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MeSH Review

Substrate Cycling

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Disease relevance of Substrate Cycling


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Chemical compound and disease context of Substrate Cycling


Biological context of Substrate Cycling


Anatomical context of Substrate Cycling


Associations of Substrate Cycling with chemical compounds


Gene context of Substrate Cycling


Analytical, diagnostic and therapeutic context of Substrate Cycling


  1. The use of 6-labeled glucose to assess futile cycling in Escherichia coli. Chambost, J.P., Fraenkel, D.G. J. Biol. Chem. (1980) [Pubmed]
  2. The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin. Mello, J.A., Acharya, S., Fishel, R., Essigmann, J.M. Chem. Biol. (1996) [Pubmed]
  3. The mode of action of metronidazole in Helicobacter pylori: futile cycling or reduction? Jorgensen, M.A., Manos, J., Mendz, G.L., Hazell, S.L. J. Antimicrob. Chemother. (1998) [Pubmed]
  4. Novel phosphoenolpyruvate-dependent futile cycle in Streptococcus lactis: 2-deoxy-D-glucose uncouples energy production from growth. Thompson, J., Chassy, B.M. J. Bacteriol. (1982) [Pubmed]
  5. Regulation of proline utilization in Salmonella typhimurium: how do cells avoid a futile cycle? Ekena, K., Maloy, S. Mol. Gen. Genet. (1990) [Pubmed]
  6. Effect of severe burn injury on substrate cycling by glucose and fatty acids. Wolfe, R.R., Herndon, D.N., Jahoor, F., Miyoshi, H., Wolfe, M. N. Engl. J. Med. (1987) [Pubmed]
  7. A futile metabolic cycle activated in adipocytes by antidiabetic agents. Guan, H.P., Li, Y., Jensen, M.V., Newgard, C.B., Steppan, C.M., Lazar, M.A. Nat. Med. (2002) [Pubmed]
  8. NF-AT activation requires suppression of Crm1-dependent export by calcineurin. Zhu, J., McKeon, F. Nature (1999) [Pubmed]
  9. Reexamination of glucose-6-phosphatase activity in the brain in vivo: no evidence for a futile cycle. Nelson, T., Lucignani, G., Atlas, S., Crane, A.M., Dienel, G.A., Sokoloff, L. Science (1985) [Pubmed]
  10. Lipoprotein lipase expression exclusively in liver. A mouse model for metabolism in the neonatal period and during cachexia. Merkel, M., Weinstock, P.H., Chajek-Shaul, T., Radner, H., Yin, B., Breslow, J.L., Goldberg, I.J. J. Clin. Invest. (1998) [Pubmed]
  11. Characterization of inhibitors acting at the synthetase site of Escherichia coli asparagine synthetase B. Boehlein, S.K., Nakatsu, T., Hiratake, J., Thirumoorthy, R., Stewart, J.D., Richards, N.G., Schuster, S.M. Biochemistry (2001) [Pubmed]
  12. Folate, DNA stability and colo-rectal neoplasia. Duthie, S.J., Narayanan, S., Sharp, L., Little, J., Basten, G., Powers, H. The Proceedings of the Nutrition Society. (2004) [Pubmed]
  13. Regulation of the futile cycle of fructose phosphate in sea mussel. Ibarguren, I., Diaz-Enrich, M.J., Cao, J., Fernandez, M., Barcia, R., Villamarin, J.A., Ramos-Martinez, J.I. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2000) [Pubmed]
  14. On the role of proofreading exonuclease in bypass of a 1,2 d(GpG) cisplatin adduct by the herpes simplex virus-1 DNA polymerase. Arana, M.E., Song, L., Tanguy Le Gac, N., Parris, D.S., Villani, G., Boehmer, P.E. DNA Repair (Amst.) (2004) [Pubmed]
  15. Saccharomyces carlsbergensis fdp mutant and futile cycling of fructose 6-phosphate. Bañuelos, M., Fraenkel, D.G. Mol. Cell. Biol. (1982) [Pubmed]
  16. Quantitation of adenosine-5'-triphosphate used for phosphoinositide metabolism in human erythrocytes. Dale, G.L. Blood (1985) [Pubmed]
  17. Investigation of malignant hyperthermia: analysis of skeletal muscle proteins from normal and halothane sensitive pigs by two dimensional gel electrophoresis. Lorkin, P.A., Lehmann, H. J. Med. Genet. (1983) [Pubmed]
  18. Metabolic effects of caffeine in humans: lipid oxidation or futile cycling? Acheson, K.J., Gremaud, G., Meirim, I., Montigon, F., Krebs, Y., Fay, L.B., Gay, L.J., Schneiter, P., Schindler, C., Tappy, L. Am. J. Clin. Nutr. (2004) [Pubmed]
  19. Impact of unusual fatty acid synthesis on futile cycling through beta-oxidation and on gene expression in transgenic plants. Moire, L., Rezzonico, E., Goepfert, S., Poirier, Y. Plant Physiol. (2004) [Pubmed]
  20. An integrated view of the metabolic and genetic basis for obesity. James, W.P., Trayhurn, P. Lancet (1976) [Pubmed]
  21. Free fatty acids activate a vigorous Ca(2+):2H(+) antiport activity in yeast mitochondria. Bradshaw, P.C., Jung, D.W., Pfeiffer, D.R. J. Biol. Chem. (2001) [Pubmed]
  22. Quantitative aspects of glucose and glutamine metabolism by intestinal cells. Newsholme, E.A., Carrié, A.L. Gut (1994) [Pubmed]
  23. Measurement of the rates of acetyl-CoA hydrolysis and synthesis from acetate in rat hepatocytes and the role of these fluxes in substrate cycling. Crabtree, B., Gordon, M.J., Christie, S.L. Biochem. J. (1990) [Pubmed]
  24. Hormonal control of substrate cycling in humans. Miyoshi, H., Shulman, G.I., Peters, E.J., Wolfe, M.H., Elahi, D., Wolfe, R.R. J. Clin. Invest. (1988) [Pubmed]
  25. 13C NMR study of gluconeogenesis from labeled alanine in hepatocytes from euthyroid and hyperthyroid rats. Cohen, S.M., Glynn, P., Shulman, R.G. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  26. Existence and role of substrate cycling between AMP and adenosine in isolated rabbit cardiomyocytes under control conditions and in ATP depletion. Wagner, D.R., Bontemps, F., van den Berghe, G. Circulation (1994) [Pubmed]
  27. Evidence for a substrate cycle between AMP and adenosine in isolated hepatocytes. Bontemps, F., Van den Berghe, G., Hers, H.G. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  28. The biology of mitochondrial uncoupling proteins. Rousset, S., Alves-Guerra, M.C., Mozo, J., Miroux, B., Cassard-Doulcier, A.M., Bouillaud, F., Ricquier, D. Diabetes (2004) [Pubmed]
  29. Characterization of a glucose-repressed pyruvate kinase (Pyk2p) in Saccharomyces cerevisiae that is catalytically insensitive to fructose-1,6-bisphosphate. Boles, E., Schulte, F., Miosga, T., Freidel, K., Schlüter, E., Zimmermann, F.K., Hollenberg, C.P., Heinisch, J.J. J. Bacteriol. (1997) [Pubmed]
  30. Cancer therapy with beta-lapachone. Pardee, A.B., Li, Y.Z., Li, C.J. Current cancer drug targets. (2002) [Pubmed]
  31. Peroxisomal proliferator-activated receptor alpha deficiency diminishes insulin-responsiveness of gluconeogenic/glycolytic/pentose gene expression and substrate cycle flux. Xu, J., Chang, V., Joseph, S.B., Trujillo, C., Bassilian, S., Saad, M.F., Lee, W.N., Kurland, I.J. Endocrinology (2004) [Pubmed]
  32. Glucose exerts opposite effects on mRNA versus protein and activity levels of Pde1, the low-affinity cAMP phosphodiesterase from budding yeast, Saccharomyces cerevisiae. Wera, S., Ma, P., Thevelein, J.M. FEBS Lett. (1997) [Pubmed]
  33. Enzymatic amplification by substrate recycling for alpha-ketoglutarate in conjunction with capillary electrophoresis. Fujima, J.M., Danielson, N.D. Journal of capillary electrophoresis. (2002) [Pubmed]
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