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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Periodontitis, Juvenile

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Disease relevance of Periodontitis, Juvenile

  • Sera from patients with localized juvenile periodontitis (LJP) often contain markedly elevated levels of immunoglobulin G2 (IgG2) antibodies reactive to cell envelope constituents of Actinobacillus actinomycetemcomitans [1].
  • Antigen bands in the OMA were identified using 7 sera obtained from 3 adult periodontitis (AP) and 4 localized juvenile periodontitis (LJP) patients that were documented with elevated A. actinomycetemcomitans antibody and infection [2].

High impact information on Periodontitis, Juvenile


Chemical compound and disease context of Periodontitis, Juvenile


Anatomical context of Periodontitis, Juvenile

  • BACKGROUND: Neutrophils from patients with localized juvenile periodontitis (LJP) exhibit decreased binding and responsiveness to various chemotactic agents, including N-formyl-1-methionyl-1-leucyl-1-phenylalanine (FMLP) [13].
  • This study was designed to define the relative distribution of lymphocytes (Lc) and plasma cells (Pc) and the nature of cell-associated immunoglobulins (Ig), IgG, IgM, IgA, IgD, and IgE, and IgG subclasses IgG1, IgG2, IgG3 and IgG4, in gingiva from patients with periodontosis (juvenile periodontitis) [14].

Gene context of Periodontitis, Juvenile

  • We therefore examined the levels of MMP-1, -3, -8 and -9, and their endogenous inhibitor, tissue inhibitor of matrix metalloproteinases (TIMP-1), in GCF and saliva of patients with adult periodontitis (AP) and localized juvenile periodontitis (LJP) [15].
  • OBJECTIVE: The aim of this study was to examine the longitudinal association of selected non-immune anti-microbial host factors (peroxidases, lysozyme and lactoferrin) to the localized juvenile periodontitis (LJP) disease status [16].
  • The distribution of HLA-A and -B antigens in patients and their families with periodontosis [17].
  • The observations made in this material indicate that what has been diagnosed as periodontosis, in fact is a highly destructive juvenile periodontitis which should be so named [18].
  • The NADPH oxidase activity of 40 diabetic patients with periodontosis who were on metabolic control was evaluated and compared with that in 40 healthy subjects [19].

Analytical, diagnostic and therapeutic context of Periodontitis, Juvenile

  • The present investigation was performed to study the effect on localized juvenile periodontitis (LJP) of a treatment program which included tetracycline administration, surgical elimination of inflamed tissues, scaling and root planing, and careful plaque control during healing [20].


  1. Immunoglobulin G2 antibodies promote neutrophil killing of Actinobacillus actinomycetemcomitans. Wilson, M.E., Bronson, P.M., Hamilton, R.G. Infect. Immun. (1995) [Pubmed]
  2. Antigenic diversity in the periodontopathogen, Actinobacillus actinomycetemcomitans. Ebersole, J.L., Hall, E.E., Steffen, M.J. Immunol. Invest. (1996) [Pubmed]
  3. Lipoxin A(4) analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: a role for cyclooxygenase-2 and lipoxins in periodontal disease. Pouliot, M., Clish, C.B., Petasis, N.A., Van Dyke, T.E., Serhan, C.N. Biochemistry (2000) [Pubmed]
  4. Regulation of immunoglobulin G2 production by prostaglandin E(2) and platelet-activating factor. Ishihara, Y., Zhang, J.B., Quinn, S.M., Schenkein, H.A., Best, A.M., Barbour, S.E., Tew, J.G. Infect. Immun. (2000) [Pubmed]
  5. Evidence that the serotype b antigenic determinant of Actinobacillus actinomycetemcomitans Y4 resides in the polysaccharide moiety of lipopolysaccharide. Wilson, M.E., Schifferle, R.E. Infect. Immun. (1991) [Pubmed]
  6. Contrasting evolution of the human leukocyte N-formylpeptide receptor subtypes FPR and FPRL1R. Sahagun-Ruiz, A., Colla, J.S., Juhn, J., Gao, J.L., Murphy, P.M., McDermott, D.H. Genes Immun. (2001) [Pubmed]
  7. Evidence for the role of highly leukotoxic Actinobacillus actinomycetemcomitans in the pathogenesis of localized juvenile and other forms of early-onset periodontitis. Haraszthy, V.I., Hariharan, G., Tinoco, E.M., Cortelli, J.R., Lally, E.T., Davis, E., Zambon, J.J. J. Periodontol. (2000) [Pubmed]
  8. Immunoglobulin G subclass response of localized juvenile periodontitis patients to Actinobacillus actinomycetemcomitans Y4 lipopolysaccharide. Wilson, M.E., Hamilton, R.G. Infect. Immun. (1992) [Pubmed]
  9. Resolution of early lesions of juvenile periodontitis with tetracycline therapy alone: long-term observations of 4 cases. Novak, M.J., Stamatelakys, C., Adair, S.M. J. Periodontol. (1991) [Pubmed]
  10. Metronidazole in the treatment of localized juvenile periodontitis. Saxén, L., Asikainen, S. Journal of clinical periodontology. (1993) [Pubmed]
  11. The effect of treatment on Actinobacillus actinomycetemcomitans in localized juvenile periodontitis. Mandell, R.L., Tripodi, L.S., Savitt, E., Goodson, J.M., Socransky, S.S. J. Periodontol. (1986) [Pubmed]
  12. [Oxyproline metabolism in periodontosis]. Kulikova, V.S., Nikitina, T.V. Stomatologiia. (1975) [Pubmed]
  13. Single nucleotide polymorphisms of the N-formyl peptide receptor in localized juvenile periodontitis. Gwinn, M.R., Sharma, A., De Nardin, E. J. Periodontol. (1999) [Pubmed]
  14. Immunologic study of human periodontosis (juvenile periodontitis). Waldrop, T.C., Mackler, B.F., Schur, P., Killoy, W. J. Periodontol. (1981) [Pubmed]
  15. Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients. Ingman, T., Tervahartiala, T., Ding, Y., Tschesche, H., Haerian, A., Kinane, D.F., Konttinen, Y.T., Sorsa, T. Journal of clinical periodontology. (1996) [Pubmed]
  16. Peroxidases, lactoferrin and lysozyme in peripheral blood neutrophils, gingival crevicular fluid and whole saliva of patients with localized juvenile periodontitis. Suomalainen, K., Saxén, L., Vilja, P., Tenovuo, J. Oral diseases. (1996) [Pubmed]
  17. The distribution of HLA-A and -B antigens in patients and their families with periodontosis. Cullinan, M.P., Sachs, J., Wolf, E., Seymour, G.J. J. Periodont. Res. (1980) [Pubmed]
  18. Subgingival plaque and loss of attachment in periodontosis as evaluated on extracted teeth. Waerhaug, J. J. Periodontol. (1977) [Pubmed]
  19. Respiratory burst of neutrophils in diabetic patients with periodontal disease. De Toni, S., Piva, E., Lapolla, A., Fontana, G., Fedele, D., Plebani, M. Ann. N. Y. Acad. Sci. (1997) [Pubmed]
  20. Treatment of localized juvenile periodontitis. Results after 5 years. Lindhe, J., Liljenberg, B. Journal of clinical periodontology. (1984) [Pubmed]
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