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Gene Review

TRPM3  -  transient receptor potential cation...

Homo sapiens

Synonyms: GON-2, KIAA1616, LTRPC3, LTrpC-3, LTrpC3, ...
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High impact information on TRPM3

  • Alternative splicing switches the divalent cation selectivity of TRPM3 channels [1].
  • From its function and expression in human kidney, we propose a role of TRPM3 in renal Ca2+ homeostasis [2].
  • Depletion of intracellular Ca2+ stores by lowering extracellular Ca2+ concentration and treatment with the Ca2+-ATPase inhibitor thapsigargin or the muscarinic receptor agonist carbachol further augmented hTRPM3-mediated Ca2+ entry [3].
  • The nonselective Ca2+ channel blocker, lanthanide gadolinium (Gd3+), partially inhibited hTRPM3-mediated Ca2+ entry [3].
  • In situ hybridization in human kidney demonstrated that hTRPM3 mRNA expression is predominantly found in the collecting tubular epithelium [3].

Biological context of TRPM3


Anatomical context of TRPM3


Associations of TRPM3 with chemical compounds

  • Although sphingosine-1-phosphate and ceramides had no effect, two structural analogs of sphingosine, dihydro-D-erythro-sphingosine and N,N-dimethyl-D-erythro-sphingosine, also activated TRPM3 [7].
  • Activation of the melastatin-related cation channel TRPM3 [corrected] by D-erythro-sphingosine [7].
  • Heterologously expressed TRPM3 channels are constitutively active, have an outwardly rectifying current-voltage relationship and are inhibited by intracellular Mg(2+) ions [8].

Other interactions of TRPM3

  • TRPM3, a member of the melastatin-like transient receptor potential channel subfamily (TRPM), is predominantly expressed in human kidney and brain [7].
  • 6 2-APB also blocks TRPC6 and TRPM3 expressed in HEK-293 cells, but not TRPM2 [9].
  • TRPM2, TRPM3 and TRPM8 mediate a direct influx of Ca(2+) in response to specific stimuli [10].

Analytical, diagnostic and therapeutic context of TRPM3


  1. Alternative splicing switches the divalent cation selectivity of TRPM3 channels. Oberwinkler, J., Lis, A., Giehl, K.M., Flockerzi, V., Philipp, S.E. J. Biol. Chem. (2005) [Pubmed]
  2. Molecular and functional characterization of the melastatin-related cation channel TRPM3. Grimm, C., Kraft, R., Sauerbruch, S., Schultz, G., Harteneck, C. J. Biol. Chem. (2003) [Pubmed]
  3. Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3). Lee, N., Chen, J., Sun, L., Wu, S., Gray, K.R., Rich, A., Huang, M., Lin, J.H., Feder, J.N., Janovitz, E.B., Levesque, P.C., Blanar, M.A. J. Biol. Chem. (2003) [Pubmed]
  4. Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides. Deo, M., Yu, J.Y., Chung, K.H., Tippens, M., Turner, D.L. Dev. Dyn. (2006) [Pubmed]
  5. Characterization of Ca2+ influx induced by dimethylphytosphingosine and lysophosphatidylcholine in U937 monocytes. Lee, Y.K., Im, Y.J., Kim, Y.L., Im, D.S. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  6. Effects of macrophage colony-stimulating factor on folliculogenesis in gonadotrophin-primed immature rats. Nishimura, K., Tanaka, N., Ohshige, A., Fukumatsu, Y., Matsuura, K., Okamura, H. J. Reprod. Fertil. (1995) [Pubmed]
  7. Activation of the melastatin-related cation channel TRPM3 [corrected] by D-erythro-sphingosine. Grimm, C., Kraft, R., Schultz, G., Harteneck, C. Mol. Pharmacol. (2005) [Pubmed]
  8. TRPM3, a biophysical enigma? Oberwinkler, J. Biochem. Soc. Trans. (2007) [Pubmed]
  9. Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect. Xu, S.Z., Zeng, F., Boulay, G., Grimm, C., Harteneck, C., Beech, D.J. Br. J. Pharmacol. (2005) [Pubmed]
  10. The mammalian melastatin-related transient receptor potential cation channels: an overview. Kraft, R., Harteneck, C. Pflugers Arch. (2005) [Pubmed]
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