Gene Review:
SPAM1 - sperm adhesion molecule 1 (PH-20...
Homo sapiens
Synonyms:
HEL-S-96n, HYA1, HYAL1, HYAL3, HYAL5, ...
- Transcription of the human and rodent SPAM1 / PH-20 genes initiates within an ancient endogenous retrovirus. Dunn, C.A., Mager, D.L. BMC Genomics (2005)
- Hyaluronidase expression induces prostate tumor metastasis in an orthotopic mouse model. Kovar, J.L., Johnson, M.A., Volcheck, W.M., Chen, J., Simpson, M.A. Am. J. Pathol. (2006)
- Quantification of F-18 FDG PET images in temporal lobe epilepsy patients using probabilistic brain atlas. Kang, K.W., Lee, D.S., Cho, J.H., Lee, J.S., Yeo, J.S., Lee, S.K., Chung, J.K., Lee, M.C. Neuroimage (2001)
- High-fat foods and the risk of lung cancer. Goodman, M.T., Hankin, J.H., Wilkens, L.R., Kolonel, L.N. Epidemiology (Cambridge, Mass.) (1992)
- Expression patterns of hyaluronan, hyaluronan synthases and hyaluronidases indicate a role for hyaluronan in the progression of endometrial cancer. Paiva, P., Van Damme, M.P., Tellbach, M., Jones, R.L., Jobling, T., Salamonsen, L.A. Gynecol. Oncol. (2005)
- Fully effective contraception in male and female guinea pigs immunized with the sperm protein PH-20. Primakoff, P., Lathrop, W., Woolman, L., Cowan, A., Myles, D. Nature (1988)
- A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg. Lin, Y., Mahan, K., Lathrop, W.F., Myles, D.G., Primakoff, P. J. Cell Biol. (1994)
- cDNA cloning reveals the molecular structure of a sperm surface protein, PH-20, involved in sperm-egg adhesion and the wide distribution of its gene among mammals. Lathrop, W.F., Carmichael, E.P., Myles, D.G., Primakoff, P. J. Cell Biol. (1990)
- Molecular cloning of the human and monkey sperm surface protein PH-20. Lin, Y., Kimmel, L.H., Myles, D.G., Primakoff, P. Proc. Natl. Acad. Sci. U.S.A. (1993)
- The modulation of granulomatous tissue and tumour angiogenesis by diclofenac in combination with hyaluronan (HYAL EX-0001). Freemantle, C., Alam, C.A., Brown, J.R., Seed, M.P., Willoughby, D.A. International journal of tissue reactions. (1995)
- Expression analysis, genomic structure, and mapping to 7q31 of the human sperm adhesion molecule gene SPAM1. Jones, M.H., Davey, P.M., Aplin, H., Affara, N.A. Genomics (1995)
- SPAM1 (PH-20) protein and mRNA expression in the epididymides of humans and macaques: utilizing laser microdissection/RT-PCR. Evans, E.A., Zhang, H., Martin-DeLeon, P.A. Reprod. Biol. Endocrinol. (2003)
- Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31. Csóka, A.B., Scherer, S.W., Stern, R. Genomics (1999)
- Epididymal SPAM1 and its impact on sperm function. Martin-Deleon, P.A. Mol. Cell. Endocrinol. (2006)
- Cytoplasmic localization during testicular biogenesis of the murine mRNA for Spam1 (PH-20), a protein involved in acrosomal exocytosis. Morales, C.R., Badran, H., El-Alfy, M., Men, H., Zhang, H., Martin-DeLeon, P.A. Mol. Reprod. Dev. (2004)
- Expression and secretion of rat SPAM1(2B1 or PH-20) in the epididymis: role of testicular lumicrine factors. Zhang, H., Jones, R., Martin-DeLeon, P.A. Matrix Biol. (2004)
- Spam1 (PH-20) expression in the extratesticular duct and accessory organs of the mouse: a possible role in sperm fluid reabsorption. Zhang, H., Morales, C.R., Badran, H., El-Alfy, M., Martin-DeLeon, P.A. Biol. Reprod. (2004)
- Vaccine for contraception targeting sperm. Naz, R.K. Immunol. Rev. (1999)
- Sequence identity and antigenic cross-reactivity of white face hornet venom allergen, also a hyaluronidase, with other proteins. Lu, G., Kochoumian, L., King, T.P. J. Biol. Chem. (1995)
- Two-dimensional gel electrophoretic analysis of vectorially labeled surface proteins of human spermatozoa. Naaby-Hansen, S., Flickinger, C.J., Herr, J.C. Biol. Reprod. (1997)
- Hyaluronidases and CD44 undergo differential modulation during chondrogenesis. Nicoll, S.B., Barak, O., Csóka, A.B., Bhatnagar, R.S., Stern, R. Biochem. Biophys. Res. Commun. (2002)
- Sperm adhesion molecules: structure and function. Jansen, S., Ekhlasi-Hundrieser, M., Töpfer-Petersen, E. Cells Tissues Organs (Print) (2001)
- Purification and microsequencing of hyaluronidase isozymes from human urine. Csóka, A.B., Frost, G.I., Wong, T., Stern, R., Csóka, T.B. FEBS Lett. (1997)
- Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase. Strobl, B., Wechselberger, C., Beier, D.R., Lepperdinger, G. Genomics (1998)
- PH20: a novel tumor marker for laryngeal cancer. Godin, D.A., Fitzpatrick, P.C., Scandurro, A.B., Belafsky, P.C., Woodworth, B.A., Amedee, R.G., Beech, D.J., Beckman, B.S. Arch. Otolaryngol. Head Neck Surg. (2000)
- Hyalp1 in murine sperm function: evidence for unique and overlapping functions with other reproductive hyaluronidases. Miller, K.A., Shao, M., Martin-Deleon, P.A. J. Androl. (2007)
- Expression of tumor markers hyaluronic acid and hyaluronidase (HYAL1) in head and neck tumors. Franzmann, E.J., Schroeder, G.L., Goodwin, W.J., Weed, D.T., Fisher, P., Lokeshwar, V.B. Int. J. Cancer (2003)