Disease relevance of WNT6

• WNT10A and WNT6 were strongly coexpressed in SW480 (colorectal cancer) [1].
• In addition to SW480, WNT10A was strongly expressed in HL-60 (promyelocytic leukemia) and Raji (Burkitt's lymphoma), and WNT6 in HeLa S3 (cervical cancer) [1].
• The 2.0-kb WNT6 mRNA was expressed in gastric cancer cell lines MKN28 and MKN74 [2].
• Effects of inflammatory cytokines and Helicobacter pylori (H. pylori) on expression of WNT10A and WNT6 were next investigated [2].

High impact information on WNT6

• We show that Wnt1 and Wnt3a signaling from the neural tube inhibit Wnt6 expression in the medial surface ectoderm via dermomyotomal Wnt11 [3].
• We demonstrate that Wnt11 is an epithelialization factor acting on the medial dermomyotome, and present a model suggesting Wnt11 and Wnt6 as factors maintaining the epithelial nature of the dorsomedial and ventrolateral lips of the dermomyotome, respectively, during dermomyotomal growth [3].
• At the level of the segmental plate and the epithelial somites, Wnt6 is expressed in the entire ectoderm overlying the neural tube, the paraxial mesoderm and the lateral plate mesoderm [3].
• Ectodermal Wnt6 plays an important role during development of the somites and the lateral plate mesoderm [3].
• Wnt4 and Wnt6 mRNA expressions were increased compared to controls, while expression of Wnt5a was similar to the control and that of Wnt7a mRNA was decreased [4].

Biological context of WNT6

• WNT6 and WNT10A genes at human chromosome 2q35 are clustered in tail-to-head manner with an interval of <7 kb [5].
• Promoter region was conserved between rat Wnt6 and human WNT6 genes [5].
• Here, we identified and characterized rat Wnt6 and Wnt10a genes by using bioinformatics [5].
• Wnt6 and Wnt10a genes were clustered in tail-to-head manner with an interval of about 7 kb within AC127107.3 and AC132020.3 genome sequences [5].
• Interferon gamma (IFNgamma) failed to induce up-regulation of WNT10A and WNT6 [2].

Anatomical context of WNT6

• Here, we show that, in avians, Wnt6 is localized in ectoderm and in vivo inhibition of Wnt signaling perturbs neural crest formation [6].

Regulatory relationships of WNT6

• The 2.0-kb WNT6 mRNA was coexpressed with WNT10A in placenta and adult spleen [1].

Other interactions of WNT6

• Rat Wnt6 and human WNT6 showed 97.8% total-amino-acid identity, while rat Wnt10a and human WNT10A showed 95.4% total-amino-acid identity [5].
• Finally, we show that Wnt6 can mimic the effect of the dorsal ectoderm to maintain Pax3 and Pax7 expression [7].

Analytical, diagnostic and therapeutic context of WNT6

• Partial cloning and assignment of WNT6 to human chromosome band 2q35 by in situ hybridization [8].

References