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PLVAP  -  plasmalemma vesicle associated protein

Homo sapiens

Synonyms: FELS, Fenestrated endothelial-linked structure protein, PV-1, PV1, Plasmalemma vesicle protein 1, ...
 
 
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Disease relevance of PLVAP

 

Psychiatry related information on PLVAP

 

High impact information on PLVAP

  • Immunocytochemical studies carried out by immunodiffusion on rat lung with an anti-PV-1 polyclonal antibody directed against a COOH-terminal epitope reveal a specific localization of PV-1 to the stomatal diaphragms of rat lung endothelial caveolae and confirm the extracellular orientation of the PV-1 COOH terminus [2].
  • From the Cover: An in vitro assay reveals a role for the diaphragm protein PV-1 in endothelial fenestra morphogenesis [3].
  • As the expression of this molecule is by no means restricted to fenestrated endothelium, we suggest the use of the name PLVAP for this protein [4].
 

Chemical compound and disease context of PLVAP

 

Biological context of PLVAP

  • The aim of this study was to characterize the expression pattern of PLVAP and investigate whether PLVAP is a transcriptional target of VEGF signal transduction [5].
  • The upregulation of PV1 and formation of stomatal and fenestral diaphragms by PMA was endothelium specific and was the highest in microvascular endothelial cells compared with their large vessel counterparts [6].
  • Taken together, these data show that PV1 is a key structural component, necessary for the biogenesis of the stomatal and fenestral diaphragms [6].
  • RNA interference-mediated inhibition of PV-1 induction in HMVEC cells blocked Matrigel-induced tubulogenesis and inhibited cell migration induced by conditioned medium or angiogenic growth factors [1].
  • In the adult testis, strong PV-1 expression was seen in germ cells within the seminiferous tubules that varied with the stage of spermatogenesis [7].
 

Anatomical context of PLVAP

 

Associations of PLVAP with chemical compounds

  • PV1 is an endothelial-specific integral membrane glycoprotein associated with the stomatal diaphragms of caveolae, transendothelial channels, and vesiculo-vacuolar organelles and the diaphragms of endothelial fenestrae [6].
 

Other interactions of PLVAP

  • We suggest that PLVAP is a downstream target of VEGF signalling [5]
 

Analytical, diagnostic and therapeutic context of PLVAP

References

  1. Plasmalemmal vesicle associated protein-1 is a novel marker implicated in brain tumor angiogenesis. Carson-Walter, E.B., Hampton, J., Shue, E., Geynisman, D.M., Pillai, P.K., Sathanoori, R., Madden, S.L., Hamilton, R.L., Walter, K.A. Clin. Cancer Res. (2005) [Pubmed]
  2. Isolation, cloning, and localization of rat PV-1, a novel endothelial caveolar protein. Stan, R.V., Ghitescu, L., Jacobson, B.S., Palade, G.E. J. Cell Biol. (1999) [Pubmed]
  3. From the Cover: An in vitro assay reveals a role for the diaphragm protein PV-1 in endothelial fenestra morphogenesis. Ioannidou, S., Deinhardt, K., Miotla, J., Bradley, J., Cheung, E., Samuelsson, S., Ng, Y.S., Shima, D.T. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. Molecular identification of PAL-E, a widely used endothelial-cell marker. Niemelä, H., Elima, K., Henttinen, T., Irjala, H., Salmi, M., Jalkanen, S. Blood (2005) [Pubmed]
  5. Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF). Strickland, L.A., Jubb, A.M., Hongo, J.A., Zhong, F., Burwick, J., Fu, L., Frantz, G.D., Koeppen, H. J. Pathol. (2005) [Pubmed]
  6. PV1 is a key structural component for the formation of the stomatal and fenestral diaphragms. Stan, R.V., Tkachenko, E., Niesman, I.R. Mol. Biol. Cell (2004) [Pubmed]
  7. Distribution and characterization of plasmalemma vesicle protein-1 in rat endocrine glands. Hnasko, R., McFarland, M., Ben-Jonathan, N. J. Endocrinol. (2002) [Pubmed]
 
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