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Gene Review

MPZL1  -  myelin protein zero-like 1

Homo sapiens

Synonyms: FLJ21047, MPZL1b, Myelin protein zero-like protein 1, PZR, PZR1b, ...
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Disease relevance of MPZL1


High impact information on MPZL1

  • Furthermore, c-Src was constitutively associated with PZR and was activated upon treatment of cells with ConA [1].
  • PZR is an immunoglobulin superfamily cell surface protein containing a pair of immunoreceptor tyrosine-based inhibitory motifs [1].
  • Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling [1].
  • Recently, we have isolated a transmembrane protein designated PZR that specifically binds tyrosine phosphatase SHP-2, which has two SH2 domains (Zhao, Z. J., and Zhao, R. (1998) J. Biol. Chem. 273, 29367-29372) [2].
  • By site-specific mutagenesis, we found that the tyrosine 241 and 263 embedded in the consensus immunoreceptor tyrosine-based inhibitory motifs VIYAQL and VVYADI, respectively, accounted for the entire tyrosine phosphorylation of PZR [2].

Biological context of MPZL1


Anatomical context of MPZL1


Physical interactions of MPZL1

  • PZR is an immunoglobulin superfamily protein that specifically binds tyrosine phosphatase SHP-2 through its intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) [3].

Enzymatic interactions of MPZL1

  • In vitro, tyrosine-phosphorylated PZR was efficiently dephosphorylated by the full-length form of SHP-2 but not by its SH2 domain-truncated form [2].

Other interactions of MPZL1


Analytical, diagnostic and therapeutic context of MPZL1


  1. Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling. Zhao, R., Guerrah, A., Tang, H., Zhao, Z.J. J. Biol. Chem. (2002) [Pubmed]
  2. Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs. Zhao, R., Zhao, Z.J. J. Biol. Chem. (2000) [Pubmed]
  3. Identification of a variant form of PZR lacking immunoreceptor tyrosine-based inhibitory motifs. Zhao, R., Zhao, Z.J. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  4. Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2. Zhao, Z.J., Zhao, R. J. Biol. Chem. (1998) [Pubmed]
  5. Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration. Zannettino, A.C., Roubelakis, M., Welldon, K.J., Jackson, D.E., Simmons, P.J., Bendall, L.J., Henniker, A., Harrison, K.L., Niutta, S., Bradstock, K.F., Watt, S.M. Biochem. J. (2003) [Pubmed]
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