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Gene Review

WNT6  -  wingless-type MMTV integration site family...

Homo sapiens

Synonyms: Protein Wnt-6
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Disease relevance of WNT6


High impact information on WNT6

  • We show that Wnt1 and Wnt3a signaling from the neural tube inhibit Wnt6 expression in the medial surface ectoderm via dermomyotomal Wnt11 [3].
  • We demonstrate that Wnt11 is an epithelialization factor acting on the medial dermomyotome, and present a model suggesting Wnt11 and Wnt6 as factors maintaining the epithelial nature of the dorsomedial and ventrolateral lips of the dermomyotome, respectively, during dermomyotomal growth [3].
  • At the level of the segmental plate and the epithelial somites, Wnt6 is expressed in the entire ectoderm overlying the neural tube, the paraxial mesoderm and the lateral plate mesoderm [3].
  • Ectodermal Wnt6 plays an important role during development of the somites and the lateral plate mesoderm [3].
  • Wnt4 and Wnt6 mRNA expressions were increased compared to controls, while expression of Wnt5a was similar to the control and that of Wnt7a mRNA was decreased [4].

Biological context of WNT6


Anatomical context of WNT6

  • Here, we show that, in avians, Wnt6 is localized in ectoderm and in vivo inhibition of Wnt signaling perturbs neural crest formation [6].

Regulatory relationships of WNT6

  • The 2.0-kb WNT6 mRNA was coexpressed with WNT10A in placenta and adult spleen [1].

Other interactions of WNT6

  • Rat Wnt6 and human WNT6 showed 97.8% total-amino-acid identity, while rat Wnt10a and human WNT10A showed 95.4% total-amino-acid identity [5].
  • Finally, we show that Wnt6 can mimic the effect of the dorsal ectoderm to maintain Pax3 and Pax7 expression [7].

Analytical, diagnostic and therapeutic context of WNT6


  1. WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells. Kirikoshi, H., Sekihara, H., Katoh, M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  2. Up-regulation of WNT10A by tumor necrosis factor alpha and Helicobacter pylori in gastric cancer. Kirikoshi, H., Sekihara, H., Katoh, M. Int. J. Oncol. (2001) [Pubmed]
  3. Regulation of ectodermal Wnt6 expression by the neural tube is transduced by dermomyotomal Wnt11: a mechanism of dermomyotomal lip sustainment. Geetha-Loganathan, P., Nimmagadda, S., Huang, R., Christ, B., Scaal, M. Development (2006) [Pubmed]
  4. Effects of sulfated hyaluronan on keratinocyte differentiation and Wnt and Notch gene expression. Nagira, T., Nagahata-Ishiguro, M., Tsuchiya, T. Biomaterials (2007) [Pubmed]
  5. Identification and characterization of rat Wnt6 and Wnt10a genes in silico. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
  6. Ectodermal Wnt function as a neural crest inducer. García-Castro, M.I., Marcelle, C., Bronner-Fraser, M. Science (2002) [Pubmed]
  7. Pax3 and Pax7 expression and regulation in the avian embryo. Otto, A., Schmidt, C., Patel, K. Anat. Embryol. (2006) [Pubmed]
  8. Partial cloning and assignment of WNT6 to human chromosome band 2q35 by in situ hybridization. Rankin, J., Strachan, T., Lako, M., Lindsay, S. Cytogenet. Cell Genet. (1999) [Pubmed]
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