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Gene Review

Nckipsd  -  NCK interacting protein with SH3 domain

Mus musculus

Synonyms: 54 kDa VacA-interacting protein, 90 kDa N-WASP-interacting protein, 90 kDa SH3 protein interacting with Nck, AF3P21, DIP1, ...
 
 
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Disease relevance of Nckipsd

  • The identification of both transforming and transactivating activities within ORF-1 is a characteristic of other viral oncogenes and is the first reported for HHV-6 [1].
  • Analysis of several human tumors by PCR revealed ORF-1 DNA sequences in some angioimmunoblastic lymphadenopathies, Hodgkin's and non-Hodgkin's lymphomas and glioblastomas [1].
  • Furthermore, cells expressing ORF-1 protein produced fibrosarcomas when injected into nude mice, whereas control cells, expressing either no ORF-1 protein or C-terminal truncated (after residue 172) ORF-1 protein, were not tumorigenic [1].
  • ORF1 encoded a 212-amino-acid protein (molecular mass, 22.4 kDa) with 56% identity to the immunophilin SlyD protein of Escherichia coli [2].
 

High impact information on Nckipsd

 

Biological context of Nckipsd

  • In this study it is demonstrated that deletion of four of the tRNA-like sequences and ORF1 from the virus genome does not affect the ability of MHV-68 to replicate in vitro or to establish, and reactivate from, latency in vivo [5].
  • Dip1 contained a PPXY motif, and its domain organization was similar to that of the splicing factor FBP21 in that it possessed one zinc finger and two WW domains [6].
  • Pigs vaccinated with ORF1 or ORF4 were primed for antibody response against NSP2 or GP4, respectively [7].
 

Analytical, diagnostic and therapeutic context of Nckipsd

References

  1. Human herpesvirus 6 (HHV-6) ORF-1 transactivating gene exhibits malignant transforming activity and its protein binds to p53. Kashanchi, F., Araujo, J., Doniger, J., Muralidhar, S., Hoch, R., Khleif, S., Mendelson, E., Thompson, J., Azumi, N., Brady, J.N., Luppi, M., Torelli, G., Rosenthal, L.J. Oncogene (1997) [Pubmed]
  2. Cloning and characterization of two immunophilin-like genes, ilpA and fkpA, on a single 3.9-kilobase fragment of Aeromonas hydrophila genomic DNA. Wong, C.Y., Heuzenroeder, M.W., Quinn, D.M., Flower, R.L. J. Bacteriol. (1997) [Pubmed]
  3. The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein. de Bernard, M., Moschioni, M., Napolitani, G., Rappuoli, R., Montecucco, C. EMBO J. (2000) [Pubmed]
  4. Dysfunction of the Orleans reeler gene arising from exon skipping due to transposition of a full-length copy of an active L1 sequence into the skipped exon. Takahara, T., Ohsumi, T., Kuromitsu, J., Shibata, K., Sasaki, N., Okazaki, Y., Shibata, H., Sato, S., Yoshiki, A., Kusakabe, M., Muramatsu, M., Ueki, M., Okuda, K., Hayashizaki, Y. Hum. Mol. Genet. (1996) [Pubmed]
  5. Four tRNA-like sequences and a serpin homologue encoded by murine gammaherpesvirus 68 are dispensable for lytic replication in vitro and latency in vivo. Simas, J.P., Bowden, R.J., Paige, V., Efstathiou, S. J. Gen. Virol. (1998) [Pubmed]
  6. Role of nuclear WW domains and proline-rich proteins in dinoflagellate transcription. Guillebault, D., Derelle, E., Bhaud, Y., Moreau, H. Protist (2001) [Pubmed]
  7. DNA vaccination of pigs with open reading frame 1-7 of PRRS virus. Barfoed, A.M., Blixenkrone-Møller, M., Jensen, M.H., Bøtner, A., Kamstrup, S. Vaccine (2004) [Pubmed]
 
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