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Gene Review

TAH11  -  Tah11p

Saccharomyces cerevisiae S288c

Synonyms: CDT1, Cell division cycle protein CDT1, J1641, SIC1 indispensable protein 2, SID2, ...
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High impact information on TAH11

  • Inhibiting Cdc6 ATP hydrolysis stabilizes Cdt1 on origin DNA and prevents Mcm2-7 loading [1].
  • Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase [2].
  • Cdc18 expression in G2 induces DNA synthesis by re-firing replication origins and recruiting the MCM Cdc21 to chromatin in the presence of low levels of Cdt1 [3].
  • Thus, regulation of both Cdc18 and Cdt1 in G2 plays a crucial role in preventing the re-initiation of DNA synthesis until the next cell cycle [3].
  • These genes locate to three gene clusters on different chromosomes and include the previously identified complementing siderophore auxotroph genes sid1 and sid2 involved in siderophore biosynthesis [4].

Biological context of TAH11


Anatomical context of TAH11


Physical interactions of TAH11


Regulatory relationships of TAH11

  • We also demonstrate that mob1p can be precipitated from cells in a complex with the septation regulating kinase sid2p [10].

Other interactions of TAH11

  • We conclude that origin licensing depends in S. cerevisiae as in other eukaryotes on both Cdc6 and Cdt1 [5].
  • A growing list of proteins, including Mcm10 and Cdt1, are involved in the recruitment process [11].


  1. Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase. Randell, J.C., Bowers, J.L., Rodríguez, H.K., Bell, S.P. Mol. Cell (2006) [Pubmed]
  2. Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase. Tanaka, S., Diffley, J.F. Nat. Cell Biol. (2002) [Pubmed]
  3. Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication. Yanow, S.K., Lygerou, Z., Nurse, P. EMBO J. (2001) [Pubmed]
  4. A Ferroxidation/Permeation Iron Uptake System Is Required for Virulence in Ustilago maydis. Eichhorn, H., Lessing, F., Winterberg, B., Schirawski, J., K??mper, J., M??ller, P., Kahmann, R. Plant Cell (2006) [Pubmed]
  5. Identification of Tah11/Sid2 as the ortholog of the replication licensing factor Cdt1 in Saccharomyces cerevisiae. Devault, A., Vallen, E.A., Yuan, T., Green, S., Bensimon, A., Schwob, E. Curr. Biol. (2002) [Pubmed]
  6. DNA replication licensing affects cell proliferation or endoreplication in a cell type-specific manner. Castellano, M.d.e.l. .M., Boniotti, M.B., Caro, E., Schnittger, A., Gutierrez, C. Plant Cell (2004) [Pubmed]
  7. Control of DNA replication licensing in a cell cycle. Nishitani, H., Lygerou, Z. Genes Cells (2002) [Pubmed]
  8. Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex. Takahashi, T.S., Yiu, P., Chou, M.F., Gygi, S., Walter, J.C. Nat. Cell Biol. (2004) [Pubmed]
  9. Mob1p interacts with the Sid2p kinase and is required for cytokinesis in fission yeast. Hou, M.C., Salek, J., McCollum, D. Curr. Biol. (2000) [Pubmed]
  10. The S. pombe orthologue of the S. cerevisiae mob1 gene is essential and functions in signalling the onset of septum formation. Salimova, E., Sohrmann, M., Fournier, N., Simanis, V. J. Cell. Sci. (2000) [Pubmed]
  11. Initiating DNA synthesis: from recruiting to activating the MCM complex. Lei, M., Tye, B.K. J. Cell. Sci. (2001) [Pubmed]
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