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Gene Review

PTP3  -  Ptp3p

Saccharomyces cerevisiae S288c

Synonyms: PTPase 3, Protein-tyrosine phosphatase 3, Tyrosine-protein phosphatase 3, YER075C
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High impact information on PTP3


Biological context of PTP3


Anatomical context of PTP3


Associations of PTP3 with chemical compounds

  • Two genes encoding protein-tyrosine phosphatases, PTP2, and a new phosphatase, PTP3, have been isolated in a genetic selection for negative regulators of an osmotic stress response pathway called HOG, for high osmolarity glycerol, in budding yeast [5].
  • Phosphatase activity is required for suppression since mutation of the catalytic Cys residue in Ptp2 and Ptp3, destroys suppressor function and biochemical activity [5].

Physical interactions of PTP3

  • Catalytically inactive Ptp2 and Ptp3 coprecipitate with Hog1 from yeast extracts [5].

Regulatory relationships of PTP3

  • Thus Ptp2 and Ptp3 likely act in a negative feedback loop to inactivate Hog1 [5].

Other interactions of PTP3

  • Deletion of PTP2 and PTP3 blocks cells at an early stage of sporulation before premeiotic DNA synthesis and induction of meiotic-specific genes [4].
  • Ptp2 is predominantly nuclear whereas Ptp3 is cytoplasmic, suggesting that active Mpk1 is present in the nucleus [2].

Analytical, diagnostic and therapeutic context of PTP3


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