The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

HMG2  -  3-hydroxy-3-methylglutaryl-coenzyme A...

Arabidopsis thaliana

Synonyms: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 2, 3-hydroxy-3-methylglutaryl-CoA reductase 2, F5J6.1, F5J6_1, HMGR2
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on HMG2


Biological context of HMG2

  • HMG1 and HMG2 consist of four exons and three small introns that interrupt the coding sequence at equivalent positions [3].
  • The similarity between the two encoded proteins (HMGR1 and HMGR2) is restricted to the regions corresponding to the membrane and the catalytic domains [3].
  • The hmg2 mutant showed no visible phenotype under normal growth conditions [4].

Anatomical context of HMG2

  • By using a coupled in vitro transcription-translation assay, we show that both HMGR1 and HMGR2 are cotranslationally inserted into endoplasmic reticulum-derived microsomal membranes [3].

Associations of HMG2 with chemical compounds

  • The suppression of hmg1 and the enhancement of hmg2 and hmg3 transcript levels following elicitor treatment or inoculation with the incompatible race parallel the suppression in steroid and stimulation of sesquiterpenoid accumulations observed in earlier investigations [2].
  • The hmg1 and hmg2 mutants were both more sensitive than the wild type (WT) to lovastatin, an inhibitor of HMGR [4].

Other interactions of HMG2

  • HMG1 mRNA is detected in all tissues, whereas the presence of HMG2 mRNA is restricted to young seedlings, roots, and inflorescences [3].

Analytical, diagnostic and therapeutic context of HMG2


WikiGenes - Universities