The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SRPK2  -  SRSF protein kinase 2

Homo sapiens

Synonyms: SFRS protein kinase 2, SFRSK2, SR-protein-specific kinase 2, Serine/arginine-rich protein-specific kinase 2
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SRPK2

  • However, increasing SRPK2 function up-regulates HIV expression [1].
  • Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein [2].

High impact information on SRPK2

  • Incubation of recombinant caspases with in vitro-translated SRPKs demonstrates that SRPK1 and SRPK2 are in vitro substrates for caspases-8 and -9, respectively [3].
  • Random peptide selection for preferred phosphorylation sites revealed a stringent preference of SRPK2 for SR dipeptides, and the consensus derived may be used to predict potential phosphorylation sites in candidate arginine and serine-rich (RS) domain-containing proteins [4].
  • Interestingly, SRPK2 also contains a proline-rich sequence at its NH2 terminus, and a recent study showed that this NH2-terminal sequence has the capacity to interact with a WW domain protein in vitro [4].
  • We report here the cloning and characterization of SRPK2, which is highly related to SRPK1 in sequence, kinase activity, and substrate specificity [4].
  • SRPK1 is highly expressed in pancreas, whereas SRPK2 is highly expressed in brain, although both are coexpressed in other human tissues and in many experimental cell lines [4].

Biological context of SRPK2


Anatomical context of SRPK2


Associations of SRPK2 with chemical compounds


Enzymatic interactions of SRPK2


Other interactions of SRPK2

  • Expression of an SRPK2 kinase-inactive mutant caused accumulation of SF2/ASF in the cytoplasm [10].


  1. Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Fukuhara, T., Hosoya, T., Shimizu, S., Sumi, K., Oshiro, T., Yoshinaka, Y., Suzuki, M., Yamamoto, N., Herzenberg, L.A., Herzenberg, L.A., Hagiwara, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein. Daub, H., Blencke, S., Habenberger, P., Kurtenbach, A., Dennenmoser, J., Wissing, J., Ullrich, A., Cotten, M. J. Virol. (2002) [Pubmed]
  3. Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway. Kamachi, M., Le, T.M., Kim, S.J., Geiger, M.E., Anderson, P., Utz, P.J. J. Exp. Med. (2002) [Pubmed]
  4. SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. Wang, H.Y., Lin, W., Dyck, J.A., Yeakley, J.M., Songyang, Z., Cantley, L.C., Fu, X.D. J. Cell Biol. (1998) [Pubmed]
  5. Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes. Wang, H.Y., Arden, K.C., Bermingham, J.R., Viars, C.S., Lin, W., Boyer, A.D., Fu, X.D. Genomics (1999) [Pubmed]
  6. Regulated cellular partitioning of SR protein-specific kinases in mammalian cells. Ding, J.H., Zhong, X.Y., Hagopian, J.C., Cruz, M.M., Ghosh, G., Feramisco, J., Adams, J.A., Fu, X.D. Mol. Biol. Cell (2006) [Pubmed]
  7. Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22. Curtiss, N.P., Bonifas, J.M., Lauchle, J.O., Balkman, J.D., Kratz, C.P., Emerling, B.M., Green, E.D., Le Beau, M.M., Shannon, K.M. Genomics (2005) [Pubmed]
  8. Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein. Zheng, Y., Fu, X.D., Ou, J.H. Virology (2005) [Pubmed]
  9. Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons. Jang, S.W., Liu, X., Fu, H., Rees, H., Yepes, M., Levey, A., Ye, K. J. Biol. Chem. (2009) [Pubmed]
  10. The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). Koizumi, J., Okamoto, Y., Onogi, H., Mayeda, A., Krainer, A.R., Hagiwara, M. J. Biol. Chem. (1999) [Pubmed]
WikiGenes - Universities