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Gene Review

PYK2  -  pyruvate kinase PYK2

Saccharomyces cerevisiae S288c

Synonyms: O6342, PK 2, Pyruvate kinase 2, YOR347C
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Disease relevance of PYK2

  • Baculovirus PK2, which resembles the C-terminal half of a protein kinase domain, was found to inhibit both human and yeast eIF2alpha kinases [1].

High impact information on PYK2


Biological context of PYK2

  • A pyk2 deletion mutant had no obvious growth phenotypes under various conditions, but the growth defects of a pyk1 pyk2 double-deletion strain were even more pronounced than those of a pyk1 single-mutation strain [3].
  • The disruption cassettes were used to generate homologous recombinants in two diploid strains with different genetic backgrounds (FY1679 and CEN. PK2), selecting for geneticin (G418) resistance conferred by the presence of the dominant marker kanMX4 [4].
  • Interestingly, the baculovirus gene product, PK2, can inhibit BeK enzymatic activity, suggesting that BeK may be an endogenous target for a viral gene product [5].

Anatomical context of PYK2


Other interactions of PYK2

  • The results indicate that the PYK2-encoded pyruvate kinase may be used under conditions of very low glycolytic flux [3].


  1. Disruption of cellular translational control by a viral truncated eukaryotic translation initiation factor 2alpha kinase homolog. Dever, T.E., Sripriya, R., McLachlin, J.R., Lu, J., Fabian, J.R., Kimball, S.R., Miller, L.K. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. In vivo and in vitro phosphorylation of two isoforms of yeast pyruvate kinase by protein kinase A. Portela, P., Howell, S., Moreno, S., Rossi, S. J. Biol. Chem. (2002) [Pubmed]
  3. Characterization of a glucose-repressed pyruvate kinase (Pyk2p) in Saccharomyces cerevisiae that is catalytically insensitive to fructose-1,6-bisphosphate. Boles, E., Schulte, F., Miosga, T., Freidel, K., Schlüter, E., Zimmermann, F.K., Hollenberg, C.P., Heinisch, J.J. J. Bacteriol. (1997) [Pubmed]
  4. Disruption and phenotypic analysis of six novel genes from chromosome IV of Saccharomyces cerevisiae reveal YDL060w as an essential gene for vegetative growth. Casalone, E., Barberio, C., Cavalieri, D., Ceccarelli, I., Riparbelli, M., Ugolini, S., Polsinelli, M. Yeast (1999) [Pubmed]
  5. Cloning and characterization of an eukaryotic initiation factor-2alpha kinase from the silkworm, Bombyx mori. Prasad, M.D., Han, S.J., Nagaraju, J., Lee, W.J., Brey, P.T. Biochim. Biophys. Acta (2003) [Pubmed]
  6. FAK and PYK2 interact with SAP90/PSD-95-Associated Protein-3. Bongiorno-Borbone, L., Kadaré, G., Benfenati, F., Girault, J.A. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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