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Gene Review

HPIV3gp2  -  phosphoprotein

Human parainfluenza virus 3

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Disease relevance of HPIV3gp2


High impact information on HPIV3gp2

  • Mapping of the domains in P (603 amino acids) involved in the association with NP revealed that NH2-terminal 40 and COOH-terminal 20 amino acids are important for such association [1].
  • The phosphoprotein (P) binding site resides in the N terminus of the L polymerase subunit of sendai virus [5].
  • These studies suggest that like the primary, the alternate phosphorylation of the P protein is also dispensable for virus replication in cell cultures [6].
  • Interestingly, the ability of the multiple site mutant of P (combo mutant has eight serine residues changed to alanine residues) to support efficient virus RNA synthesis suggests that the P protein has a high flexibility at least in its sequence and perhaps also in structure [6].
  • Editing at an alternate site (AAUUGGAAAGGAAAGG), mRNA nucleotides 1121-1136, for accession of a conserved V cistron, which is present in a number of paramyxovirus P genes, was not found to occur in HPIV3 [7].

Chemical compound and disease context of HPIV3gp2


Biological context of HPIV3gp2


Associations of HPIV3gp2 with chemical compounds

  • Labelling of virus with [32P]orthophosphate disclosed one band with an Mr of 52K, corresponding to the phosphoprotein [11].
  • Significantly, the P proteins from both viruses are constitutively and primarily phosphorylated at one serine and the phosphorylation of that serine is dependent on the presence of a proline on its carboxyl side [4].

Analytical, diagnostic and therapeutic context of HPIV3gp2


  1. Interaction between the nucleocapsid protein and the phosphoprotein of human parainfluenza virus 3. Mapping of the interacting domains using a two-hybrid system. Zhao, H., Banerjee, A.K. J. Biol. Chem. (1995) [Pubmed]
  2. Sequence analysis of the respiratory syncytial virus phosphoprotein gene. Satake, M., Elango, N., Venkatesan, S. J. Virol. (1984) [Pubmed]
  3. Characterization of the oligomerization domain of the phosphoprotein of human parainfluenza virus type 3. Choudhary, S.K., Malur, A.G., Huo, Y., De, B.P., Banerjee, A.K. Virology (2002) [Pubmed]
  4. Human parainfluenza virus type 1 phosphoprotein is constitutively phosphorylated at Ser-120 and Ser-184. Byrappa, S., Gupta, K.C. J. Gen. Virol. (1999) [Pubmed]
  5. The phosphoprotein (P) binding site resides in the N terminus of the L polymerase subunit of sendai virus. Holmes, D.E., Moyer, S.A. J. Virol. (2002) [Pubmed]
  6. Functional significance of alternate phosphorylation in Sendai virus P protein. Hu, C., Gupta, K.C. Virology (2000) [Pubmed]
  7. RNA editing in the phosphoprotein gene of the human parainfluenza virus type 3. Galinski, M.S., Troy, R.M., Banerjee, A.K. Virology (1992) [Pubmed]
  8. Human parainfluenza virus type 3 phosphoprotein: identification of serine 333 as the major site for PKC zeta phosphorylation. Huntley, C.C., De, B.P., Murray, N.R., Fields, A.P., Banerjee, A.K. Virology (1995) [Pubmed]
  9. Sequence determination and molecular analysis of two strains of bovine parainfluenza virus type 3 that are attenuated for primates. Bailly, J.E., McAuliffe, J.M., Skiadopoulos, M.H., Collins, P.L., Murphy, B.R. Virus Genes (2000) [Pubmed]
  10. The complete nucleotide sequence of the JS strain of human parainfluenza virus type 3: comparison with the Wash/47885/57 prototype strain. Stokes, A., Tierney, E.L., Murphy, B.R., Hall, S.L. Virus Res. (1992) [Pubmed]
  11. The structural proteins of a porcine paramyxovirus (LPMV). Sundqvist, A., Berg, M., Hernandez-Jauregui, P., Linné, T., Moreno-López, J. J. Gen. Virol. (1990) [Pubmed]
  12. Molecular cloning and sequence analysis of the human parainfluenza 3 virus mRNA encoding the P and C proteins. Galinski, M.S., Mink, M.A., Lambert, D.M., Wechsler, S.L., Pons, M.W. Virology (1986) [Pubmed]
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