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Gene Review

TNS4  -  tensin 4

Homo sapiens

Synonyms: C-terminal tensin-like protein, CTEN, PP14434, Tensin-4
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Disease relevance of TNS4

  • We attempted to determine the influence of cten expression on clinicopathological features in patients with lung cancer who had undergone surgery [1].
  • Expression of cten messenger RNA was evaluated by reverse transcription-polymerase chain reaction (RT-PCR) in 89 lung carcinomas and adjacent histological normal lung samples using LightCycler [1].
  • Furthermore, examination of cten expression in prostate cancer/cell lines has revealed its down-regulation in tumor samples [2].
  • We report that cten binds to another tumor suppressor, deleted in liver cancer 1 (DLC-1), and the SH2 domain of cten is responsible for the interaction [3].

High impact information on TNS4


Anatomical context of TNS4

  • Cten is a recently isolated gene, which has homology with tensin suggesting that it is a focal adhesion molecule [1].
  • In contrast to other tensins, cten expression is limited to very few tissues, such as the prostate, and only in epithelial cells [4].

Regulatory relationships of TNS4


Other interactions of TNS4

  • There was no relationship between cten/GAPDH expression and age, gender or N-status [1].
  • We attempted to determine the influence of cten expression on clinicopathological features in patients with thymoma who had undergone surgery [6].

Analytical, diagnostic and therapeutic context of TNS4

  • In contrast to other tensin members, cten expression is restricted to prostate and placenta by Northern blot analysis [2].
  • By using recombinant caspases and site-directed mutagenesis, we have identified caspase-3 as the major protease to digest cten at the DSTD(570 downward arrow)S site [4].


  1. Cten mRNA expression was correlated with tumor progression in lung cancers. Sasaki, H., Moriyama, S., Mizuno, K., Yukiue, H., Konishi, A., Yano, M., Kaji, M., Fukai, I., Kiriyama, M., Yamakawa, Y., Fujii, Y. Lung Cancer (2003) [Pubmed]
  2. Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer. Lo, S.H., Lo, T.B. Cancer Res. (2002) [Pubmed]
  3. The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1. Liao, Y.C., Si, L., Devere White, R.W., Lo, S.H. J. Cell Biol. (2007) [Pubmed]
  4. Cleavage of cten by caspase-3 during apoptosis. Lo, S.S., Lo, S.H., Lo, S.H. Oncogene (2005) [Pubmed]
  5. A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration. Katz, M., Amit, I., Citri, A., Shay, T., Carvalho, S., Lavi, S., Milanezi, F., Lyass, L., Amariglio, N., Jacob-Hirsch, J., Ben-Chetrit, N., Tarcic, G., Lindzen, M., Avraham, R., Liao, Y.C., Trusk, P., Lyass, A., Rechavi, G., Spector, N.L., Lo, S.H., Schmitt, F., Bacus, S.S., Yarden, Y. Nat. Cell Biol. (2007) [Pubmed]
  6. Cten mRNA expression is correlated with tumor progression in thymoma. Sasaki, H., Yukiue, H., Kobayashi, Y., Fukai, I., Fujii, Y. Tumour Biol. (2003) [Pubmed]
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