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Gene Review

CLB6  -  Clb6p

Saccharomyces cerevisiae S288c

Synonyms: G5970, S-phase entry cyclin-6, YGR109C
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Disease relevance of CLB6

  • Clb6-dependent toxicity is also relieved when early accumulation of mitotic cyclins is allowed to impose rereplication controls [1].

High impact information on CLB6


Biological context of CLB6

  • Although cells that lack clb5 and clb6 are unable to activate the meiotic DNA replication checkpoint, they do possess an intact DNA damage checkpoint which can restrain chromosome segregation in the face of DNA damage [3].
  • Further studies reveal that the accumulation of G(1) cyclin transcripts is markedly delayed in the clb5 clb6 mutant following heat shock treatment, indicating that the CLN gene expression may require Clb5/Clb6 to attain a threshold level for driving the cell cycle through G(1)/S transition [6].
  • Occasionally, misplaced spindles were observed in cdc28-4 clb5 haploids; additional deletion of CLB6 caused full penetrance [7].
  • The consequences of this negative regulation were most apparent in clb6 mutants, which had a shorter pre-Start G1 phase as well as a shorter G2 phase than congenic wild-type cells [8].
  • B-type cyclins CLB5 and CLB6 control the initiation of recombination and synaptonemal complex formation in yeast meiosis [9].

Other interactions of CLB6


  1. Cyclin and cyclin-dependent kinase substrate requirements for preventing rereplication reveal the need for concomitant activation and inhibition. Ikui, A.E., Archambault, V., Drapkin, B.J., Campbell, V., Cross, F.R. Genetics (2007) [Pubmed]
  2. Regulation of meiotic S phase by Ime2 and a Clb5,6-associated kinase in Saccharomyces cerevisiae. Dirick, L., Goetsch, L., Ammerer, G., Byers, B. Science (1998) [Pubmed]
  3. CLB5 and CLB6 are required for premeiotic DNA replication and activation of the meiotic S/M checkpoint. Stuart, D., Wittenberg, C. Genes Dev. (1998) [Pubmed]
  4. CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae. Schwob, E., Nasmyth, K. Genes Dev. (1993) [Pubmed]
  5. Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6. Jackson, L.P., Reed, S.I., Haase, S.B. Mol. Cell. Biol. (2006) [Pubmed]
  6. Recovery of the yeast cell cycle from heat shock-induced G(1) arrest involves a positive regulation of G(1) cyclin expression by the S phase cyclin Clb5. Li, X., Cai, M. J. Biol. Chem. (1999) [Pubmed]
  7. Clb5-associated kinase activity is required early in the spindle pathway for correct preanaphase nuclear positioning in Saccharomyces cerevisiae. Segal, M., Clarke, D.J., Reed, S.I. J. Cell Biol. (1998) [Pubmed]
  8. Negative regulation of G1 and G2 by S-phase cyclins of Saccharomyces cerevisiae. Basco, R.D., Segal, M.D., Reed, S.I. Mol. Cell. Biol. (1995) [Pubmed]
  9. B-type cyclins CLB5 and CLB6 control the initiation of recombination and synaptonemal complex formation in yeast meiosis. Smith, K.N., Penkner, A., Ohta, K., Klein, F., Nicolas, A. Curr. Biol. (2001) [Pubmed]
  10. Clb6/Cdc28 and Cdc14 regulate phosphorylation status and cellular localization of Swi6. Geymonat, M., Spanos, A., Wells, G.P., Smerdon, S.J., Sedgwick, S.G. Mol. Cell. Biol. (2004) [Pubmed]
  11. S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state. Dahmann, C., Diffley, J.F., Nasmyth, K.A. Curr. Biol. (1995) [Pubmed]
  12. The sequence of a 23.4 kb segment on the right arm of chromosome VII from Saccharomyces cerevisiae reveals CLB6, SPT6, RP28A and NUP57 genes, a Ty3 element and 11 new open reading frames. Hansen, M., Albers, M., Backes, U., Coblenz, A., Leuther, H., Neu, R., Schreer, A., Schäfer, B., Zimmermann, M., Wolf, K. Yeast (1996) [Pubmed]
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