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Gene Review

WNT3  -  wingless-type MMTV integration site family...

Homo sapiens

Synonyms: INT4, MGC131950, MGC138321, MGC138323, Proto-oncogene Int-4 homolog, ...
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Disease relevance of WNT3


High impact information on WNT3

  • Wnt3-/- mice develop a normal egg cylinder but do not form a primitive streak, mesoderm or node [5].
  • We identified a homozygous nonsense mutation (Q83X) in the WNT3 gene in affected fetuses of the family [6].
  • Immunoprecipitation studies demonstrated physical interactions between human Ror2 and mammalian Wnt1 and Wnt3 [7].
  • These data, together with the CLP lip phenotype in WNT3(-/-) humans and Wnt9b(-/-) mutant mice, indicate that Wnt3 and Wnt9b signal through the canonical Wnt signaling pathway to regulate midfacial development and lip fusion [8].
  • Immunohistochemistry disclosed that WNT3 expression and nuclear localization of beta-catenin were predominant in carcinoma cells at the invasive front [9].

Biological context of WNT3


Anatomical context of WNT3


Other interactions of WNT3


Analytical, diagnostic and therapeutic context of WNT3


  1. Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45. Katoh, M. Int. J. Oncol. (2002) [Pubmed]
  2. Molecular cloning and characterization of human WNT3. Katoh, M. Int. J. Oncol. (2001) [Pubmed]
  3. Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma. Bui, T.D., Zhang, L., Rees, M.C., Bicknell, R., Harris, A.L. Br. J. Cancer (1997) [Pubmed]
  4. NRAMP1 genetic polymorphisms as a risk factor of tuberculous pleurisy. Kim, J.H., Lee, S.Y., Lee, S.H., Sin, C., Shim, J.J., In, K.H., Yoo, S.H., Kang, K.H. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. (2003) [Pubmed]
  5. Requirement for Wnt3 in vertebrate axis formation. Liu, P., Wakamiya, M., Shea, M.J., Albrecht, U., Behringer, R.R., Bradley, A. Nat. Genet. (1999) [Pubmed]
  6. Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. Niemann, S., Zhao, C., Pascu, F., Stahl, U., Aulepp, U., Niswander, L., Weber, J.L., Müller, U. Am. J. Hum. Genet. (2004) [Pubmed]
  7. The orphan receptor tyrosine kinase Ror2 modulates canonical Wnt signaling in osteoblastic cells. Billiard, J., Way, D.S., Seestaller-Wehr, L.M., Moran, R.A., Mangine, A., Bodine, P.V. Mol. Endocrinol. (2005) [Pubmed]
  8. Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice. Lan, Y., Ryan, R.C., Zhang, Z., Bullard, S.A., Bush, J.O., Maltby, K.M., Lidral, A.C., Jiang, R. Dev. Dyn. (2006) [Pubmed]
  9. Activation of WNT family expression and signaling in squamous cell carcinomas of the oral cavity. Uraguchi, M., Morikawa, M., Shirakawa, M., Sanada, K., Imai, K. J. Dent. Res. (2004) [Pubmed]
  10. Molecular cloning and characterization of mouse Wnt14b, clustered with mouse Wnt3 in mouse chromosome 11. Kirikoshi, H., Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
  11. WNT3-WNT14B and WNT3A-WNT14 gene clusters (Review). Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
  12. The CA repeat marker D17S791 is located within 40 kb of the WNT3 gene on chromosome 17q. Chandrasekharappa, S.C., King, S.E., Freedman, M.L., Hayes, S.T., Bowcock, A.M., Collins, F.S. Genomics (1993) [Pubmed]
  13. Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells. Chiba, H., Kobune, M., Kato, J., Kawano, Y., Ito, Y., Nakamura, K., Asakura, S., Hamada, H., Niitsu, Y. Exp. Hematol. (2004) [Pubmed]
  14. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. Kim, M., Lee, H.C., Tsedensodnom, O., Hartley, R., Lim, Y.S., Yu, E., Merle, P., Wands, J.R. J. Hepatol. (2008) [Pubmed]
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