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Gene Review

Wnt6  -  wingless-type MMTV integration site family...

Mus musculus

Synonyms: AA409270, Protein Wnt-6, Wnt-6
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Disease relevance of Wnt6

  • Our results indicate that several of the Wnt ligands, especially Wnt1 and Wnt6, are strongly expressed in both normal and malignant breast tissue and that Wnt7b is down-regulated in breast cancer, compared to normal breast epithelium [1].

High impact information on Wnt6

  • In contrast, Wnt-6 and two other family members which are normally expressed in C57MG cells, Wnt-4 and Wnt-5A, failed to induce transformation [2].
  • We show that Wnt6 in the ectoderm overlaying the somites, but not Wnt1 in the neighbouring neural tube, is the most likely candidate molecule responsible for the maintenance of the epithelial structure of the dorsal compartment of the somite: the dermomyotome [3].
  • Our results are also the first report of biological effects of Wnt-6 and Wnt-7b [4].
  • Furthermore, injection of Wnt6-producing cells following the isolation of the neural tube/notochord from the segmental plate was able to rescue somite formation at both the structural (epithelialisation) and molecular level, as determined by the expression of marker genes like Paraxis or Pax-3 [5].
  • More importantly, we show that Wnt6-producing cells are able to rescue somite formation after ectoderm ablation [5].

Anatomical context of Wnt6

  • Wnt5b and Wnt6 exhibit restricted expression in the epithelium of the esophagus [6].
  • We show here that a mammary line exists in the mouse embryo at embryonic day (E) 11.25 as a concise line of Wnt10b expression and a broader band of Wnt6 expression in the surface ectoderm, between the subaxillary and suprainguinal region of each flank [7].
  • We propose a model in which the localisation of Wnt6 and its antagonists regulates the process of epithelialisation in the paraxial mesoderm [5].
  • In contrast to previous reports where no effect of Wnt genes on fibroblasts was seen, we found that the expression of Wnt-1, Wnt-6 and Wnt-7b altered the appearance of the cells when maintained at confluence [4].
  • Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro [8].

Other interactions of Wnt6

  • Wnt-6 and Wnt-7a produced weak morphological changes [9].
  • The analysis of the effects of eight signaling molecules in the TGFbeta, FGF, Hh, Wnt, and EGF families in tooth explant cultures revealed that the expression of edar was induced by activinbetaA, whereas Wnt6 induced ectodysplasin expression [10].
  • Cells expressing Wnt-6 did not induce Fgf-10 expression [11].


  1. Expression of Wnt genes and frizzled 1 and 2 receptors in normal breast epithelium and infiltrating breast carcinoma. Milovanovic, T., Planutis, K., Nguyen, A., Marsh, J.L., Lin, F., Hope, C., Holcombe, R.F. Int. J. Oncol. (2004) [Pubmed]
  2. Differential transformation of mammary epithelial cells by Wnt genes. Wong, G.T., Gavin, B.J., McMahon, A.P. Mol. Cell. Biol. (1994) [Pubmed]
  3. beta-Catenin-dependent Wnt signalling controls the epithelial organisation of somites through the activation of paraxis. Linker, C., Lesbros, C., Gros, J., Burrus, L.W., Rawls, A., Marcelle, C. Development (2005) [Pubmed]
  4. Alterations of the growth characteristics of the fibroblast cell line C3H 10T1/2 by members of the Wnt gene family. Bradbury, J.M., Niemeyer, C.C., Dale, T.C., Edwards, P.A. Oncogene (1994) [Pubmed]
  5. Wnt 6 regulates the epithelialisation process of the segmental plate mesoderm leading to somite formation. Schmidt, C., Stoeckelhuber, M., McKinnell, I., Putz, R., Christ, B., Patel, K. Dev. Biol. (2004) [Pubmed]
  6. Expression patterns of Wnt genes in mouse gut development. Lickert, H., Kispert, A., Kutsch, S., Kemler, R. Mech. Dev. (2001) [Pubmed]
  7. Identification of the mammary line in mouse by Wnt10b expression. Veltmaat, J.M., Van Veelen, W., Thiery, J.P., Bellusci, S. Dev. Dyn. (2004) [Pubmed]
  8. Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro. Itäranta, P., Lin, Y., Peräsaari, J., Roël, G., Destrée, O., Vainio, S. Genesis (2002) [Pubmed]
  9. Transformation by Wnt family proteins correlates with regulation of beta-catenin. Shimizu, H., Julius, M.A., Giarré, M., Zheng, Z., Brown, A.M., Kitajewski, J. Cell Growth Differ. (1997) [Pubmed]
  10. TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis. Laurikkala, J., Mikkola, M., Mustonen, T., Aberg, T., Koppinen, P., Pispa, J., Nieminen, P., Galceran, J., Grosschedl, R., Thesleff, I. Dev. Biol. (2001) [Pubmed]
  11. Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesis. Kettunen, P., Laurikkala, J., Itäranta, P., Vainio, S., Itoh, N., Thesleff, I. Dev. Dyn. (2000) [Pubmed]
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