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Gene Review

TRPM1  -  transient receptor potential cation...

Homo sapiens

Synonyms: CSNB1C, LTRPC1, LTrpC1, Long transient receptor potential channel 1, MLSN, ...
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Disease relevance of TRPM1


Psychiatry related information on TRPM1

  • Finally, we discuss the possibility that TRPM channels may provide therapeutic targets for degenerative diseases involving oxidative stress-related pathologies including diabetes and Alzheimer's disease [4].

High impact information on TRPM1

  • In Caenorhabditis elegans, the melastatin-type transient receptor potential (TRPM) channel, especially TRPM7, was suggested as being involved in defecation rhythm [5].
  • TRPM5, a member of the TRPM subfamily, plays an important role in taste receptors, although its activation mechanism remains controversial and its function in signal transduction is unknown [6].
  • Here, we describe the identification and characterization of an additional TRPM protein TRPM4 [7].
  • The highest homologies are observed with the human TRPC7 and with melastatin 1 ( MLSN1 ), whose transcript is downregulated in metastatic melanomas [8].
  • Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression [8].

Chemical compound and disease context of TRPM1


Biological context of TRPM1


Anatomical context of TRPM1


Associations of TRPM1 with chemical compounds

  • We reveal that TRPM4 and MLSN each mediate Ca(2+) entry when expressed in HEK293 cells [7].
  • TRPM proteins, consisting of six putative transmembrane domains and intracellular N and C termini, form monovalent-permeable cation channels with variable selectivity for Ca(2+), Mg(2+) and other divalent cations [14].
  • HMBA appears to up-regulate MLSN1 transcripts derived mainly from the 5'-end [9].
  • Incorporation of negative charge in place of Gln-981 between the pore helix and selectivity filter by changing it to glutamate, which is present in the more Ca(2+)-permeable TRPM channels, substantially increased Ca(2+) permeability [15].

Regulatory relationships of TRPM1

  • This prompted examination of whether MITF also might transcriptionally regulate TRPM1 expression [1].

Other interactions of TRPM1

  • Mice homozygously mutated in MITF showed a dramatic decrease in TRPM1 expression [1].
  • TRPM2 proteins belong to the melastatin-related transient receptor potential or TRPM subfamily and form Ca(2+)-permeable cationic channels activated by intracellular adenosine diphosphoribose (ADPR) [16].
  • TRPM3, a member of the melastatin-like transient receptor potential channel subfamily (TRPM), is predominantly expressed in human kidney and brain [17].
  • Among the two other TRP subfamilies, TRPMV and TRPM, at least TRPV4 and TRPM4 are EC channels [18].
  • TRPM (transient receptor potential melastatin-like) channels are distinct from many other members of the transient receptor potential family in regard to their overall size (>1000 amino acids), the lack of N-terminal ankyrin-like repeats, and hydrophobicity predictions that may allow for more than six transmembrane regions [19].

Analytical, diagnostic and therapeutic context of TRPM1


  1. Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma. Miller, A.J., Du, J., Rowan, S., Hershey, C.L., Widlund, H.R., Fisher, D.E. Cancer Res. (2004) [Pubmed]
  2. Human melastatin 1 (TRPM1) is regulated by MITF and produces multiple polypeptide isoforms in melanocytes and melanoma. Zhiqi, S., Soltani, M.H., Bhat, K.M., Sangha, N., Fang, D., Hunter, J.J., Setaluri, V. Melanoma Res. (2004) [Pubmed]
  3. Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Schlingmann, K.P., Weber, S., Peters, M., Niemann Nejsum, L., Vitzthum, H., Klingel, K., Kratz, M., Haddad, E., Ristoff, E., Dinour, D., Syrrou, M., Nielsen, S., Sassen, M., Waldegger, S., Seyberth, H.W., Konrad, M. Nat. Genet. (2002) [Pubmed]
  4. The role of TRPM channels in cell death. McNulty, S., Fonfria, E. Pflugers Arch. (2005) [Pubmed]
  5. Melastatin-type transient receptor potential channel 7 is required for intestinal pacemaking activity. Kim, B.J., Lim, H.H., Yang, D.K., Jun, J.Y., Chang, I.Y., Park, C.S., So, I., Stanfield, P.R., Kim, K.W. Gastroenterology (2005) [Pubmed]
  6. TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i. Prawitt, D., Monteilh-Zoller, M.K., Brixel, L., Spangenberg, C., Zabel, B., Fleig, A., Penner, R. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform. Xu, X.Z., Moebius, F., Gill, D.L., Montell, C. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  8. Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression. Prawitt, D., Enklaar, T., Klemm, G., Gärtner, B., Spangenberg, C., Winterpacht, A., Higgins, M., Pelletier, J., Zabel, B. Hum. Mol. Genet. (2000) [Pubmed]
  9. Expression and Up-regulation of alternatively spliced transcripts of melastatin, a melanoma metastasis-related gene, in human melanoma cells. Fang, D., Setaluri, V. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  10. Sumoylation of MITF and its related family members TFE3 and TFEB. Miller, A.J., Levy, C., Davis, I.J., Razin, E., Fisher, D.E. J. Biol. Chem. (2005) [Pubmed]
  11. Novel aspects of signaling and ion-homeostasis regulation in immunocytes. The TRPM ion channels and their potential role in modulating the immune response. Perraud, A.L., Knowles, H.M., Schmitz, C. Mol. Immunol. (2004) [Pubmed]
  12. Tissue distribution profiles of the human TRPM cation channel family. Fonfria, E., Murdock, P.R., Cusdin, F.S., Benham, C.D., Kelsell, R.E., McNulty, S. J. Recept. Signal Transduct. Res. (2006) [Pubmed]
  13. Heterogeneity of rat macrophages recognized by monoclonal antibodies: an immunohistochemical and immunoelectron microscopic study. Takeya, M., Hsiao, L., Shimokawa, Y., Takahashi, K. J. Histochem. Cytochem. (1989) [Pubmed]
  14. The mammalian melastatin-related transient receptor potential cation channels: an overview. Kraft, R., Harteneck, C. Pflugers Arch. (2005) [Pubmed]
  15. Identification of pore residues engaged in determining divalent cationic permeation in transient receptor potential melastatin subtype channel 2. Xia, R., Mei, Z.Z., Mao, H.J., Yang, W., Dong, L., Bradley, H., Beech, D.J., Jiang, L.H. J. Biol. Chem. (2008) [Pubmed]
  16. Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function. Mei, Z.Z., Mao, H.J., Jiang, L.H. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  17. Activation of the melastatin-related cation channel TRPM3 [corrected] by D-erythro-sphingosine. Grimm, C., Kraft, R., Schultz, G., Harteneck, C. Mol. Pharmacol. (2005) [Pubmed]
  18. Transient receptor potential channels in endothelium: solving the calcium entry puzzle? Nilius, B., Droogmans, G., Wondergem, R. Endothelium (2003) [Pubmed]
  19. Trafficking and Assembly of the Cold-sensitive TRPM8 Channel. Erler, I., Al-Ansary, D.M., Wissenbach, U., Wagner, T.F., Flockerzi, V., Niemeyer, B.A. J. Biol. Chem. (2006) [Pubmed]
  20. Chromogenic in situ hybridization analysis of melastatin mRNA expression in melanomas from American Joint Committee on Cancer stage I and II patients with recurrent melanoma. Hammock, L., Cohen, C., Carlson, G., Murray, D., Ross, J.S., Sheehan, C., Nazir, T.M., Carlson, J.A. J. Cutan. Pathol. (2006) [Pubmed]
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