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Gene Review

HIS5  -  histidinol-phosphate transaminase

Saccharomyces cerevisiae S288c

Synonyms: Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase, YIL116W
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Disease relevance of HIS5


High impact information on HIS5

  • The residues involved in the E-box recognition are His5, Glu9 and Arg13, as already reported for bHLH/Zip proteins MAX and USF, and are different from those recognized by bHLH proteins MyoD and E47, although PHO4 is a bHLH protein [3].
  • These vectors carry ADE2 or HIS5 as the selectable marker, enabling direct use in AB1380, the host strain of most publicly available YAC libraries [4].
  • Leaky expression was eliminated using 3-aminotriazole and gene conversion was eliminated by using the Schizosaccharomyces pombe his5+ gene, resulting in a 5- to 10-fold improvement in the efficiency of SGA [5].
  • We have constructed a new telomere truncation vector, pGR8, which incorporates two selectable markers, HIS5 and LYS2 [6].
  • That the DNA fragment contains the yeast HIS5 gene was confirmed by the integration of the cloned plasmid into the his5 region of the yeast chromosome [7].

Chemical compound and disease context of HIS5


Biological context of HIS5


Associations of HIS5 with chemical compounds


Regulatory relationships of HIS5


Other interactions of HIS5


  1. Molecular cloning and characterization of the Schizosaccharomyces pombe his3 gene for use as a selectable marker. Burke, J.D., Gould, K.L. Mol. Gen. Genet. (1994) [Pubmed]
  2. Characterization of a gene involved in histidine biosynthesis in Halobacterium (Haloferax) volcanii: isolation and rapid mapping by transformation of an auxotroph with cosmid DNA. Conover, R.K., Doolittle, W.F. J. Bacteriol. (1990) [Pubmed]
  3. Crystal structure of PHO4 bHLH domain-DNA complex: flanking base recognition. Shimizu, T., Toumoto, A., Ihara, K., Shimizu, M., Kyogoku, Y., Ogawa, N., Oshima, Y., Hakoshima, T. EMBO J. (1997) [Pubmed]
  4. Centromeric and noncentromeric ADE2-selectable fragmentation vectors for yeast artificial chromosomes in AB1380. Heus, J.J., de Winther, M.P., van de Vosse, E., van Ommen, G.J., den Dunnen, J.T. Genome Res. (1997) [Pubmed]
  5. Eliminating gene conversion improves high-throughput genetics in Saccharomyces cerevisiae. Daniel, J.A., Yoo, J., Bettinger, B.T., Amberg, D.C., Burke, D.J. Genetics (2006) [Pubmed]
  6. Recombination trapping: an in-vivo approach to recover cDNAs encoded in YACs. Mazzarella, R., Pilia, G. Gene (1998) [Pubmed]
  7. Cloning of the HIS5 gene of Saccharomyces cerevisiae by yeast transformation. Harashima, S., Sidhu, R.S., Toh-e, A., Oshima, Y. Gene (1981) [Pubmed]
  8. REV7, a new gene concerned with UV mutagenesis in yeast. Lawrence, C.W., Das, G., Christensen, R.B. Mol. Gen. Genet. (1985) [Pubmed]
  9. Structure of the yeast HIS5 gene responsive to general control of amino acid biosynthesis. Nishiwaki, K., Hayashi, N., Irie, S., Chung, D.H., Harashima, S., Oshima, Y. Mol. Gen. Genet. (1987) [Pubmed]
  10. Transformation of Candida oleophila and survival of a transformant on orange fruit under field conditions. Chand-Goyal, T., Eckert, J.W., Droby, S., Glickmann, E., Atkinson, K. Curr. Genet. (1999) [Pubmed]
  11. An improved host-vector system for Candida maltosa using a gene isolated from its genome that complements the his5 mutation of Saccharomyces cerevisiae. Hikiji, T., Ohkuma, M., Takagi, M., Yano, K. Curr. Genet. (1989) [Pubmed]
  12. The OGD1 gene, affecting 2-oxoglutarate dehydrogenase in S. cerevisiae, is closely linked to HIS5 on chromosome IX. Ruttkay-Nedecký, B., Subík, J. Curr. Genet. (1990) [Pubmed]
  13. Increase in gene expression by respiratory-deficient mutation. Kaisho, Y., Yoshimura, K., Nakahama, K. Yeast (1989) [Pubmed]
  14. Mutations causing high basal level transcription that is independent of transcriptional activators but dependent on chromosomal position in Saccharomyces cerevisiae. Harashima, S., Mizuno, T., Mabuchi, H., Yoshimitsu, S., Ramesh, R., Hasebe, M., Tanaka, A., Oshima, Y. Mol. Gen. Genet. (1995) [Pubmed]
  15. UVS112--A gene involved in excision repair of yeast. Kozhina, T., Kozhin, S., Stepanova, V., Yarovoy, B., Donich, V., Fedorova, I., Korolev, V. Yeast (1995) [Pubmed]
  16. Characterization of Schizosaccharomyces pombe his1 and his5 cDNAs. Erickson, F.L., Hannig, E.M. Yeast (1995) [Pubmed]
  17. The S1, S2 and SGA1 ancestral genes for the STA glucoamylase genes all map to chromosome IX in Saccharomyces cerevisiae. Lambrechts, M.G., Pretorius, I.S., Marmur, J., Sollitti, P. Yeast (1995) [Pubmed]
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