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MeSH Review

Fissure in Ano

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Disease relevance of Fissure in Ano


High impact information on Fissure in Ano


Chemical compound and disease context of Fissure in Ano


Anatomical context of Fissure in Ano


Gene context of Fissure in Ano

  • A series of 121 patients with chronic fissure-in-ano who underwent fissurectomy with superficial midline sphincterotomy was studied [14].
  • CONCLUSION: It is proposed that alpha-1 adrenoceptor antagonists could be a suitable treatment for chronic anal fissure and other painful conditions where reduction in anal pressure is warranted [15].
  • Practice parameters for the management of anal fissure. The Standards Task Force American Society of Colon and Rectal Surgeons [16].
  • There were 2 patients with anal fissure who did not heal after left LAS [17].
  • CONCLUSIONS: PMF 303 is able to decrease anal pressure in patients with anal fissure, to a similar extent to the widely tested (galenic) literature preparation [18].

Analytical, diagnostic and therapeutic context of Fissure in Ano


  1. 'Reversible chemical sphincterotomy' by local application of glyceryl trinitrate. Loder, P.B., Kamm, M.A., Nicholls, R.J., Phillips, R.K. The British journal of surgery. (1994) [Pubmed]
  2. Treatment of benign anal disease with topical nitroglycerin. Gorfine, S.R. Dis. Colon Rectum (1995) [Pubmed]
  3. A comparison of botulinum toxin and nitroglycerin ointment for chronic anal fissure. Vogel, J.D. N. Engl. J. Med. (1999) [Pubmed]
  4. AGA technical review on the diagnosis and care of patients with anal fissure. Madoff, R.D., Fleshman, J.W. Gastroenterology (2003) [Pubmed]
  5. National Cooperative Crohn's Disease Study: extraintestinal manifestations and perianal complications. Rankin, G.B., Watts, H.D., Melnyk, C.S., Kelley, M.L. Gastroenterology (1979) [Pubmed]
  6. Topical nitrates potentiate the effect of botulinum toxin in the treatment of patients with refractory anal fissure. Lysy, J., Israelit-Yatzkan, Y., Sestiery-Ittah, M., Weksler-Zangen, S., Keret, D., Goldin, E. Gut (2001) [Pubmed]
  7. Pathophysiological aspects and clinical outcome of intra-anal application of isosorbide dinitrate in patients with chronic anal fissure. Schouten, W.R., Briel, J.W., Boerma, M.O., Auwerda, J.J., Wilms, E.B., Graatsma, B.H. Gut (1996) [Pubmed]
  8. Oral nifedipine reduces resting anal pressure and heals chronic anal fissure. Brisinda, G., Maria, G. The British journal of surgery. (2000) [Pubmed]
  9. Topical diltiazem ointment in the treatment of chronic anal fissure. Knight, J.S., Birks, M., Farouk, R. The British journal of surgery. (2001) [Pubmed]
  10. L-arginine-induced relaxation of the internal anal sphincter is not mediated by nitric oxide. Acheson, A.G., Griffin, N., Scholefield, J.H., Wilson, V.G. The British journal of surgery. (2003) [Pubmed]
  11. Mechanism of action of botulinum toxin on the internal anal sphincter. Jones, O.M., Brading, A.F., Mortensen, N.J. The British journal of surgery. (2004) [Pubmed]
  12. Topical nifedipine with lidocaine ointment vs. active control for treatment of chronic anal fissure: results of a prospective, randomized, double-blind study. Perrotti, P., Bove, A., Antropoli, C., Molino, D., Antropoli, M., Balzano, A., De Stefano, G., Attena, F. Dis. Colon Rectum (2002) [Pubmed]
  13. Concepts in pathogenesis and treatment of chronic anal fissure--a review of the literature. Utzig, M.J., Kroesen, A.J., Buhr, H.J. Am. J. Gastroenterol. (2003) [Pubmed]
  14. Fissurectomy with superficial midline sphincterotomy. A viable alternative for the surgical correction of chronic fissure/ulcer-in-ano. Bode, W.E., Culp, C.E., Spencer, R.J., Beart, R.W. Dis. Colon Rectum (1984) [Pubmed]
  15. Alpha-1 adrenoceptor blockade: potential new treatment for anal fissures. Pitt, J., Craggs, M.M., Henry, M.M., Boulos, P.B. Dis. Colon Rectum (2000) [Pubmed]
  16. Practice parameters for the management of anal fissure. The Standards Task Force American Society of Colon and Rectal Surgeons. Rosen, L., Abel, M.E., Gordon, P.H., Denstman, F.J., Fleshman, J.W., Hicks, T.C., Huber, P.J., Kennedy, H.L., Levin, S.E., Nicholson, J.D. Dis. Colon Rectum (1992) [Pubmed]
  17. Anal manometry in patients with fissure-in-ano before and after internal sphincterotomy. Xynos, E., Tzortzinis, A., Chrysos, E., Tzovaras, G., Vassilakis, J.S. International journal of colorectal disease. (1993) [Pubmed]
  18. Double-blind manometric assessment of two topical glyceryl trinitrate formulations in patients with chronic anal fissures. Bassotti, G., Clementi, M., Ceccarelli, F., Pelli, M.A. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. (2000) [Pubmed]
  19. Oral nifedipine reduces resting anal pressure and heals chronic anal fissure. Cook, T.A., Humphreys, M.M., McC Mortensen, N.J. The British journal of surgery. (1999) [Pubmed]
  20. Manometric study of topical sildenafil (Viagra) in patients with chronic anal fissure: sildenafil reduces anal resting tone. Torrabadella, L., Salgado, G., Burns, R.W., Berman, I.R. Dis. Colon Rectum (2004) [Pubmed]
  21. Treatment of anal fissures with topical nitroglycerin. Ehrenpreis, E.D., Rubin, D.T., Ginsburg, P.M., Meyers, J.S. Expert opinion on pharmacotherapy. (2001) [Pubmed]
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