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Dnaja3  -  DnaJ (Hsp40) homolog, subfamily A, member 3

Mus musculus

Synonyms: 1200003J13Rik, 1810053A11Rik, C81173, DnaJ homolog subfamily A member 3, mitochondrial, DnaJ protein Tid-1, ...
 
 
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Disease relevance of Dnaja3

  • Mice deficient in Dnaja3 developed dilated cardiomyopathy (DCM) and died before 10 weeks of age [1].
  • Here we report that the mitochondrial chaperone Hsp40, also known as Dnaja3 or Tid1, is differentially expressed during cardiac development and pathological hypertrophy [1].
  • We show that GSE-Tid1 enhances immortalization by human papillomavirus E7 and simian virus 40 T antigen and cooperates with activated ras for transformation [2].
 

High impact information on Dnaja3

  • Progressive respiratory chain deficiency and decreased copy number of mitochondrial DNA were evident in cardiomyocytes lacking Dnaja3 [1].
  • 5. To assess the function of Tid1 in embryonic cells, mouse embryonic fibroblasts with the homologous Tid1 floxed allele were produced [3].
  • Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor l(2)tid, is critical for early embryonic development and cell survival [3].
  • Nonetheless, Tid1-deficient blastocysts were viable, hatched, formed an inner cell mass and trophectoderm, and implanted (E4.5), suggesting that the homozygous mutant embryos die between E4.5 and E7 [3].
  • Tid1 removal in these cells led to massive cell death [3].
 

Biological context of Dnaja3

 

Anatomical context of Dnaja3

References

  1. A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy. Hayashi, M., Imanaka-Yoshida, K., Yoshida, T., Wood, M., Fearns, C., Tatake, R.J., Lee, J.D. Nat. Med. (2006) [Pubmed]
  2. Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival. Tarunina, M., Alger, L., Chu, G., Munger, K., Gudkov, A., Jat, P.S. Mol. Cell. Biol. (2004) [Pubmed]
  3. Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor l(2)tid, is critical for early embryonic development and cell survival. Lo, J.F., Hayashi, M., Woo-Kim, S., Tian, B., Huang, J.F., Fearns, C., Takayama, S., Zapata, J.M., Yang, Y., Lee, J.D. Mol. Cell. Biol. (2004) [Pubmed]
  4. A mouse homologue of the Drosophila tumor suppressor l(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein. Trentin, G.A., Yin, X., Tahir, S., Lhotak, S., Farhang-Fallah, J., Li, Y., Rozakis-Adcock, M. J. Biol. Chem. (2001) [Pubmed]
 
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