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Chemical Compound Review

Iprosten     3-phenyl-7-propan-2-yloxy- chromen-4-one

Synonyms: Osteofix, Quinogin, Yambolap, Osteochin, Osteoquine, ...
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Disease relevance of Yambolap


Psychiatry related information on Yambolap

  • Risk reduction of osteoporosis can be enhanced specifically through the use of ipriflavone and a comprehensive "bone building" vitamin and mineral program [4].

High impact information on Yambolap


Chemical compound and disease context of Yambolap


Biological context of Yambolap


Anatomical context of Yambolap


Associations of Yambolap with other chemical compounds


Gene context of Yambolap


Analytical, diagnostic and therapeutic context of Yambolap


  1. Ipriflavone in the treatment of postmenopausal osteoporosis: a randomized controlled trial. Alexandersen, P., Toussaint, A., Christiansen, C., Devogelaer, J.P., Roux, C., Fechtenbaum, J., Gennari, C., Reginster, J.Y. JAMA (2001) [Pubmed]
  2. The effect of ipriflavone (TC-80) on bone resorption in tissue culture. Tsuda, M., Kitazaki, T., Ito, T., Fujita, T. J. Bone Miner. Res. (1986) [Pubmed]
  3. Efficacy of ipriflavone in preventing adverse effects of leuprolide. Somekawa, Y., Chiguchi, M., Ishibashi, T., Wakana, K., Aso, T. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  4. Alternative therapies for menopause. Kass-Annese, B. Clinical obstetrics and gynecology. (2000) [Pubmed]
  5. Mechanism of increased coxsackie and adenovirus receptor gene expression and adenovirus uptake by phytoestrogen and histone deacetylase inhibitor in human bladder cancer cells and the potential clinical application. Pong, R.C., Roark, R., Ou, J.Y., Fan, J., Stanfield, J., Frenkel, E., Sagalowsky, A., Hsieh, J.T. Cancer Res. (2006) [Pubmed]
  6. Advanced glycation end products enhance osteoclast-induced bone resorption in cultured mouse unfractionated bone cells and in rats implanted subcutaneously with devitalized bone particles. Miyata, T., Notoya, K., Yoshida, K., Horie, K., Maeda, K., Kurokawa, K., Taketomi, S. J. Am. Soc. Nephrol. (1997) [Pubmed]
  7. Effect of ipriflavone on expression of markers characteristic of the osteoblast phenotype in rat bone marrow stromal cell culture. Notoya, K., Yoshida, K., Tsukuda, R., Taketomi, S. J. Bone Miner. Res. (1994) [Pubmed]
  8. Novel ipriflavone receptors coupled to calcium influx regulate osteoclast differentiation and function. Miyauchi, A., Notoya, K., Taketomi, S., Takagi, Y., Fujii, Y., Jinnai, K., Takahashi, K., Chihara, K., Fujita, T. Endocrinology (1996) [Pubmed]
  9. Prevention of early postmenopausal bone loss using low doses of conjugated estrogens and the non-hormonal, bone-active drug ipriflavone. Agnusdei, D., Gennari, C., Bufalino, L. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (1995) [Pubmed]
  10. Similarities and differences between the effects of ipriflavone and vitamin K on bone resorption and formation in vitro. Notoya, K., Yoshida, K., Shirakawa, Y., Taketomi, S., Tsuda, M. Bone (1995) [Pubmed]
  11. Effects of ipriflavone and its metabolites on a clonal osteoblastic cell line. Benvenuti, S., Tanini, A., Frediani, U., Bianchi, S., Masi, L., Casano, R., Bufalino, L., Serio, M., Brandi, M.L. J. Bone Miner. Res. (1991) [Pubmed]
  12. Legumes and soybeans: overview of their nutritional profiles and health effects. Messina, M.J. Am. J. Clin. Nutr. (1999) [Pubmed]
  13. Ipriflavone inhibits osteolytic bone metastasis of human breast cancer cells in a nude mouse model. Iwasaki, T., Mukai, M., Tsujimura, T., Tatsuta, M., Nakamura, H., Terada, N., Akedo, H. Int. J. Cancer (2002) [Pubmed]
  14. Ipriflavone as an inhibitor of human cytochrome P450 enzymes. Monostory, K., Vereczkey, L., Lévai, F., Szatmári, I. Br. J. Pharmacol. (1998) [Pubmed]
  15. Effects of ipriflavone on calcitonin synthesis in C cells of the rat thyroid. Watanabe, K., Takekoshi, S., Kakudo, K. Calcif. Tissue Int. (1992) [Pubmed]
  16. Increase in femoral bone mass by ipriflavone alone and in combination with 1 alpha-hydroxyvitamin D3 in growing rats with skeletal unloading. Notoya, K., Yoshida, K., Tsukuda, R., Taketomi, S., Tsuda, M. Calcif. Tissue Int. (1996) [Pubmed]
  17. Effects of ipriflavone on perialveolar bone formation. Martini, M., Formigli, L., Tonelli, P., Giannelli, M., Amunni, F., Naldi, D., Brandi, M.L., Zecchi Orlandini, S., Orlandini, G.E. Calcif. Tissue Int. (1998) [Pubmed]
  18. Ipriflavone inhibits murine osteoclast formation in vitro. Morita, I., Sakaguchi, K., Kurachi, T., Murota, S. Calcif. Tissue Int. (1992) [Pubmed]
  19. Stimulatory effect of ipriflavone on formation of bone-like tissue in rat bone marrow stromal cell culture. Notoya, K., Tsukuda, R., Yoshida, K., Taketomi, S. Calcif. Tissue Int. (1992) [Pubmed]
  20. Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous ipriflavone in rats. Chung, H.J., Choi, Y.H., Kim, S.H., Lee, M.G. J. Pharm. Pharmacol. (2006) [Pubmed]
  21. Culture of stromal cells derived from medullary cavity of human long bone in the presence of 1,25-dihydroxyvitamin D3, recombinant human bone morphogenetic protein-2, or ipriflavone. Shibano, K., Watanabe, J., Iwamoto, M., Ogawa, R., Kanamura, S. Bone (1998) [Pubmed]
  22. Effect of ipriflavone--a synthetic derivative of natural isoflavones--on bone mass loss in the early years after menopause. Gennari, C., Agnusdei, D., Crepaldi, G., Isaia, G., Mazzuoli, G., Ortolani, S., Bufalino, L., Passeri, M. Menopause (New York, N.Y.) (1998) [Pubmed]
  23. Effects of ipriflavone on bone loss following a bilateral ovariectomy and menopause: a randomized placebo-controlled study. Katase, K., Kato, T., Hirai, Y., Hasumi, K., Chen, J.T. Calcif. Tissue Int. (2001) [Pubmed]
  24. Binding and bioeffects of Ipriflavone on a human preosteoclastic cell line. Benvenuti, S., Petilli, M., Frediani, U., Tanini, A., Fiorelli, G., Bianchi, S., Bernabei, P.A., Albanese, C., Brandi, M.L. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
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