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Gene Review

LPXN  -  leupaxin

Homo sapiens

Synonyms: LDLP, LDPL, Leupaxin
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Disease relevance of LPXN

  • In 81 patients with coronary atherosclerosis, with different number of affected coronary arteries determined by selective coronarography, the blood plasma levels of low-density (LDLP) and high-density (HDLP) lipoproteins were determined, and their lipid and protein components were analyzed [1].

High impact information on LPXN


Biological context of LPXN

  • In the current study, overexpression of LPXN in murine osteoclasts resulted in both enhanced resorptive activity and cell adhesion, as assessed by in vitro resorption assays [4].
  • Overexpression of leupaxin by transduction into osteoclasts evoked numerous cytoplasmic projections at the leading edge of the cell, resembling a motile phenotype [3].

Anatomical context of LPXN

  • Our data indicate that association of the scaffold protein LPXN with Src adds further complexity to the organization of the podosomal signaling complex in osteoclasts [4].
  • As leupaxin and PYK2 are both preferentially expressed in leukocytes they may therefore form a cell type-specific signaling complex [2].
  • Leupaxin can be detected in monocytes and osteoclasts, both cells of hematopoietic origin [3].

Associations of LPXN with chemical compounds

  • Along with the increasing number of arteries affected the percentage of esterified cholesterol in the HDLP decreased, free cholesterol in the HDLP and esterified cholesterol in the LDLP rose [1].

Physical interactions of LPXN

  • We could also demonstrate for the first time that leupaxin interacts with the androgen receptor in a ligand-dependent manner and serves as a transcriptional activator of this hormone receptor in PCa cells [5].

Other interactions of LPXN

  • In the amino-terminal region of leupaxin there are three short stretches of approximately 13 amino acids that share 70-90% similarity with paxillin LD motifs [2].
  • Leupaxin is expressed in cell types, such as macrophage, that lack FAK [2].
  • After exposure to the pro-inflammatory and osteoclastogenic cytokine TNF-alpha, there was an increase in the level of Src that coimmunoprecipitated with LPXN [4].
  • In an attempt to determine an additional biochemical basis for the observed phenomenon in increased osteoclast activity, a coimmunoprecipitation screen for additional binding partners revealed that Src, a protein tyrosine kinase that is critical to both podosome formation and osteoclast function, was also associated with LPXN [4].


  1. The peculiarities of lipid and protein components of the high- and low-density lipoproteins in patients suffering from coronary atherosclerosis with different number of affected coronary arteries. Gasilin, V.S., Kurdanov, K.h.A., Perova, N.V., Torkhovskaya, T.I., Polessky, V.A., Matveeva, L.S. Cor et vasa. (1981) [Pubmed]
  2. Leupaxin is a novel LIM domain protein that forms a complex with PYK2. Lipsky, B.P., Beals, C.R., Staunton, D.E. J. Biol. Chem. (1998) [Pubmed]
  3. Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast. Gupta, A., Lee, B.S., Khadeer, M.A., Tang, Z., Chellaiah, M., Abu-Amer, Y., Goldknopf, J., Hruska, K.A. J. Bone Miner. Res. (2003) [Pubmed]
  4. Association of leupaxin with Src in osteoclasts. Sahu, S.N., Khadeer, M.A., Robertson, B.W., N????ez, S.M., Bai, G., Gupta, A. Am. J. Physiol., Cell Physiol. (2007) [Pubmed]
  5. Leupaxin, a novel coactivator of the androgen receptor, is expressed in prostate cancer and plays a role in adhesion and invasion of prostate carcinoma cells. Kaulfuss, S., Grzmil, M., Hemmerlein, B., Thelen, P., Schweyer, S., Neesen, J., Bubendorf, L., Glass, A.G., Jarry, H., Auber, B., Burfeind, P. Mol. Endocrinol. (2008) [Pubmed]
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