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Gene Review

TUFT1  -  tuftelin 1

Homo sapiens

Synonyms: Tuftelin
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Disease relevance of TUFT1


High impact information on TUFT1

  • Within the developing tooth organ, TIP39 and tuftelin immunolocalized to the apical pole of secretory ameloblasts (Tomes' processes) and to the newly secreted extracellular enamel matrix [3].
  • Amelogenin and tuftelin fail to interact with each other [4].
  • Detailed DNA analysis of the cloned genomic DNA revealed that the human tuftelin gene contains 13 exons and is larger than 26 kb [5].
  • Sequence analysis of the tuftelin cDNA revealed an open reading frame of 1170 bp encoding a 390 amino acid protein with a molecular mass of 44.3 kDa and an isoelectric point of 5 [5].
  • 7. The human tuftelin protein shares 89 and 88% amino acid sequence identity with the bovine and mouse tuftelin, respectively [5].

Biological context of TUFT1


Anatomical context of TUFT1

  • It describes the distribution of tuftelin in the ameloblast cell and in the extracellular enamel matrix, employing high resolution protein-A gold immunocytochemistry [1].
  • The organic matrix is highly heterogeneous, comprising proteins derived from a number of different genes, including amelogenin, enamelin, ameloblastin (amelin/sheathlin), tuftelin, dentine sialophosphoprotein, enzymes and serum proteins such as albumin [10].
  • Epithelial cells were stained with anti-cytokeratin 5 and 8 antibodies and showed the expression of tuftelin mRNA [11].

Other interactions of TUFT1

  • This paper reviews the primary structure, characteristics and possible function of tuftelin/enamelin protein [1].
  • BMP-2, SPARC and tuftelin mRNAs were detected in ECHPL and the other cells examined [12].
  • It describes the mechanisms associated with the major events in biosynthesis and degradation of the major enamel proteins (amelogenins and tuftelin/enamelins) and with the presecretory and postsecretory mechanisms leading to the heterogeneity of these extracellular matrix proteins [13].

Analytical, diagnostic and therapeutic context of TUFT1


  1. The enamelin (tuftelin) gene. Deutsch, D., Palmon, A., Dafni, L., Catalano-Sherman, J., Young, M.F., Fisher, L.W. Int. J. Dev. Biol. (1995) [Pubmed]
  2. Tuftelin mRNA is expressed in a human ameloblastoma tumor. Deutsch, D., Fermon, E., Lustmann, J., Dafni, L., Mao, Z., Leytin, V., Palmon, A. Connect. Tissue Res. (1998) [Pubmed]
  3. A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts. Paine, C.T., Paine, M.L., Luo, W., Okamoto, C.T., Lyngstadaas, S.P., Snead, M.L. J. Biol. Chem. (2000) [Pubmed]
  4. Protein interactions during assembly of the enamel organic extracellular matrix. Paine, M.L., Snead, M.L. J. Bone Miner. Res. (1997) [Pubmed]
  5. The human tuftelin gene: cloning and characterization. Mao, Z., Shay, B., Hekmati, M., Fermon, E., Taylor, A., Dafni, L., Heikinheimo, K., Lustmann, J., Fisher, L.W., Young, M.F., Deutsch, D. Gene (2001) [Pubmed]
  6. Mapping of the human tuftelin (TUFT1) gene to chromosome 1 by fluorescence in situ hybridization. Deutsch, D., Palmon, A., Young, M.F., Selig, S., Kearns, W.G., Fisher, L.W. Mamm. Genome (1994) [Pubmed]
  7. The human tuftelin gene and the expression of tuftelin in mineralizing and nonmineralizing tissues. Deutsch, D., Leiser, Y., Shay, B., Fermon, E., Taylor, A., Rosenfeld, E., Dafni, L., Charuvi, K., Cohen, Y., Haze, A., Fuks, A., Mao, Z. Connect. Tissue Res. (2002) [Pubmed]
  8. Molecular cloning and characterization of the bovine and human tuftelin genes. Bashir, M.M., Abrams, W.R., Tucker, T., Sellinger, B., Budarf, M., Emanuel, B., Rosenbloom, J. Connect. Tissue Res. (1998) [Pubmed]
  9. Protein-to-protein interactions: criteria defining the assembly of the enamel organic matrix. Paine, M.L., Krebsbach, P.H., Chen, L.S., Paine, C.T., Yamada, Y., Deutsch, D., Snead, M.L. J. Dent. Res. (1998) [Pubmed]
  10. The developing enamel matrix: nature and function. Robinson, C., Brookes, S.J., Shore, R.C., Kirkham, J. Eur. J. Oral Sci. (1998) [Pubmed]
  11. Enhancement of alkaline phosphatase synthesis in pulp cells co-cultured with epithelial cells derived from lower rabbit incisors. Shiba, H., Mouri, Y., Komatsuzawa, H., Mizuno, N., Xu, W., Noguchi, T., Nakamura, S., Sugai, M., Kato, Y., Kurihara, H. Cell Biol. Int. (2003) [Pubmed]
  12. Characterization of epithelial cells derived from periodontal ligament by gene expression patterns of bone-related and enamel proteins. Mizuno, N., Shiba, H., Mouri, Y., Xu, W., Kudoh, S., Kawaguchi, H., Kurihara, H. Cell Biol. Int. (2005) [Pubmed]
  13. Enamel matrix proteins and ameloblast biology. Deutsch, D., Catalano-Sherman, J., Dafni, L., David, S., Palmon, A. Connect. Tissue Res. (1995) [Pubmed]
  14. Tuftelin: enamel mineralization and amelogenesis imperfecta. Deutsch, D., Dafni, L., Palmon, A., Hekmati, M., Young, M.F., Fisher, L.W. Ciba Found. Symp. (1997) [Pubmed]
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