The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

prpB  -  2-methylisocitrate lyase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0329, JW0323, yahQ
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of prpB


High impact information on prpB


Associations of prpB with chemical compounds


  1. Identification of the 2-methylcitrate pathway involved in the catabolism of propionate in the polyhydroxyalkanoate-producing strain Burkholderia sacchari IPT101(T) and analysis of a mutant accumulating a copolyester with higher 3-hydroxyvalerate content. Brämer, C.O., Silva, L.F., Gomez, J.G., Priefert, H., Steinbüchel, A. Appl. Environ. Microbiol. (2002) [Pubmed]
  2. Crystal structure of 2-methylisocitrate lyase (PrpB) from Escherichia coli and modelling of its ligand bound active centre. Grimm, C., Evers, A., Brock, M., Maerker, C., Klebe, G., Buckel, W., Reuter, K. J. Mol. Biol. (2003) [Pubmed]
  3. A Salmonella-based, propionate-inducible, expression system for Salmonella enterica. Lee, S.K., Keasling, J.D. Gene (2006) [Pubmed]
  4. Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis. Gould, T.A., van de Langemheen, H., Muñoz-Elías, E.J., McKinney, J.D., Sacchettini, J.C. Mol. Microbiol. (2006) [Pubmed]
  5. Crystal structures of 2-methylisocitrate lyase in complex with product and with isocitrate inhibitor provide insight into lyase substrate specificity, catalysis and evolution. Liu, S., Lu, Z., Han, Y., Melamud, E., Dunaway-Mariano, D., Herzberg, O. Biochemistry (2005) [Pubmed]
  6. Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle. Horswill, A.R., Escalante-Semerena, J.C. J. Bacteriol. (1999) [Pubmed]
  7. Propionate catabolism in Salmonella typhimurium LT2: two divergently transcribed units comprise the prp locus at 8.5 centisomes, prpR encodes a member of the sigma-54 family of activators, and the prpBCDE genes constitute an operon. Horswill, A.R., Escalante-Semerena, J.C. J. Bacteriol. (1997) [Pubmed]
  8. 2-Methylisocitrate lyases from the bacterium Escherichia coli and the filamentous fungus Aspergillus nidulans: characterization and comparison of both enzymes. Brock, M., Darley, D., Textor, S., Buckel, W. Eur. J. Biochem. (2001) [Pubmed]
WikiGenes - Universities