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Gene Review

OR5AC2  -  olfactory receptor, family 5, subfamily AC...

Homo sapiens

Synonyms: HSA1, Olfactory receptor 5AC2
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High impact information on OR5AC2

  • Further, FISH studies of the homologous chromosomal regions in macaque and orangutan revealed that the region represented by HSA BAC RP11-696P19, which spans the inversion breakpoint on HSA 16q11-12, was derived from the ancestral primate chromosome homologous to HSA 1 [1].
  • The diverse phylogenetic occurrence of a single Hsa1 synteny among the major clades of placental mammals suggests that human chromosome 1 represents an intact ancestral chromosome, which was variously fissioned in the majority of placental species [2].
  • In order to find the human homolog of the SAII gene, we transferred HSA1 and HSA9 to an anchorage-independent and tumorigenic Syrian hamster BHK 191-5C cell line by microcell fusion [3].
  • The transfer of HSAX or HSA1, on the other hand, affected neither of these phenotypes [3].
  • Furthermore the SSC2q pericentromeric region was shown to be homologous to another human chromosome (HSA1) [4].

Biological context of OR5AC2

  • Comparative analysis revealed that gene order is very well conserved across SSC4 compared to both HSA1 and HSA8 [5].
  • No remnants of the HSA1 centromere were detected on the corresponding region on SSC4 and traces from the centromeric region of SSC4 cannot clearly be revealed on the homologous region on HSA8 [5].
  • The HSA2/8 and 7/10 associations could be the cytogenetic signatures that unite the Xenarthrans, while the HSA1/19p could be a putative signature that links the Afrotheria and Xenarthra [6].
  • In order to select candidate genes responsible for the above traits from the human genome database, precise correspondence between SSC4 and HSA1 is a prerequisite [7].
  • Eighteen bovine EST markers with orthologues on human chromosomes 1 and 2 (HSA1 and HSA2), together with nine microsatellite markers, were typed against the 180 cell lines of the WGRH panel [8].

Anatomical context of OR5AC2

  • These results show that the HSA-1 monoclonal antibody can be used in determining the human origin of blood, tissue, and a variety of other body fluids [9].

Associations of OR5AC2 with chemical compounds

  • Some homology with HSA 1 has been established with the mapping of THH and IVL to BTA 1q4 [10].

Analytical, diagnostic and therapeutic context of OR5AC2


  1. Independent intrachromosomal recombination events underlie the pericentric inversions of chimpanzee and gorilla chromosomes homologous to human chromosome 16. Goidts, V., Szamalek, J.M., de Jong, P.J., Cooper, D.N., Chuzhanova, N., Hameister, H., Kehrer-Sawatzki, H. Genome Res. (2005) [Pubmed]
  2. The origin of human chromosome 1 and its homologs in placental mammals. Murphy, W.J., Frönicke, L., O'Brien, S.J., Stanyon, R. Genome Res. (2003) [Pubmed]
  3. Monochromosome transfers to Syrian hamster BHK cells via microcell fusion provide functional evidence for suppressor genes on human chromosome 9 both for anchorage independence and for tumorigenicity. Islam, M.Q., Islam, K., Levan, G., Horvath, G. Genes Chromosomes Cancer (1995) [Pubmed]
  4. Evolutionary breakpoints through a high-resolution comparative map between porcine chromosomes 2 and 16 and human chromosomes. Lahbib-Mansais, Y., Mompart, F., Milan, D., Leroux, S., Faraut, T., Delcros, C., Yerle, M. Genomics (2006) [Pubmed]
  5. High-resolution comparative mapping of pig Chromosome 4, emphasizing the FAT1 region. Moller, M., Berg, F., Riquet, J., Pomp, D., Archibald, A., Anderson, S., Feve, K., Zhang, Y., Rothschild, M., Milan, D., Andersson, L., Tuggle, C.K. Mamm. Genome (2004) [Pubmed]
  6. Comparative genome maps of the pangolin, hedgehog, sloth, anteater and human revealed by cross-species chromosome painting: further insight into the ancestral karyotype and genome evolution of eutherian mammals. Yang, F., Graphodatsky, A.S., Li, T., Fu, B., Dobigny, G., Wang, J., Perelman, P.L., Serdukova, N.A., Su, W., O'brien, P.C., Wang, Y., Ferguson-Smith, M.A., Volobouev, V., Nie, W. Chromosome Res. (2006) [Pubmed]
  7. Elucidation of correspondence between swine chromosome 4 and human chromosome 1 by assigning 27 genes to the ImpRH map, and development of microsatellites in the proximity of 14 genes. Hiraiwa, H., Sawazaki, T., Suzuki, K., Fujishima-Kanaya, N., Toki, D., Ito, Y., Uenishi, H., Hayashi, T., Awata, T., Yasue, H. Cytogenet. Genome Res. (2003) [Pubmed]
  8. A high-resolution comparative RH map of the telomeric end of bovine chromosome 2 with human chromosomes 1 and 2. Liu, Z., Womack, J.E., Antoniou, E. Cytogenet. Genome Res. (2003) [Pubmed]
  9. A unique epitope on human serum albumin recognized by monoclonal antibody HSA-1: a probe for identification of the human origin of blood or tissue. Benjamin, D.C., Herr, J.C., Sutherland, W.M., Woodward, M.P., DeCourcy, K., Condon, T.P. Hybridoma (1987) [Pubmed]
  10. In situ hybridization of five loci to cattle chromosome 1. Schmutz, S.M., Moker, J.S., Berryere, T.G. Cytogenet. Cell Genet. (1998) [Pubmed]
  11. Mapping of bovine FcgammaR (FCGR) genes by sperm typing allows extended use of human map information. Klungland, H., Gomez-Raya, L., Howard, C.J., Collins, R.A., Rogne, S., Lien, S. Mamm. Genome (1997) [Pubmed]
  12. Development of a comprehensive comparative radiation hybrid map of bovine chromosome 7 (BTA7) versus human chromosomes 1 (HSA1), 5 (HSA5) and 19 (HSA19). Gautier, M., Hayes, H., Bønsdorff, T., Eggen, A. Cytogenet. Genome Res. (2003) [Pubmed]
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