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Gene Review

REV7  -  Rev7p

Saccharomyces cerevisiae S288c

Synonyms: DNA polymerase zeta processivity subunit, Revertibility protein 7, YIL139C
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Disease relevance of REV7


High impact information on REV7

  • Mutagenesis induced by DNA damage in Saccharomyces cerevisiae requires the products of the REV1, REV3 and REV7 genes [2].
  • Here, we disrupted Rev1, Rev3, and Rev7 in the chicken B-lymphocyte line DT40 [1].
  • Polzeta consists of two subunits, one encoded by REV3 (the catalytic subunit) and the other encoded by REV7 [3].
  • In this work, we demonstrate both an in vivo and in vitro physical interaction between the Mec3 and Ddc1 subunits of the 9-1-1 clamp and the Rev7 subunit of the Polzeta TLS polymerase [4].
  • The human homologs of S. cerevisiae REV1, REV3, and REV7 were identified, and it is revealed that the human REV proteins have similar functions to their yeast counterparts, however, a large part of the mechanisms of mutagenesis employing REV proteins are still unclear [5].

Biological context of REV7


Associations of REV7 with chemical compounds

  • Three allelic mutations of a new yeast gene, which we have named REV7, have been isolated by testing 313 methyl methane sulfonate sensitive mutants for UV-induced reversion of a lys2 allele [7].
  • Like rev3 and rev7 mutations, ngm2-1 also has little influence on the reversion of the proline missense allele, cyc1-115 [10].

Physical interactions of REV7

  • Importantly, the polymerase-associated domain (PAD) of Rev1 mediates its binding to Rev7 [11].


  1. Multiple roles of vertebrate REV genes in DNA repair and recombination. Okada, T., Sonoda, E., Yoshimura, M., Kawano, Y., Saya, H., Kohzaki, M., Takeda, S. Mol. Cell. Biol. (2005) [Pubmed]
  2. Deoxycytidyl transferase activity of yeast REV1 protein. Nelson, J.R., Lawrence, C.W., Hinkle, D.C. Nature (1996) [Pubmed]
  3. ATR homolog Mec1 controls association of DNA polymerase zeta-Rev1 complex with regions near a double-strand break. Hirano, Y., Sugimoto, K. Curr. Biol. (2006) [Pubmed]
  4. The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae. Sabbioneda, S., Minesinger, B.K., Giannattasio, M., Plevani, P., Muzi-Falconi, M., Jinks-Robertson, S. J. Biol. Chem. (2005) [Pubmed]
  5. The property of DNA polymerase zeta: REV7 is a putative protein involved in translesion DNA synthesis and cell cycle control. Murakumo, Y. Mutat. Res. (2002) [Pubmed]
  6. Alteration of ultraviolet-induced mutagenesis in yeast through molecular modulation of the REV3 and REV7 gene expression. Rajpal, D.K., Wu, X., Wang, Z. Mutat. Res. (2000) [Pubmed]
  7. REV7, a new gene concerned with UV mutagenesis in yeast. Lawrence, C.W., Das, G., Christensen, R.B. Mol. Gen. Genet. (1985) [Pubmed]
  8. Isolation and genetic characterization of the Neurospora crassa REV1 and REV7 homologs: evidence for involvement in damage-induced mutagenesis. Sakai, W., Wada, Y., Naoi, Y., Ishii, C., Inoue, H. DNA Repair (Amst.) (2003) [Pubmed]
  9. Examining the potential role of DNA polymerases eta and zeta in triplet repeat instability in yeast. Dixon, M.J., Lahue, R.S. DNA Repair (Amst.) (2002) [Pubmed]
  10. The isolation and characterization of ngm2, a mutation that affects nitrosoguanidine mutagenesis in yeast. Nisson, P.E., Lawrence, C.W. Mol. Gen. Genet. (1986) [Pubmed]
  11. Complex formation of yeast Rev1 and Rev7 proteins: a novel role for the polymerase-associated domain. Acharya, N., Haracska, L., Johnson, R.E., Unk, I., Prakash, S., Prakash, L. Mol. Cell. Biol. (2005) [Pubmed]
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