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Gene Review:

SULTR1;1 - sulfate transporter 1.1

Arabidopsis thaliana

Synonyms: SULTR1.2, sulphate transporter 1;1

Maruyama-Nakashita, A. et al., Maruyama-Nakashita, A. et al., Yoshimoto, N. et al., Maruyama-Nakashita, A. et al., Maruyama-Nakashita, A. et al., et al.

Shibagaki, Grossman,

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High impact information on SULTR1;1

The A. thaliana Sultr1;2 and Sultr1;1 sulfate transporters rescue the methionine-dependent growth phenotype of the yeast sulfate transporter mutant strain CP154-7B [1].
The promoter region of SULTR1;1 was dissected for deletion and gain-of-function analysis using luciferase (LUC) reporter gene in transgenic Arabidopsis [2].
The 16-bp sulfur-responsive element (SURE) from -2777 to -2762 of SULTR1;1 promoter was sufficient and necessary for the -S-responsive expression, which was reversed when supplied with cysteine and glutathione (GSH) [2].
Downregulation of SULTR1;1 and SULTR1;2 by cytokinin correlated with the decrease in sulfate uptake activities in roots [3].
The sulfate content of the mutant was 10% to 20% of the wild type, suggesting that induction of SULTR1;1 is not fully complementing the function of SULTR1;2 and that SULTR1;2 serves as the major facilitator for the acquisition of sulfate in Arabidopsis roots [4].

Biological context of SULTR1;1

The abundance of SULTR1;1 mRNA was significantly increased in the sel1-10 mutant; however, this compensatory up-regulation of SULTR1;1 was not sufficient to restore the growth [4].
The regulatory mechanism of SULTR1;1 expression was studied using inhibitors for transcription, translation, protein phosphorylation and dephosphorylation [5].

Associations of SULTR1;1 with chemical compounds

SULTR1;1 conducting sulfate uptake in sultr1;2 mutant was similarly downregulated by cytokinin [3].
In addition, the induction of SULTR1;1 by -S was significantly blocked by okadaic acid (OKA) and calyculin A (CalyA) [5].
The induction of SULTR1;1 mRNA during -S was blocked by the addition of actinomycin D in the medium, suggesting that SULTR1;1 is transcriptionally regulated [5].
Cycloheximide repressed the -S induction of SULTR1;1, but enhanced the basal mRNA level of SULTR1;1 under sulfur replete (+S) condition [5].
Addition of selenate to the medium increased the level of Sultr1;1 mRNA in parallel with a decrease in the internal sulfate pool in roots [6].

Other interactions of SULTR1;1

The abundance of Sultr1;1 and Sultr2;1 mRNA was increased remarkably in roots by short-term stress caused by withdrawal of sulphate [7].
These results suggested that the up-regulation of SULTR1;1 by -S requires protein phosphatase as an upstream regulatory factor [5].
Antisense plants of Sultr1;1 showed reduced accumulation of sulfate in roots, particularly in plants treated with selenate, suggesting that the inducible transporter Sultr1;1 contributes to the uptake of sulfate under stressed conditions [6].

References

Probing the function of STAS domains of the Arabidopsis sulfate transporters. Shibagaki, N., Grossman, A.R. J. Biol. Chem. (2004) [Pubmed]
Identification of a novel cis-acting element conferring sulfur deficiency response in Arabidopsis roots. Maruyama-Nakashita, A., Nakamura, Y., Watanabe-Takahashi, A., Inoue, E., Yamaya, T., Takahashi, H. Plant J. (2005) [Pubmed]
A novel regulatory pathway of sulfate uptake in Arabidopsis roots: implication of CRE1/WOL/AHK4-mediated cytokinin-dependent regulation. Maruyama-Nakashita, A., Nakamura, Y., Yamaya, T., Takahashi, H. Plant J. (2004) [Pubmed]
Transcriptome profiling of sulfur-responsive genes in Arabidopsis reveals global effects of sulfur nutrition on multiple metabolic pathways. Maruyama-Nakashita, A., Inoue, E., Watanabe-Takahashi, A., Yamaya, T., Takahashi, H. Plant Physiol. (2003) [Pubmed]
Induction of SULTR1;1 sulfate transporter in Arabidopsis roots involves protein phosphorylation/dephosphorylation circuit for transcriptional regulation. Maruyama-Nakashita, A., Nakamura, Y., Watanabe-Takahashi, A., Yamaya, T., Takahashi, H. Plant Cell Physiol. (2004) [Pubmed]
Two distinct high-affinity sulfate transporters with different inducibilities mediate uptake of sulfate in Arabidopsis roots. Yoshimoto, N., Takahashi, H., Smith, F.W., Yamaya, T., Saito, K. Plant J. (2002) [Pubmed]
The roles of three functional sulphate transporters involved in uptake and translocation of sulphate in Arabidopsis thaliana. Takahashi, H., Watanabe-Takahashi, A., Smith, F.W., Blake-Kalff, M., Hawkesford, M.J., Saito, K. Plant J. (2000) [Pubmed]

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SULTR1;2	Arabidopsis thaliana
SULTR1;3	Arabidopsis thaliana
Os03g0195800	Oryza sativa Japonica Group
Os03g0196000	Oryza sativa Japonica Group

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