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Gene Review

HNRNPDL  -  heterogeneous nuclear ribonucleoprotein D...

Homo sapiens

Synonyms: AU-rich element RNA-binding factor, HNRNP, HNRPDL, Heterogeneous nuclear ribonucleoprotein D-like, JKT41-binding protein, ...
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High impact information on HNRPDL

  • An antiserum raised to the conceptual reading frame of HNRNP G-T showed that it encodes a protein that is highly expressed in germ cells and in particular in the nuclei of meiotic spermatocytes [1].
  • However, unlike many retroposon-derived genes, HNRNP G-T is not a pseudogene [1].
  • We have identified a new member of this gene family, HNRNP G-T, and have mapped it as a single-copy gene on chromosome 11 [1].
  • In differentiated myotubes, heterogeneous nuclear ribonucleoprotein D-like protein/JKTBP1 bound to the CATR motif exclusive of YY-1 and interacted with ZBP-89 in attenuating repressor activity, leading to transcription activation [2].
  • We discuss a role of JKTBP in mRNA nuclear export [3].

Biological context of HNRPDL

  • Isolation and characterization of the genomic DNA showed that the gene (HNRPDL) had nine exons and had two separate transcription start sites for the two transcripts [4].
  • JKTBP proteins are related to a family of heterogeneous nuclear ribonucleoproteins (hnRNPs) that function in mRNA biogenesis and mRNA metabolism [3].
  • For examination of RNA binding specificity of JKTBP, we enriched high binding sites from pools of 20 nt random sequence-containing RNAs by a selection/amplification method [5].
  • These results indicate that JKTBP is a sequence-specific RNA binding protein differing from the related heterogeneous nuclear ribonucleoproteins A1 and D [5].
  • Nevertheless, the R100H mutation detected suggests that in some men mutations in the HNRNP G-T gene can cause impaired spermatogenesis [6].

Anatomical context of HNRPDL


Physical interactions of HNRPDL

  • JKTBP proteins consisting of two canonical RNA binding domains (RBDs) and a glycine-rich carboxyl domain are nucleocytoplasmic shuttling proteins [5].

Other interactions of HNRPDL


  1. An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene. Elliott, D.J., Venables, J.P., Newton, C.S., Lawson, D., Boyle, S., Eperon, I.C., Cooke, H.J. Hum. Mol. Genet. (2000) [Pubmed]
  2. Regulation of murine cytochrome c oxidase Vb gene expression during myogenesis: YY-1 and heterogeneous nuclear ribonucleoprotein D-like protein (JKTBP1) reciprocally regulate transcription activity by physical interaction with the BERF-1/ZBP-89 factor. Boopathi, E., Lenka, N., Prabu, S.K., Fang, J.K., Wilkinson, F., Atchison, M., Giallongo, A., Avadhani, N.G. J. Biol. Chem. (2004) [Pubmed]
  3. Identification of the nucleocytoplasmic shuttling sequence of heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its interaction with mRNA. Kawamura, H., Tomozoe, Y., Akagi, T., Kamei, D., Ochiai, M., Yamada, M. J. Biol. Chem. (2002) [Pubmed]
  4. Two forms of expression and genomic structure of the human heterogeneous nuclear ribonucleoprotein D-like JKTBP gene (HNRPDL). Kamei, D., Tsuchiya, N., Yamazaki, M., Meguro, H., Yamada, M. Gene (1999) [Pubmed]
  5. Interactions of heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its domains with high-affinity binding sites. Kamei, D., Yamada, M. Gene (2002) [Pubmed]
  6. Heterogeneous nuclear ribonucleoprotein G-T (HNRNP G-T) mutations in men with impaired spermatogenesis. Westerveld, G.H., Gianotten, J., Leschot, N.J., van der Veen, F., Repping, S., Lombardi, M.P. Mol. Hum. Reprod. (2004) [Pubmed]
  7. Molecular cloning of the cDNA encoding A + U-rich element RNA binding factor. Doi, A., Shiosaka, T., Takaoka, Y., Yanagisawa, K., Fujita, S. Biochim. Biophys. Acta (1998) [Pubmed]
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