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icdA  -  isocitrate dehydrogenase

Escherichia coli O157:H7 str. EDL933

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Disease relevance of icdA

  • Mutagenesis target sites were based on crystal structures of metal-isocitrate complexes of Escherichia coli and pig mitochondrial NADP-IDH and sequence alignments [1].
  • Lambdoid phage 21 inserts within the isocitrate dehydrogenase gene and introduces an alternative 165 bp 3' end for that gene [2].

High impact information on icdA


Biological context of icdA

  • Moreover, the main metabolic pathways and carbon flow operating during cell biotransformation was that controlled by the ICDH/ICL ratio, which decreased from 8.0 to 2.5, and the phosphotransferase/ACS ratio, which increased from 2.1 to 5.2, after a NaCl pulse fivefold the steady-state level [6].

Analytical, diagnostic and therapeutic context of icdA

  • Two structurally different monomeric and dimeric types of isocitrate dehydrogenase (IDH; EC isozymes were confirmed to exist in a psychrophilic bacterium, Colwellia psychrerythraea, by Western blot analysis and the genes encoding them were cloned and sequenced [7].
  • Thr(373), Lys(374), Asp(375), and Lys(260) were chosen as site-directed mutagenesis targets within porcine NADP-dependent isocitrate dehydrogenase based on structurally corrected sequence alignment among prokaryotic and eukaryotic NADP-isocitrate dehydrogenases [4].


  1. Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. Soundar, S., O'hagan, M., Fomulu, K.S., Colman, R.F. J. Biol. Chem. (2006) [Pubmed]
  2. Lambdoid phages as elements of bacterial genomes (integrase/phage21/Escherichia coli K-12/icd gene). Campbell, A., Schneider, S.J., Song, B. Genetica (1992) [Pubmed]
  3. Role of phosphoenolpyruvate in the NADP-isocitrate dehydrogenase and isocitrate lyase reaction in Escherichia coli. Ogawa, T., Murakami, K., Mori, H., Ishii, N., Tomita, M., Yoshin, M. J. Bacteriol. (2007) [Pubmed]
  4. Thr373, Asp375, and Lys260 are in the coenzyme site of porcine NADP-dependent isocitrate dehydrogenase. Lee, P., Colman, R.F. Arch. Biochem. Biophys. (2006) [Pubmed]
  5. Microbial source tracking by DNA sequence analysis of the Escherichia coli malate dehydrogenase gene. Ivanetich, K.M., Hsu, P.H., Wunderlich, K.M., Messenger, E., Walkup, W.G., Scott, T.M., Lukasik, J., Davis, J. J. Microbiol. Methods (2006) [Pubmed]
  6. Salt stress effects on the central and carnitine metabolisms of Escherichia coli. Cánovas, M., Bernal, V., Sevilla, A., Iborra, J.L. Biotechnol. Bioeng. (2007) [Pubmed]
  7. Two isocitrate dehydrogenases from a psychrophilic bacterium, Colwellia psychrerythraea. Maki, S., Yoneta, M., Takada, Y. Extremophiles (2006) [Pubmed]
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