The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Hyal5  -  hyaluronoglucosaminidase 5

Mus musculus

Synonyms: 4933439A12Rik
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Hyal5

  • In this study, we purified the 55-kDa mouse protein from soluble protein extracts released from epididymal sperm by acrosome reaction and identified as a hyaluronidase, Hyal5 [1].
  • These results suggest that in the mouse, Hyal5 may function principally as a "cumulus matrix depolymerase" in the sperm penetration through the cumulus mass and in the local hyaluronan hydrolysis near or on the surface of the egg zona pellucida to enable the proximal region of sperm tail to move freely [1].
  • Hyal5 was a single-chain hyaluronidase present on the plasma and acrosomal membranes of sperm presumably as a GPI-anchored protein [1].
  • Also, three transgenic lines showed a modest downregulation or co-suppression of the RNA for Spam1 and Hyal5, present on the BAC [2].
  • Here we show that closely linked family members in the hyaluronidase gene cluster on mouse chromosome 6, Hyalp1 and Hyal5, also harbor point mutations in these Rbs, leading to nonconservative substitutions in both the encoded proteins [3].

Biological context of Hyal5


Anatomical context of Hyal5

  • We have now recombinantly expressed mouse SPAM1, HYAL5 and HYALP1 in Xenopus laevis oocytes and determined their respective expression pattern in testis [5].

Other interactions of Hyal5

  • This lack of TRD in null carriers argues for only a contributory role of Spam1 in the TRD seen in the Rb-bearing mice, and supports the involvement of Hyalp1 and/or Hyal5 in the sperm dysfunction and the resulting TRD [3].


  1. Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus mass. Kim, E., Baba, D., Kimura, M., Yamashita, M., Kashiwabara, S., Baba, T. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Murine Spam1 mRNA: involvement of AU-rich elements in the 3'UTR and antisense RNA in its tight post-transcriptional regulation in spermatids. Zhang, H., Barnoski, B.L., Sol-Church, K., Stabley, D.L., Martin-Deleon, P.A. Mol. Reprod. Dev. (2006) [Pubmed]
  3. Sperm dysfunction in the Rb(6.16)- and Rb(6.15)-bearing mice revisited: involvement of Hyalp1 and Hyal5. Zhang, H., Shertok, S., Miller, K., Taylor, L., Martin-Deleon, P.A. Mol. Reprod. Dev. (2005) [Pubmed]
  4. Spam1-associated transmission ratio distortion in mice: elucidating the mechanism. Martin-DeLeon, P.A., Zhang, H., Morales, C.R., Zhao, Y., Rulon, M., Barnoski, B.L., Chen, H., Galileo, D.S. Reprod. Biol. Endocrinol. (2005) [Pubmed]
  5. Mouse testicular hyaluronidase-like proteins SPAM1 and HYAL5 but not HYALP1 degrade hyaluronan. Reitinger, S., Laschober, G.T., Fehrer, C., Greiderer, B., Lepperdinger, G. Biochem. J. (2007) [Pubmed]
WikiGenes - Universities