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Gene Review

malT  -  mal regulon transcriptional activator

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3405, JW3381, malA
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Disease relevance of malT


High impact information on malT

  • Secretion genes located 5' to pulA were transcribed in the opposite orientation to pulA under the control of the previously identified, malT-regulated malX promoter [5].
  • These mutants are also altered in positive control at the lac and malT promoters, where CAP binds to sites further upstream from the transcription start site [6].
  • Expression of the Escherichia coli maltose regulon is controlled by MalT, a transcriptional activator (Mr = 102,288) encoded by the malT gene [7].
  • The mlc gene encodes a transcriptional regulator that has been shown to affect the expression of manXYZ and malT. ptsG mRNA levels are lower in the mlc strain grown on glucose than in the same strain grown on glycerol [8].
  • The malA region of Escherichia coli contains one of the three maltose operons, namely malPQ, and the positive regulatory gene, malT [9].

Chemical compound and disease context of malT

  • The pores of the C. crescentus porins are slightly larger than those of E. coli K-12, since maltotetraose supported growth of the C. crescentus malA mutant but failed to support growth of the E. coli lamB mutant [10].
  • Permeation of maltose and maltotriose through the outer membrane of the C. crescentus malA mutant was slower than permeation through the outer membrane of an E. coli lamB mutant, which suggests a low porin activity in C. crescentus [10].

Biological context of malT

  • A DNA sequence containing the control sites for gene malT and for the malPQ operon [11].
  • The order of 802 base pairs was established in a DNA segment containing the promoter for malPQ which is one of the three maltose operons, and the promoter for malT, the positive regulator gene of the maltose regulon [11].
  • By deleting in vitro the 3'-end of the gene or constructing malT-lacZ gene fusions, it was found that the integrity of the C-terminus of MalT is indispensable for the activity of the protein [12].
  • However this requirement is lost when the expression of malT, positive regulator gene of the maltose regulon, is rendered independent of CAP by a mutation in the malT promoter [13].
  • A restriction map of the HindIII-EcoRI fragment was established, and it was correlated with the genetic map of the malA region (i) by mapping deletions which had been generated in vitro on the plasmid and (ii) by locating on the restriction map a DNA insertion of known genetic position [2].

Associations of malT with chemical compounds


Other interactions of malT


  1. Comparison of the malA regions of Escherichia coli and Klebsiella pneumoniae. Bloch, M.A., Raibaud, O. J. Bacteriol. (1986) [Pubmed]
  2. Restriction map of the Escherichia coli malA region and identification of the malT product. Raibaud, O., Schwartz, M. J. Bacteriol. (1980) [Pubmed]
  3. Extensive segments of the Escherichia coli K12 chromosome in Proteus mirabilis diploids. Wohlhieter, J.A., Gemski, P., Baron, L.S. Mol. Gen. Genet. (1975) [Pubmed]
  4. Isolation and mapping of glutathione reductase-negative mutants of Escherichia coli K12. Davis, N.K., Greer, S., Jones-Mortimer, M.C., Perham, R.N. J. Gen. Microbiol. (1982) [Pubmed]
  5. Cloning and expression in Escherichia coli of the Klebsiella pneumoniae genes for production, surface localization and secretion of the lipoprotein pullulanase. d'Enfert, C., Ryter, A., Pugsley, A.P. EMBO J. (1987) [Pubmed]
  6. Mutants of the catabolite activator protein of Escherichia coli that are specifically deficient in the gene-activation function. Irwin, N., Ptashne, M. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  7. Purification and properties of the MalT protein, the transcription activator of the Escherichia coli maltose regulon. Richet, E., Raibaud, O. J. Biol. Chem. (1987) [Pubmed]
  8. Expression of ptsG, the gene for the major glucose PTS transporter in Escherichia coli, is repressed by Mlc and induced by growth on glucose. Plumbridge, J. Mol. Microbiol. (1998) [Pubmed]
  9. Use of deletions created in vitro to map transcriptional regulatory signals in the malA region of Escherichia coli. Raibaud, O., Débarbouillé, M., Schwartz, M. J. Mol. Biol. (1983) [Pubmed]
  10. ExbBD-dependent transport of maltodextrins through the novel MalA protein across the outer membrane of Caulobacter crescentus. Neugebauer, H., Herrmann, C., Kammer, W., Schwarz, G., Nordheim, A., Braun, V. J. Bacteriol. (2005) [Pubmed]
  11. A DNA sequence containing the control sites for gene malT and for the malPQ operon. Debarbouille, M., Cossart, P., Raibaud, O. Mol. Gen. Genet. (1982) [Pubmed]
  12. The nucleotide sequence of the malT gene encoding the positive regulator of the Escherichia coli maltose regulon. Cole, S.T., Raibaud, O. Gene (1986) [Pubmed]
  13. Indirect effects of the 3'-5' cyclic adenosine monophosphate binding protein (CAP) on the transcription of the malPQ operon in Escherichia coli. Gutierrez, C., Chapon, C., Schwartz, M. Biochimie (1985) [Pubmed]
  14. Reconstitution of maltose transport in malB and malA mutants of Escherichia coli. Brass, J.M. Ann. Microbiol. (Paris) (1982) [Pubmed]
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