Disease relevance of TNS4

• We attempted to determine the influence of cten expression on clinicopathological features in patients with lung cancer who had undergone surgery [1].
• Expression of cten messenger RNA was evaluated by reverse transcription-polymerase chain reaction (RT-PCR) in 89 lung carcinomas and adjacent histological normal lung samples using LightCycler [1].
• Furthermore, examination of cten expression in prostate cancer/cell lines has revealed its down-regulation in tumor samples [2].
• We report that cten binds to another tumor suppressor, deleted in liver cancer 1 (DLC-1), and the SH2 domain of cten is responsible for the interaction [3].

High impact information on TNS4

• These results provide a novel mechanism whereby the SH2 domain of cten-mediated focal adhesion localization of DLC-1 plays an essential role in its tumor suppression activity [3].
• Unexpectedly, the interaction between DLC-1 and the cten SH2 domain is independent of tyrosine phosphorylation of DLC-1 [3].
• Human cten cDNA encodes a 715 amino acid sequence containing the Src homology 2 and phosphotyrosine-binding domains that are similar to the COOH termini of tensin molecules [2].
• Our studies have suggested that during evolution, cten has preserved its role in mediating signal transduction at focal adhesions through the Src homology 2 and phosphotyrosine-binding domains but has lost its function in binding to actin filaments [2].
• Here, we have explored the potential roles of cten in apoptosis [4].

Anatomical context of TNS4

• Cten is a recently isolated gene, which has homology with tensin suggesting that it is a focal adhesion molecule [1].
• In contrast to other tensins, cten expression is limited to very few tissues, such as the prostate, and only in epithelial cells [4].

Regulatory relationships of TNS4

• Detection of cleaved poly(ADP-ribose) polymerase and annexin binding in cells expressing cten (571-715) indicated that a fraction of cells underwent apoptosis [4].
• Treatment of inflammatory breast cancer patients with an EGFR/HER2 dual-specificity kinase inhibitor significantly downregulated cten expression [5].

Other interactions of TNS4

• There was no relationship between cten/GAPDH expression and age, gender or N-status [1].
• We attempted to determine the influence of cten expression on clinicopathological features in patients with thymoma who had undergone surgery [6].

Analytical, diagnostic and therapeutic context of TNS4

• In contrast to other tensin members, cten expression is restricted to prostate and placenta by Northern blot analysis [2].
• By using recombinant caspases and site-directed mutagenesis, we have identified caspase-3 as the major protease to digest cten at the DSTD(570 downward arrow)S site [4].

References