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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Instillation, Drug

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Disease relevance of Instillation, Drug

  • Starting on day 3 post-infection, animals were treated daily, for 3 consecutive days, with saline, empty liposomes, free polymyxin B, or liposomal polymyxin B (2mg polymyxin B/kg body weight) by intratracheal instillation; animals were killed 24hr after the third drug instillation [1].
  • Olopatadine was significantly (p < 0.001) more effective than ketorolac in reducing hyperemia and ocular itching at all time points and was also significantly (p < 0.05) more comfortable than ketorolac as reported by subjects immediately following drug instillation [2].

High impact information on Instillation, Drug


Anatomical context of Instillation, Drug

  • The blood flow of iris, ciliary body-iris root, and choroid was increased by rescinnamine for 344%, 234%, and 199%, respectively; by apocynin for 355%, 152%, and 414%, respectively; and by hesperetin for 265%, 136%, and 204%, respectively, at 120 minutes after drug instillation [8].

Associations of Instillation, Drug with chemical compounds


Gene context of Instillation, Drug


  1. Enhanced activity of liposomal polymyxin B against Pseudomonas aeruginosa in a rat model of lung infection. Omri, A., Suntres, Z.E., Shek, P.N. Biochem. Pharmacol. (2002) [Pubmed]
  2. Comparative evaluation of olopatadine ophthalmic solution (0.1%) versus ketorolac ophthalmic solution (0.5%) using the provocative antigen challenge model. Deschenes, J., Discepola, M., Abelson, M. Acta ophthalmologica Scandinavica. Supplement. (1999) [Pubmed]
  3. Pulmonary retention of free and liposome-encapsulated tobramycin after intratracheal administration in uninfected rats and rats infected with Pseudomonas aeruginosa. Omri, A., Beaulac, C., Bouhajib, M., Montplaisir, S., Sharkawi, M., Lagacé, J. Antimicrob. Agents Chemother. (1994) [Pubmed]
  4. Safety of unoprostone isopropyl as mono- or adjunctive therapy in patients with primary open-angle glaucoma or ocular hypertension. de Arruda Mello, P.A., Yannoulis, N.C., Haque, R.M. Drug safety : an international journal of medical toxicology and drug experience. (2002) [Pubmed]
  5. Corneal sensitivity and burning sensation. Comparing topical ketorolac and diclofenac. Seitz, B., Sorken, K., LaBree, L.D., Garbus, J.J., McDonnell, P.J. Arch. Ophthalmol. (1996) [Pubmed]
  6. Dipivefrin and epinephrine treatment of elevated intraocular pressure: a comparative study. Kass, M.A., Mandell, A.I., Goldberg, I., Paine, J.M., Becker, B. Arch. Ophthalmol. (1979) [Pubmed]
  7. Aqueous humour concentration and the intraocular pressure-lowering effect of topical betaxolol before cataract surgery. Vainio-Jylhä, E., Vuori, M.L., Kaila, T., Huupponen, R. Eur. J. Clin. Pharmacol. (1998) [Pubmed]
  8. Increase of ocular blood flow by some phytogenic compounds. Liu, S.X., Chiang, C.H., Yao, Q.S., Chiou, G.C. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (1996) [Pubmed]
  9. Absorption of ocular timolol: drug concentrations and beta-receptor binding activity in the aqueous humour of the treated and contralateral eye. Saari, K.M., Ali-Melkkilä, T., Vuori, M.L., Kaila, T., Iisalo, E. Acta ophthalmologica. (1993) [Pubmed]
  10. Effect of topical tropicamide on tear production as measured by Schirmer's tear test in normal dogs and cats. Margadant, D.L., Kirkby, K., Andrew, S.E., Gelatt, K.N. Veterinary ophthalmology. (2003) [Pubmed]
  11. The effects of phaco-emulsification-aspiration and intra-ocular lens implantation on the pupil: pupillographic and pharmacologic study. Komatsu, M., Oono, S., Shimizu, K. Ophthalmologica (1997) [Pubmed]
  12. Epinephrine delivery during neonatal resuscitation: comparison of direct endotracheal tube vs catheter inserted into endotracheal tube administration. Rehan, V.K., Garcia, M., Kao, J., Tucker, C.M., Patel, S.M. Journal of perinatology : official journal of the California Perinatal Association. (2004) [Pubmed]
  13. Increase of blood glucose concentrations in diabetic patients with glucagon eyedrops. Chuang, L.M., Wu, H.P., Chiou, G.C. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1992) [Pubmed]
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