Disease relevance of Fissure in Ano

• Topical glyceryl trinitrate may have a role in the treatment of anal fissure, haemorrhoids, certain types of constipation and anal pain [1].
• This report documents a therapeutic role for nitroglycerin, a nitric oxide donor, in the treatment of acutely thrombosed external hemorrhoids and anal fissure [2].

High impact information on Fissure in Ano

• A comparison of botulinum toxin and nitroglycerin ointment for chronic anal fissure [3].
• AGA technical review on the diagnosis and care of patients with anal fissure [4].
• Perianal abscess appeared to respond to sulfasalazine and anal fissure to prednisone or azathioprine [5].
• Topical nitrates potentiate the effect of botulinum toxin in the treatment of patients with refractory anal fissure [6].
• Pathophysiological aspects and clinical outcome of intra-anal application of isosorbide dinitrate in patients with chronic anal fissure [7].

Chemical compound and disease context of Fissure in Ano

• Oral nifedipine reduces resting anal pressure and heals chronic anal fissure [8].
• Topical diltiazem ointment in the treatment of chronic anal fissure [9].
• BACKGROUND: Topical application of L-arginine, the precursor of nitric oxide, reduces resting anal pressure without significant side-effects and may therefore be of benefit in the treatment of anal fissure [10].
• CONCLUSION: In the treatment of anal fissure the major effect of botulinum toxin on the IAS is blockade of sympathetic (noradrenaline mediated) neural output [11].
• The aim of this study was to test the efficacy of local application of nifedipine and lidocaine ointment in healing chronic anal fissure [12].

Anatomical context of Fissure in Ano

• CONCLUSIONS: Topical glyceryl trinitrate ointment and injection of botulinum toxin into the anal sphincter are advocated as the first-line treatment for chronic anal fissure [13].

Gene context of Fissure in Ano

• A series of 121 patients with chronic fissure-in-ano who underwent fissurectomy with superficial midline sphincterotomy was studied [14].
• CONCLUSION: It is proposed that alpha-1 adrenoceptor antagonists could be a suitable treatment for chronic anal fissure and other painful conditions where reduction in anal pressure is warranted [15].
• Practice parameters for the management of anal fissure. The Standards Task Force American Society of Colon and Rectal Surgeons [16].
• There were 2 patients with anal fissure who did not heal after left LAS [17].
• CONCLUSIONS: PMF 303 is able to decrease anal pressure in patients with anal fissure, to a similar extent to the widely tested (galenic) literature preparation [18].

Analytical, diagnostic and therapeutic context of Fissure in Ano

• METHODS: Anal manometry was performed on eight healthy volunteers and 15 patients with chronic anal fissure before and after oral administration of nifedipine 20 mg [19].
• CONCLUSIONS: Topical administration of a phosphodiesterase-5 inhibitor (sildenafil, Viagra) significantly reduces anal sphincter pressure in patients with chronic anal fissure [20].
• This review summarises current literature regarding topical nitroglycerin pharmacotherapy for anal fissure [21].
• AIMS: To compare, according to a randomized double-blind crossover study, the effects of a pharmaceutical preparation of a specific 0.2% glyceryl trinitrate ointment (PMF 303) and of the common preparation reported in the literature on the anal resting pressure in patients with anal fissure [18].

References