Gene Review:
ACVR2A - activin A receptor, type IIA
Homo sapiens
Synonyms:
ACTR-IIA, ACTRII, ACTRIIA, ACVR2, Activin receptor type IIA, ...
- Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers. Jung, B., Doctolero, R.T., Tajima, A., Nguyen, A.K., Keku, T., Sandler, R.S., Carethers, J.M. Gastroenterology (2004)
- Differential expression of activin/inhibin subunit and activin receptor mRNAs in normal and neoplastic ovarian surface epithelium (OSE). Choi, K.C., Kang, S.K., Nathwani, P.S., Cheng, K.W., Auersperg, N., Leung, P.C. Mol. Cell. Endocrinol. (2001)
- Truncating mutations in the ACVR2 gene attenuates activin signaling in prostate cancer cells. Rossi, M.R., Ionov, Y., Bakin, A.V., Cowell, J.K. Cancer Genet. Cytogenet. (2005)
- Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers. Hempen, P.M., Zhang, L., Bansal, R.K., Iacobuzio-Donahue, C.A., Murphy, K.M., Maitra, A., Vogelstein, B., Whitehead, R.H., Markowitz, S.D., Willson, J.K., Yeo, C.J., Hruban, R.H., Kern, S.E. Cancer Res. (2003)
- Molecular phenotype of inflammatory bowel disease-associated neoplasms with microsatellite instability. Schulmann, K., Mori, Y., Croog, V., Yin, J., Olaru, A., Sterian, A., Sato, F., Wang, S., Xu, Y., Deacu, E., Berki, A.T., Hamilton, J.P., Kan, T., Abraham, J.M., Schmiegel, W., Harpaz, N., Meltzer, S.J. Gastroenterology (2005)
- Activin type II receptor restoration in ACVR2-deficient colon cancer cells induces transforming growth factor-beta response pathway genes. Deacu, E., Mori, Y., Sato, F., Yin, J., Olaru, A., Sterian, A., Xu, Y., Wang, S., Schulmann, K., Berki, A., Kan, T., Abraham, J.M., Meltzer, S.J. Cancer Res. (2004)
- No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes. Dupont, S., Hani, E.H., Cras-Méneur, C., De Matos, F., Lobbens, S., Lecoeur, C., Vaxillaire, M., Scharfmann, R., Froguel, P. Diabetes (2001)
- Influence of target gene mutations on survival, stage and histology in sporadic microsatellite unstable colon cancers. Jung, B., Smith, E.J., Doctolero, R.T., Gervaz, P., Alonso, J.C., Miyai, K., Keku, T., Sandler, R.S., Carethers, J.M. Int. J. Cancer (2006)
- Accumulation profile of frameshift mutations during development and progression of colorectal cancer from patients with hereditary nonpolyposis colorectal cancer. Yamaguchi, T., Iijima, T., Mori, T., Takahashi, K., Matsumoto, H., Miyamoto, H., Hishima, T., Miyaki, M. Dis. Colon Rectum (2006)