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Gene Review

NP1  -  mitogen-activated protein kinase kinase...

Arabidopsis thaliana

Synonyms: ANP1, F7G19.13, F7G19_13, MAP KINASE KINASE KINASE 1, MAPKKK1, ...
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High impact information on ANP1

  • Unlike effectors of mammalian pathogens, AvrPto and AvrPtoB intercept multiple MAMP-mediated signaling upstream of MAPKKK at the plasma membrane linked to the receptor [1].
  • Specific Bacterial Suppressors of MAMP Signaling Upstream of MAPKKK in Arabidopsis Innate Immunity [1].
  • We have identified a MAPKK kinase gene, named YODA, that promotes extra-embryonic cell fates in the basal lineage [2].
  • Expansion of the cell plate in plant cytokinesis requires a kinesin-like protein/MAPKKK complex [3].
  • Here we show that a specific plant MAPKKK, NPK1, activates a MAPK cascade that leads to the suppression of early auxin response gene transcription [4].

Biological context of ANP1


Associations of ANP1 with chemical compounds


Other interactions of ANP1

  • When MEK1 was expressed at a low level, rescue of Deltawis1 was achieved by co-expressing Arabidopsis CTR1 (a putative MAPKK kinase (MAPKKK)) [10].
  • One is the two-hybrid screening of ATMEKK1 (a MAPKKK)-interacting proteins; the other is an analysis of physical and functional interactions among isolated MAPK, MAPKK, and MAPKKK homologues from Arabidopsis [11].


  1. Specific Bacterial Suppressors of MAMP Signaling Upstream of MAPKKK in Arabidopsis Innate Immunity. He, P., Shan, L., Lin, N.C., Martin, G.B., Kemmerling, B., Nürnberger, T., Sheen, J. Cell (2006) [Pubmed]
  2. A MAPKK kinase gene regulates extra-embryonic cell fate in Arabidopsis. Lukowitz, W., Roeder, A., Parmenter, D., Somerville, C. Cell (2004) [Pubmed]
  3. Expansion of the cell plate in plant cytokinesis requires a kinesin-like protein/MAPKKK complex. Nishihama, R., Soyano, T., Ishikawa, M., Araki, S., Tanaka, H., Asada, T., Irie, K., Ito, M., Terada, M., Banno, H., Yamazaki, Y., Machida, Y. Cell (2002) [Pubmed]
  4. Suppression of auxin signal transduction by a MAPK cascade in higher plants. Kovtun, Y., Chiu, W.L., Zeng, W., Sheen, J. Nature (1998) [Pubmed]
  5. Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants. Kovtun, Y., Chiu, W.L., Tena, G., Sheen, J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  6. An Arabidopsis mitogen-activated protein kinase kinase kinase gene family encodes essential positive regulators of cytokinesis. Krysan, P.J., Jester, P.J., Gottwald, J.R., Sussman, M.R. Plant Cell (2002) [Pubmed]
  7. A Mitogen-activated Protein Kinase Kinase Kinase Mediates Reactive Oxygen Species Homeostasis in Arabidopsis. Nakagami, H., Soukupov??, H., Schikora, A., Z??rsky, V., Hirt, H. J. Biol. Chem. (2006) [Pubmed]
  8. The atypical resistance gene, RPW8, recruits components of basal defence for powdery mildew resistance in Arabidopsis. Xiao, S., Calis, O., Patrick, E., Zhang, G., Charoenwattana, P., Muskett, P., Parker, J.E., Turner, J.G. Plant J. (2005) [Pubmed]
  9. Loss-of-function mutations in the ethylene receptor ETR1 cause enhanced sensitivity and exaggerated response to ethylene in Arabidopsis. Cancel, J.D., Larsen, P.B. Plant Physiol. (2002) [Pubmed]
  10. Functional complementation of the Schizosaccharomyces pombe wis1 mutant by Arabidopsis MEK1 and non-catalytic enhancement by CTR1. Pan, Z., Chang, C. FEBS Lett. (1999) [Pubmed]
  11. Isolation of ATMEKK1 (a MAP kinase kinase kinase)-interacting proteins and analysis of a MAP kinase cascade in Arabidopsis. Ichimura, K., Mizoguchi, T., Irie, K., Morris, P., Giraudat, J., Matsumoto, K., Shinozaki, K. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
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