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Gene Review

Cd209b  -  CD209b antigen

Mus musculus

Synonyms: 1810030I22Rik, CD209 antigen-like protein B, DC-SIGN-related protein 1, DC-SIGNR1, OtB7, ...
 
 
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Disease relevance of Cd209b

  • Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection [1].
  • To better understand the mechanism by which DC-SIGN and DC-SIGNR selectively bind HIV-1 gp120, we constructed a series of deletion mutations in the repeat regions of both receptors [2].
 

High impact information on Cd209b

  • Moreover, mSIGNR1 is also expressed by medullary and subcapsular macrophages in lymph nodes and by marginal zone macrophages (MZMs) in the spleen [3].
  • We demonstrate here that mSIGNR1 functions in vivo as a pathogen recognition receptor on MZMs that capture blood-borne antigens, which are rapidly internalized and targeted to lysosomes for processing [3].
  • The finding that neither SIGNR1 nor SIGNR5 binds with high affinity to specific ligands in a large panel of mammalian glycans is consistent with the suggestion that these receptors bind surface polysaccharides on bacterial and fungal pathogens in a manner analogous to serum mannose-binding protein [4].
  • In addition to five SIGNR proteins previously described, a pseudogene, encoding a hypothetical SIGNR6, and a further two expressed proteins, SIGNR7 and SIGNR8, have been identified [4].
  • However, in the nonprofessional phagocytes (NIH3T3), SIGNR1 was found to be poorly phagocytic, suggesting that other receptors such as betaGR may play a more dominant role in particle internalization on professional phagocytes [5].
 

Biological context of Cd209b

  • However, SIGNR1 is not expressed by alveolar macrophages, suggesting that another mechanism than a decrease in phagocytosis is responsible for this difference [1].
  • We demonstrate that marginal zone macrophages from SIGNR1-deficient mice in contrast to wild-type mice are not able to capture pneumococci from blood, suggesting that SIGNR1 on marginal zone macrophages captures S. pneumoniae for antigen presentation to and activation of marginal zone B cells, resulting in an anti-phosphorylcholine IgM response [1].
 

Anatomical context of Cd209b

 

Associations of Cd209b with chemical compounds

  • In this study, we have studied the mannose-binding potential of murine Mphi and identified the dendritic cell-specific ICAM-3-grabbing nonintegrin homolog, SIGN-related 1 (SIGNR1), as a major MR on murine resident peritoneal Mphi [5].
  • In addition, resident peritoneal CD11b+ cells expressing SIGNR1 bound zymosan at 4 degrees C in concert with a laminarin-sensitive receptor [6].
  • Interestingly, transfectants with SIGNR1 lacking the cytoplasmic domain were capable of binding FITC-zymosan in a manner that was abolished by EDTA or mannan, but not laminarin [6].

References

  1. Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection. Koppel, E.A., Wieland, C.W., van den Berg, V.C., Litjens, M., Florquin, S., van Kooyk, Y., van der Poll, T., Geijtenbeek, T.B. Eur. J. Immunol. (2005) [Pubmed]
  2. Characterization of DC-SIGN/R interaction with human immunodeficiency virus type 1 gp120 and ICAM molecules favors the receptor's role as an antigen-capturing rather than an adhesion receptor. Snyder, G.A., Ford, J., Torabi-Parizi, P., Arthos, J.A., Schuck, P., Colonna, M., Sun, P.D. J. Virol. (2005) [Pubmed]
  3. Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo. Geijtenbeek, T.B., Groot, P.C., Nolte, M.A., van Vliet, S.J., Gangaram-Panday, S.T., van Duijnhoven, G.C., Kraal, G., van Oosterhout, A.J., van Kooyk, Y. Blood (2002) [Pubmed]
  4. Widely divergent biochemical properties of the complete set of mouse DC-SIGN-related proteins. Powlesland, A.S., Ward, E.M., Sadhu, S.K., Guo, Y., Taylor, M.E., Drickamer, K. J. Biol. Chem. (2006) [Pubmed]
  5. The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages. Taylor, P.R., Brown, G.D., Herre, J., Williams, D.L., Willment, J.A., Gordon, S. J. Immunol. (2004) [Pubmed]
  6. Functional comparison of the mouse DC-SIGN, SIGNR1, SIGNR3 and Langerin, C-type lectins. Takahara, K., Yashima, Y., Omatsu, Y., Yoshida, H., Kimura, Y., Kang, Y.S., Steinman, R.M., Park, C.G., Inaba, K. Int. Immunol. (2004) [Pubmed]
 
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