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Gene Review

Flot2  -  flotillin 2

Rattus norvegicus

Synonyms: Flotillin-2, REG-1, Reg1, Reggie-1
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Disease relevance of Flot2

  • Antibodies (ABs) which recognize reggie-1 or -2 reveal that both proteins cluster at the plasmamembrane and occur in micropatches in neurons [dorsal root ganglia (DRGs), retinal ganglion, and PC-12 cells] and in nonneuronal cells [1].
  • We first found REG-1 protein expression in human hearts obtained from autopsied patients who died of myocardial infarction [2].

High impact information on Flot2


Biological context of Flot2


Anatomical context of Flot2

  • By quantitative electronmicroscopic analysis we demonstrate the absence of caveolae in (anti-caveolin negative) neurons and show anti-reggie-1 immunogold-labeled clusters at the plasmamembrane of DRGs [1].
  • In neurons, reggie micropatches occur along the axon and in lamellipodia and filopodia of growth cones, but they do not occur in caveolae [1].
  • Here we show that the preformed reggie/flotillin caps present in resting T cells act as priming platforms for macrodomain assembly [4].
  • Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression [5].
  • Overexpression of reggie-1 resulted in the induction of numerous filopodia-like protrusions in various cell lines, suggesting a role for reggie-1 as a signalling protein in actin-dependent processes [5].

Associations of Flot2 with chemical compounds

  • Accordingly, expression of the trans-negative reggie-1 mutant leads to the incorrect positioning of the guanine nucleotide exchange factor Vav, resulting in defects in cytoskeletal reorganization [4].

Physical interactions of Flot2

  • Thus, the preformed reggie/flotillin caps are stable priming platforms for the assembly of multiprotein complexes controlling actin reorganization during T cell activation [4].

Other interactions of Flot2


Analytical, diagnostic and therapeutic context of Flot2


  1. Identification of reggie-1 and reggie-2 as plasmamembrane-associated proteins which cocluster with activated GPI-anchored cell adhesion molecules in non-caveolar micropatches in neurons. Lang, D.M., Lommel, S., Jung, M., Ankerhold, R., Petrausch, B., Laessing, U., Wiechers, M.F., Plattner, H., Stuermer, C.A. J. Neurobiol. (1998) [Pubmed]
  2. Activation of regenerating gene Reg in rat and human hearts in response to acute stress. Kiji, T., Dohi, Y., Takasawa, S., Okamoto, H., Nonomura, A., Taniguchi, S. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  3. Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2. Stuermer, C.A., Lang, D.M., Kirsch, F., Wiechers, M., Deininger, S.O., Plattner, H. Mol. Biol. Cell (2001) [Pubmed]
  4. Preformed reggie/flotillin caps: stable priming platforms for macrodomain assembly in T cells. Langhorst, M.F., Reuter, A., Luxenhofer, G., Boneberg, E.M., Legler, D.F., Plattner, H., Stuermer, C.A. FASEB J. (2006) [Pubmed]
  5. Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression. Neumann-Giesen, C., Falkenbach, B., Beicht, P., Claasen, S., Lüers, G., Stuermer, C.A., Herzog, V., Tikkanen, R. Biochem. J. (2004) [Pubmed]
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