Disease relevance of Otosclerosis

• These findings suggest that the collagenase and prostaglandin synthetase being produced by macrophages, fibroblasts, and osteoclasts are also involved in the processes of bone resorption in otospongiosis [1].
• These data strongly support the hypothesis of a measles virus involvement in otosclerosis and may reflect a decreased incidence of otosclerosis in the generation of patients vaccinated against measles virus [2].
• A high-resolution computed tomography (HRCT) study on 55 patients with surgically confirmed clinical otosclerosis confirms the existence of cochlear otospongiosis among the Chinese. Positive radiographic results of cochlear otospongiosis (13 ears, 12%) were found in patients with mixed-type deafness but in none with conductive hearing loss [3].
• Further experiences with moderate dosage sodium fluoride for sensorineural hearing loss, tinnitus and vertigo due to otospongiosis [4].

High impact information on Otosclerosis

• Otosclerosis? Otospongiosis? What's in a name [5]?
• The effect of sodium fluoride treatment in patients with otospongiosis has been evaluated in a prospective clinical double-blind, placebo-controlled study of 95 patients [6].
• Clinical studies on fluoride in otospongiosis [7].
• These findings indicate that stapedial involvement is common in patients thought to have pure sensorineural otosclerosis [8].
• Otospongiosis is well shown by CT which gives a good predicator of luminal patency [9].

Chemical compound and disease context of Otosclerosis

• It has already been attempted to use Ipriflavone medical treatment of otosclerosis [10].
• Ipriflavon, an isoflavone derivative of therapeutical potential in otosclerosis, also reduced the PCS in 1, 10 and 50 microM concentrations [11].
• Celloidin sections stored in 80% alcohol with active lesions of cochlear otospongiosis were processed and re-embedded in epoxy resin [12].

Biological context of Otosclerosis

• We investigated the acoustic reflex responses in a group of patients diagnosed as sensorineural otosclerosis and compared these reflex findings with the findings in patients with confirmed otosclerosis but with a minimal conductive impairment [8].

Anatomical context of Otosclerosis

• Failure of remodeling of newly formed vascular, woven bone (otospongiosis) results in sclerotic bone (otosclerosis) with abnormal osteons [13].
• Test and teach. Number thirty-three. Diagnosis: otosclerosis (otospongiosis) in an active phase involving the stapial footplate and the medial portions of both stapes crura [14].
• Several theories have been advanced to explain the sensorineural hearing loss that occurs in patients with otospongiosis: toxic substances produced by the otospongiotic focus; vascular shunts betwen the inner ear vessels and the otospongiotic focus; and atrophy of the organ of Corti and stria vascularis due to unknown causes [15].

Gene context of Otosclerosis

• It will be demonstrated that such therapy is beneficial not only in controlling the progressive sensorineural hearing loss but also the symptoms of vestibular dysfunction in patients with cochlear otosclerosis (otospongiosis) [16].
• On the basis of very low P-values, replication in an independent population and a functional effect of the protective variant, we conclude that TGF-beta1 influences the susceptibility for otosclerosis, and that the I263 variant is protective against the disease [17].

References