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Gene Review

SPR3  -  septin SPR3

Saccharomyces cerevisiae S288c

Synonyms: Sporulation-regulated protein 3, YGR059W
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Disease relevance of SPR3


High impact information on SPR3

  • Deletion of SPR3 does not prevent the localization of Cdc3p and Cdc11p, but these proteins appear to be less well organized, and the intensity of their staining is reduced [2].
  • In one genetic background, deletion of SPR3 produced a threefold reduction in sporulation efficiency, although meiosis appeared to be completed normally [2].
  • The predicted SPR3 product shows 25-40% identity in amino acid sequence to the previously known septins from S. cerevisiae and other organisms [2].
  • The SPR3 gene encodes a sporulation-specific homolog of the yeast Cdc3/10/11/12 family of bud neck filament proteins [3].
  • A palindromic sequence located near the TATA box is essential to the developmental regulation of this gene and is the only element directly activating SPR3 at the right time during sporulation [3].

Biological context of SPR3


Anatomical context of SPR3

  • The SPR3 gene encodes a sporulation-specific homologue of the yeast CDC3/10/11/12 family of bud neck microfilaments and is regulated by ABFI [4].

Other interactions of SPR3

  • We conclude that SPR1, SPR2 and SPR3 transcription is modulated during sporulation, possibly in response to earlier events in the process [1].
  • Deletion of SPR28 in either a wild-type or an spr3 delta background produced no obvious abnormalities in vegetative cells and had little or no effect on sporulation, suggesting that the septins have redundant roles during spore formation [5].

Analytical, diagnostic and therapeutic context of SPR3


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