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MeSH Review


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Disease relevance of Otosclerosis


High impact information on Otosclerosis


Chemical compound and disease context of Otosclerosis


Biological context of Otosclerosis


Anatomical context of Otosclerosis


Gene context of Otosclerosis

  • It will be demonstrated that such therapy is beneficial not only in controlling the progressive sensorineural hearing loss but also the symptoms of vestibular dysfunction in patients with cochlear otosclerosis (otospongiosis) [16].
  • On the basis of very low P-values, replication in an independent population and a functional effect of the protective variant, we conclude that TGF-beta1 influences the susceptibility for otosclerosis, and that the I263 variant is protective against the disease [17].


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  3. Radiographically confirmed cochlear otospongiosis among the Chinese. Huang, T.S., Lee, F.P., Chen, L.K. The Annals of otology, rhinology, and laryngology. (1991) [Pubmed]
  4. Further experiences with moderate dosage sodium fluoride for sensorineural hearing loss, tinnitus and vertigo due to otospongiosis. Shambaugh, G.E. Adv. Otorhinolaryngol. (1977) [Pubmed]
  5. Otosclerosis? Otospongiosis? What's in a name? Gunby, P. JAMA (1979) [Pubmed]
  6. Otospongiosis and sodium fluoride. A clinical double-blind, placebo-controlled study on sodium fluoride treatment in otospongiosis. Bretlau, P., Salomon, G., Johnsen, N.J. The American journal of otology. (1989) [Pubmed]
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  8. Cochlear otosclerosis: acoustic reflex findings. Forquer, B.D., Sheehy, J.L. The American journal of otology. (1981) [Pubmed]
  9. Imaging for cochlear implants. Phelps, P.D., Proops, D.W. The Journal of laryngology and otology. Supplement. (1999) [Pubmed]
  10. Flavonoids alter bone-remodelling in auditory ossicle organ cultures. Sziklai, I., Ribári, O. Acta Otolaryngol. (1995) [Pubmed]
  11. Effect of flavonoid on PGE2-induced alterations in percentage collagen synthesis in ossicle organ cultures. Ribári, O., Sziklai, I. Acta Otolaryngol. (1987) [Pubmed]
  12. Ultrastructural characterization of otospongiotic lesions in re-embedded celloidin sections. McKenna, M., Gadre, A.K., Rask-Andersen, H. Acta Otolaryngol. (1990) [Pubmed]
  13. Pathology of otosclerosis: a review. Davis, G.L. American journal of otolaryngology. (1987) [Pubmed]
  14. Test and teach. Number thirty-three. Diagnosis: otosclerosis (otospongiosis) in an active phase involving the stapial footplate and the medial portions of both stapes crura. Iyer, P.V., Gristwood, R.E. Pathology. (1982) [Pubmed]
  15. Sensorineural hearing loss due to cochlear otospongiosis: theoretical considerations of etiology. Linthicum, F.H., Filipo, R., Brody, S. The Annals of otology, rhinology, and laryngology. (1975) [Pubmed]
  16. Otosclerosis and vestibular dysfunction. Freeman, J. Laryngoscope (1980) [Pubmed]
  17. The coding polymorphism T263I in TGF-beta1 is associated with otosclerosis in two independent populations. Thys, M., Schrauwen, I., Vanderstraeten, K., Janssens, K., Dieltjens, N., Van Den Bogaert, K., Fransen, E., Chen, W., Ealy, M., Claustres, M., Cremers, C.R., Dhooge, I., Declau, F., Claes, J., Van de Heyning, P., Vincent, R., Somers, T., Offeciers, E., Smith, R.J., Van Camp, G. Hum. Mol. Genet. (2007) [Pubmed]
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