral nutrition on the GI tract is also present after preterm birth, but the postnatal maturation of many GI functions is modified, compared with term birth [9].
  • RESULTS: Term birth measurements confirm that the growth deficiency of Bloom syndrome has prenatal onset [10].

Anatomical context of Term Birth


Associations of Term Birth with chemical compounds

  • Tissue was also collected from control (C) lambs soon after term birth (TEA) and at 6 weeks post-TEA [14].
  • At term birth, racial and gender differences have been observed with white compared to black, and female compared to male, infants having higher cholesterol concentrations [15].

Gene context of Term Birth

  • Increased expression of PGHS in these tissues may therefore be involved in the events leading to term birth [16].
  • In fetal rabbit lung, the activity of methionine adenosyltransferase decreased 2.5-fold during the last third of pregnancy, whereas a 2-fold increase occurred during the first 48 hr after term birth [17].
  • Moreover, the expression of prolyl hydroxylase domain-containing proteins 2 and 3 (PHD-2 and -3), which degrade HIFs, was increased following term birth [18].
  • Thus MAP2 immunohistochemistry demonstrates that dendrogenesis in human brainstem auditory nuclei begins 16 weeks prior to term birth but does not reach the stage of mature dendritic morphology until several months into the postnatal period [19].
  • A transition from fetal to adult protein C form was found beginning 6 d before term birth, with a doubling time of 24 h [20].

Analytical, diagnostic and therapeutic context of Term Birth

  • Also for term birth infants, IVF/ICSI twins were more likely to be hospitalized than IVF/ICSI singletons: adjusted OR 1.37 (1.22, 1.51) [21].


  1. Preterm birth affects the intestinal response to parenteral and enteral nutrition in newborn pigs. Sangild, P.T., Petersen, Y.M., Schmidt, M., Elnif, J., Petersen, T.K., Buddington, R.K., Greisen, G., Michaelsen, K.F., Burrin, D.G. J. Nutr. (2002) [Pubmed]
  2. Pregnancy in past or present lupus nephritis: a study of 32 pregnancies from a single centre. Huong, D.L., Wechsler, B., Vauthier-Brouzes, D., Beaufils, H., Lefebvre, G., Piette, J.C. Ann. Rheum. Dis. (2001) [Pubmed]
  3. Optimization of fetal weight estimates using MRI: comparison of acquisitions. Hassibi, S., Farhataziz, N., Zaretsky, M., McIntire, D., Twickler, D.M. AJR. American journal of roentgenology. (2004) [Pubmed]
  4. Chemical pregnancies: immunologic and ultrasonographic studies. Coulam, C.B., Roussev, R. Am. J. Reprod. Immunol. (2002) [Pubmed]
  5. Heat shock proteins and heat shock protein-antibody complexes in placental tissues. Ziegert, M., Witkin, S.S., Sziller, I., Alexander, H., Brylla, E., Härtig, W. Infectious diseases in obstetrics and gynecology. (1999) [Pubmed]
  6. Posttraumatic stress disorder after pre-eclampsia: an exploratory study. Engelhard, I.M., van Rij, M., Boullart, I., Ekhart, T.H., Spaanderman, M.E., van den Hout, M.A., Peeters, L.L. General hospital psychiatry. (2002) [Pubmed]
  7. Expression of myometrial activation and stimulation genes in a mouse model of preterm labor: myometrial activation, stimulation, and preterm labor. Cook, J.L., Zaragoza, D.B., Sung, D.H., Olson, D.M. Endocrinology (2000) [Pubmed]
  8. Mouse placental prostaglandins are associated with uterine activation and the timing of birth. Cook, J.L., Shallow, M.C., Zaragoza, D.B., Anderson, K.I., Olson, D.M. Biol. Reprod. (2003) [Pubmed]
  9. Preterm birth affects the intestinal response to parenteral and enteral nutrition in newborn pigs. Sangild, P.T., Petersen, Y.M., Schmidt, M., Elnif, J., Petersen, T.K., Buddington, R.K., Greisen, G., Michaelsen, K.F., Burrin, D.G. J. Nutr. (2002) [Pubmed]
  10. Growth deficiency and malnutrition in Bloom syndrome. Keller, C., Keller, K.R., Shew, S.B., Plon, S.E. J. Pediatr. (1999) [Pubmed]
  11. Hormone synthesis and storage in the thyroid of human preterm and term newborns: effect of thyroxine treatment. van den Hove, M.F., Beckers, C., Devlieger, H., de Zegher, F., De Nayer, P. Biochimie (1999) [Pubmed]
  12. Changes in Matrix Metalloproteinase (MMP)-2 and MMP-9 in the Fetal Amnion and Chorion During Gestation and at Term and Preterm Labor. Yonemoto, H., Young, C.B., Ross, J.T., Guilbert, L.L., Fairclough, R.J., Olson, D.M. Placenta (2006) [Pubmed]
  13. Duchenne and Becker muscular dystrophies: genetics, prenatal diagnosis, and future prospects. Bieber, F.R., Hoffman, E.P. Clinics in perinatology. (1990) [Pubmed]
  14. Pulmonary function and structure following mild preterm birth in lambs. Cock, M., Hanna, M., Sozo, F., Wallace, M., Yawno, T., Suzuki, K., Maritz, G., Hooper, S., Harding, R. Pediatr. Pulmonol. (2005) [Pubmed]
  15. Plasma cholesterol and lipoprotein levels during fetal development and infancy. Carlson, S.E. Ann. N. Y. Acad. Sci. (1991) [Pubmed]
  16. Prostaglandin endoperoxide H synthase mRNA expression in the fetal membranes correlates with fetal fibronectin concentration in the cervico-vaginal fluids at term: evidence of enzyme induction before the onset of labour. Mijovic, J.E., Demianczuk, N., Olson, D.M., Zakar, T. BJOG : an international journal of obstetrics and gynaecology. (2000) [Pubmed]
  17. Methionine adenosyltransferase and transmethylation in fetal and neonatal lung of the human, monkey, and rabbit. Sternowsky, H.J., Räihä, N.C., Gaull, G. Pediatr. Res. (1976) [Pubmed]
  18. Effect of preterm birth on hypoxia-inducible factors and vascular endothelial growth factor in primate lungs. Asikainen, T.M., Ahmad, A., Schneider, B.K., White, C.W. Pediatr. Pulmonol. (2005) [Pubmed]
  19. MAP2 expression in developing dendrites of human brainstem auditory neurons. Moore, J.K., Guan, Y.L., Shi, S.R. J. Chem. Neuroanat. (1998) [Pubmed]
  20. Identification of a unique form of protein C in the ovine fetus: developmentally linked transition to the adult form. Manco-Johnson, M.J., Spedale, S., Peters, M., Townsend, S.F., Jacobson, L.J., Christian, J., Krugman, S.D., Hay, W.W., Sparks, J.W. Pediatr. Res. (1995) [Pubmed]
  21. Hospital care utilization of IVF/ICSI twins followed until 2-7 years of age: a controlled Danish national cohort study. Pinborg, A., Loft, A., Rasmussen, S., Nyboe Andersen, A. Hum. Reprod. (2004) [Pubmed]
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