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Gene Review

HMGCR  -  3-hydroxy-3-methylglutaryl-CoA reductase

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  1. Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. Hernández-Perera, O., Pérez-Sala, D., Navarro-Antolín, J., Sánchez-Pascuala, R., Hernández, G., Díaz, C., Lamas, S. J. Clin. Invest. (1998) [Pubmed]
  2. Suppression of 3-hydroxy-3-methylglutaryl-CoA reductase by low density lipoproteins produced in vitro by lipoprotein lipase action on nonsuppressive very low density lipoproteins. Catapano, A.L., Gianturco, S.H., Kinnunen, P.K., Eisenberg, S., Gotto, A.M., Smith, L.C. J. Biol. Chem. (1979) [Pubmed]
  3. Statin attenuates high glucose-induced and diabetes-induced oxidative stress in vitro and in vivo evaluated by electron spin resonance measurement. Tsubouchi, H., Inoguchi, T., Sonta, T., Sato, N., Sekiguchi, N., Kobayashi, K., Sumimoto, H., Utsumi, H., Nawata, H. Free Radic. Biol. Med. (2005) [Pubmed]
  4. Enhancement of sterol synthesis by the monoterpene perillyl alcohol is unaffected by competitive 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. Cerda, S.R., Wilkinson, J., Branch, S.K., Broitman, S.A. Lipids (1999) [Pubmed]
  5. Effects of a new calf thymus protein on 3-hydroxy-3-methylglutaryl-CoA reductase activity in rat (Rattus bubalus) hepatocyte cells (BRL-3A). Mondola, P., Santillo, M., Santangelo, F., Belfiore, A., Gambardella, P., Bifulco, M. Comp. Biochem. Physiol., B (1992) [Pubmed]
  6. Cholesterol and prostaglandin synthesis by cultured human skin fibroblasts in the Alagille syndrome involving paucity of interlobular bile ducts. Dupont, J., Raulin, J., Gautier, M., Lapous, D., Loriette, C., Kuan, S., Stewart, J., Krumhardt, B. J. Inherit. Metab. Dis. (1989) [Pubmed]
  7. Identification of regulatory oxysterols, 24(S),25-epoxycholesterol and 25-hydroxycholesterol, in cultured fibroblasts. Saucier, S.E., Kandutsch, A.A., Taylor, F.R., Spencer, T.A., Phirwa, S., Gayen, A.K. J. Biol. Chem. (1985) [Pubmed]
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