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Gene Review

ZFYVE16  -  zinc finger, FYVE domain containing 16

Homo sapiens

Synonyms: Endofin, Endosome-associated FYVE domain protein, KIAA0305, PPP1R69, Zinc finger FYVE domain-containing protein 16
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High impact information on ZFYVE16


Biological context of ZFYVE16


Anatomical context of ZFYVE16

  • The association of endofin with endosomes is mediated by its FYVE domain because deletion mutants lacking the central FYVE finger motif are distributed in the cytoplasm [3].

Associations of ZFYVE16 with chemical compounds


Co-localisations of ZFYVE16

  • We also show that endofin co-localizes with SARA but that they are not associated in a common complex because they failed to co-immunoprecipitate in co-expressing cells [3].

Other interactions of ZFYVE16

  • Taken together, this report provides evidence to suggest that endofin and the highly related SARA are endosomal proteins with potential roles in regulating membrane traffic [3].
  • Endofin also does not associate with Smad2 nor behave like SARA in affecting transforming growth factor-beta signaling [3].
  • Endofin recruits clathrin to early endosomes via TOM1 [5].
  • Taken together, our results suggest that endofin plays an important role in both positive and negative feedback regulation of the BMP signaling pathway [4].

Analytical, diagnostic and therapeutic context of ZFYVE16


  1. Endofin, a FYVE Domain Protein, Interacts with Smad4 and Facilitates Transforming Growth Factor-beta Signaling. Chen, Y.G., Wang, Z., Ma, J., Zhang, L., Lu, Z. J. Biol. Chem. (2007) [Pubmed]
  2. Endofin recruits TOM1 to endosomes. Seet, L.F., Liu, N., Hanson, B.J., Hong, W. J. Biol. Chem. (2004) [Pubmed]
  3. Endofin, an endosomal FYVE domain protein. Seet, L.F., Hong, W. J. Biol. Chem. (2001) [Pubmed]
  4. Endofin acts as a Smad anchor for receptor activation in BMP signaling. Shi, W., Chang, C., Nie, S., Xie, S., Wan, M., Cao, X. J. Cell. Sci. (2007) [Pubmed]
  5. Endofin recruits clathrin to early endosomes via TOM1. Seet, L.F., Hong, W. J. Cell. Sci. (2005) [Pubmed]
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