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Gene Review

recG  -  ATP-dependent DNA helicase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3642, JW3627, radC, spoV
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Disease relevance of recG


High impact information on recG

  • The product of the recG gene of Escherichia coli is needed for normal recombination and DNA repair in E. coli and has been shown to help process Holliday junction intermediates to mature products by catalysing branch migration [3].
  • Mutations in priA and recG increased or decreased deletion rates, but repeats were still greatly stabilized in the chromosome [4].
  • The hbs4755 mutation did not modify the sensitivity of recH and addAB cells to the DNA-damaging agents methylmethane sulphonate (MMS) or 4-nitroquinoline-1-oxide (4NQO), and it only marginally affected recF and recG cells [5].
  • A plasmid carrying the intact mmsA coding region was shown to restore UV resistance to E. coli recG mutant strains [6].
  • The fact that in E. coli recG phenotypes are not constant in other species indicates the diverse roles for conserved recombination genes in prokaryotic evolution [2].

Biological context of recG


Other interactions of recG

  • In contrast, frequencies of RecET-mediated illegitimate recombination were not affected by ruvAB, ruvC, recG, and recN mutations [10].
  • A radA mutation was strongly synergistic with the recG Holliday junction helicase mutation, producing profound sensitivity to all DNA-damaging agents tested [11].
  • (CAG)n.(CTG)n deletion rates were decreased, relative to the rates in wild type cells, in strains containing mutations in priA, recG, ruvAB, and recO [12].
  • A mutation in the sfiA gene, which encodes and SOS-inducible inhibitor of septum formation, partially suppressed filamentation of recG mutant cells, but did not prevent the formation of anucleate cells [13].


  1. The nucleotide sequence of recG, the distal spo operon gene in Escherichia coli K-12. Kalman, M., Murphy, H., Cashel, M. Gene (1992) [Pubmed]
  2. Effect of host species on recG phenotypes in Helicobacter pylori and Escherichia coli. Kang, J., Tavakoli, D., Tschumi, A., Aras, R.A., Blaser, M.J. J. Bacteriol. (2004) [Pubmed]
  3. Branch migration of Holliday junctions: identification of RecG protein as a junction specific DNA helicase. Whitby, M.C., Vincent, S.D., Lloyd, R.G. EMBO J. (1994) [Pubmed]
  4. (CAG){middle dot}(CTG) Repeats Associated with Neurodegenerative Diseases Are Stable in the Escherichia coli Chromosome. Kim, S.H., Pytlos, M.J., Rosche, W.A., Sinden, R.R. J. Biol. Chem. (2006) [Pubmed]
  5. The Bacillus subtilis chromatin-associated protein Hbsu is involved in DNA repair and recombination. Fernández, S., Rojo, F., Alonso, J.C. Mol. Microbiol. (1997) [Pubmed]
  6. The mmsA locus of Streptococcus pneumoniae encodes a RecG-like protein involved in DNA repair and in three-strand recombination. Martin, B., Sharples, G.J., Humbert, O., Lloyd, R.G., Claverys, J.P. Mol. Microbiol. (1996) [Pubmed]
  7. Modulation of recombination and DNA repair by the RecG and PriA helicases of Escherichia coli K-12. Al-Deib, A.A., Mahdi, A.A., Lloyd, R.G. J. Bacteriol. (1996) [Pubmed]
  8. Recombination-promoting activity of the bacteriophage lambda Rap protein in Escherichia coli K-12. Poteete, A.R., Fenton, A.C., Wang, H.R. J. Bacteriol. (2002) [Pubmed]
  9. A RecG-independent nonconservative branch migration mechanism in Escherichia coli recombination. Friedman-Ohana, R., Karunker, I., Cohen, A. J. Bacteriol. (1999) [Pubmed]
  10. The role of UvrD in RecET-mediated illegitimate recombination in Escherichia coli. Shiraishi, K., Imai, Y., Yoshizaki, S., Tadaki, T., Ogata, Y., Ikeda, H. Genes Genet. Syst. (2006) [Pubmed]
  11. Role for radA/sms in recombination intermediate processing in Escherichia coli. Beam, C.E., Saveson, C.J., Lovett, S.T. J. Bacteriol. (2002) [Pubmed]
  12. Replication restart: a pathway for (CTG).(CAG) repeat deletion in Escherichia coli. Kim, S.H., Pytlos, M.J., Sinden, R.R. Mutat. Res. (2006) [Pubmed]
  13. Roles of the recG gene product of Escherichia coli in recombination repair: effects of the delta recG mutation on cell division and chromosome partition. Ishioka, K., Iwasaki, H., Shinagawa, H. Genes Genet. Syst. (1997) [Pubmed]
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