Disease relevance of Instillation, Drug

• Starting on day 3 post-infection, animals were treated daily, for 3 consecutive days, with saline, empty liposomes, free polymyxin B, or liposomal polymyxin B (2mg polymyxin B/kg body weight) by intratracheal instillation; animals were killed 24hr after the third drug instillation [1].
• Olopatadine was significantly (p < 0.001) more effective than ketorolac in reducing hyperemia and ocular itching at all time points and was also significantly (p < 0.05) more comfortable than ketorolac as reported by subjects immediately following drug instillation [2].

High impact information on Instillation, Drug

• At various time intervals (0.25 to 16 h) after drug instillations, the remaining tobramycin was evaluated in blood, lungs, and kidneys by a microbiological assay [3].
• The most common adverse events associated with unoprostone were burning/stinging, burning/stinging directly upon drug instillation, ocular itching, and conjunctival hyperaemia [4].
• After termination of the drug instillation, corneal sensitivity returned to baseline significantly slower (P < .01) in participants receiving diclofenac than in those receiving ketorolac [5].
• A significantly lower incidence of burning and stinging after drug instillation was noted with dipivefrin therapy [6].
• The betaxolol concentration in aqueous humour was 731 ng m-1 in group la, 2.4 h after drug instillation [7].

Anatomical context of Instillation, Drug

• The blood flow of iris, ciliary body-iris root, and choroid was increased by rescinnamine for 344%, 234%, and 199%, respectively; by apocynin for 355%, 152%, and 414%, respectively; and by hesperetin for 265%, 136%, and 204%, respectively, at 120 minutes after drug instillation [8].

Associations of Instillation, Drug with chemical compounds

• About 18 h after drug instillation the aqueous humour concentration of timolol was 105.5 +/- 60.9 ng/ml [9].
• STTs were performed immediately before instillation of tropicamide and then at 1, 4, 8 and 24 h post drug instillation [10].
• In the drug instillation test, pupillary responses to both neosynephrine and pilocarpine were decreased, indicating damage both to the dilator and sphincter muscles [11].
• Twenty-seven minutes after drug instillation subjects were challenged with allergen [2].
• However, with an air flush following the saline flush after the drug instillation, there was no difference in the amount of epinephrine delivered between the two methods [12].

Gene context of Instillation, Drug

• The glucagon eyedrops raised the blood glucose efficiently in a dose-dependent manner and peaked at 30 min after drug instillation [13].

References