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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Reflex, Acoustic

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Disease relevance of Reflex, Acoustic

  • Our review of the recent literature, however, failed to identify any publication on the use of ABR and acoustic reflex testing in the pediatric neurofibromatosis population [1].
  • Comparisons were made of the ABR latencies of tinnitus (T) and nontinnitus (NT) patient groups balanced for age and gender and matched for acoustic reflex threshold (ART)s, 1000 to 4000 Hz and 4000 Hz auditory thresholds, and normal hearing [2].
  • In summary, we found: 1) speech-in-noise results were of some value in those patients with normal hearing and of no value in those patients with hearing loss, 2) the acoustic reflex test gave misleading information in 25% of patients, and 3) the ABR test proved to be the most effective test in separating tumor and non-tumor patients [3].
  • The hyperacusis and hearing loss in WS may stem from a deficiency in the acoustic reflex resulting from auditory nerve dysfunction [4].
  • Contralateral and ipsilateral acoustic reflex activity, and the Pa component of the AMR, were not observed in barbiturate coma, and reappeared with the emergence of brainstem neurologic signs [5].

Psychiatry related information on Reflex, Acoustic


High impact information on Reflex, Acoustic

  • Acoustic reflex abnormalities in cranial-cervical dystonia [7].
  • PROCEDURES: Tympanometry and acoustic reflex testing were performed on 27 mixed-breed and purebred dogs under isoflurane anesthesia in a non-sound-attenuated room and 21 Beagles under sedation in a sound-attenuated room [8].
  • OBJECTIVE: The sensitivity of acoustic reflex threshold changes for monitoring cisplatin ototoxicity in children was compared with the sensitivity of conventional audiometric tests [9].
  • Advanced cases present features of retrocochlear affection with decreasing speech recognition, elevated acoustic reflex thresholds, and increased ABR latency with derangement of potentials [10].
  • Observations on the acoustic reflex threshold in institutionalized retarded adults taking mellaril and/or thorazine [11].

Biological context of Reflex, Acoustic


Anatomical context of Reflex, Acoustic


Associations of Reflex, Acoustic with chemical compounds


Gene context of Reflex, Acoustic

  • However, current findings suggest that ABR and acoustic reflex studies are always indicated in the pediatric NF2 population and are as valid and significant as in adults with NF2 [17].
  • The clinical interpretation of acoustic reflex test results in ears with sensorineural impairment should be based on a consideration of three characteristics of the response: the reflex threshold hearing level, the reflex threshold sensation level, and the decay of the reflex [18].
  • The presence of acoustic reflex patterns classically associated with stapedial otosclerosis in patients with cochlear otosclerosis leads us to predict that some degree of stapedial fixation is common in many cases of cochlear otosclerosis [19].
  • The relationships between properties of the acoustic reflex and temporary threshold shift (TTS) were examined in eight subjects exposed to a 95 dB SPL, 1.0-kHz octave-band noise for 4 h [20].
  • The results indicated that MS subjects exhibited response abnormalities including prolonged rise times of the acoustic reflex and prolonged absolute latencies, interwave latencies and interaural latencies, and poor response stability of the ABR [21].


  1. Neuroaudiologic abnormalities in patients with type 1 neurofibromatosis. Pensak, M.L., Keith, R.W., Dignan, P.S., Stowens, D.W., Towbin, R.B., Katbamna, B. Laryngoscope (1989) [Pubmed]
  2. The effect of tinnitus on ABR latencies. Ikner, C.L., Hassen, A.H. Ear and hearing. (1990) [Pubmed]
  3. Cerebellopontine angle lesions: an audiological test protocol. Cashman, M.Z., Rossman, R.N., Nedzelski, J.M. The Journal of otolaryngology. (1983) [Pubmed]
  4. Hyperacusis in Williams syndrome: characteristics and associated neuroaudiologic abnormalities. Gothelf, D., Farber, N., Raveh, E., Apter, A., Attias, J. Neurology (2006) [Pubmed]
  5. The effects of high-dose barbiturates on the acoustic reflex and auditory evoked responses. Two case reports. Hall, J.W. Acta Otolaryngol. (1985) [Pubmed]
  6. Acceptable noise level, phoneme recognition in noise, and measures of auditory efferent activity. Harkrider, A.W., Smith, S.B. Journal of the American Academy of Audiology. (2005) [Pubmed]
  7. Acoustic reflex abnormalities in cranial-cervical dystonia. Lew, H., Jordan, C., Jerger, J., Jankovic, J. Neurology (1992) [Pubmed]
  8. Impedance audiometric measurements in clinically normal dogs. Cole, L.K., Podell, M., Kwochka, K.W. Am. J. Vet. Res. (2000) [Pubmed]
  9. The utility of acoustic reflex thresholds and other conventional audiologic tests for monitoring cisplatin ototoxicity in the pediatric population. Park, K.R. Ear and hearing. (1996) [Pubmed]
  10. Audiologic findings in a family with mitochondrial disorder. Elverland, H.H., Torbergsen, T. The American journal of otology. (1991) [Pubmed]
  11. Observations on the acoustic reflex threshold in institutionalized retarded adults taking mellaril and/or thorazine. Niswander, P.S., Helfner-Mitchell, F. Ear and hearing. (1988) [Pubmed]
  12. Effects of xylazine and ketamine on the acoustic reflex and brain stem auditory-evoked response in the cat. Sims, M.H., Horohov, J.E. Am. J. Vet. Res. (1986) [Pubmed]
  13. Diagnostic vetting of individuals with asymmetric sensorineural hearing impairments. Swan, I.R. The Journal of laryngology and otology. (1989) [Pubmed]
  14. Effects of ethyl alcohol on the acoustic reflex threshold. Cohill, E.N., Greenberg, H.J. Journal of the American Audiology Society. (1977) [Pubmed]
  15. Calibration of ipsilateral stimulus transducer for acoustic reflex measurements. Olsen, S., Osterhammel, P.A., Rasmussen, A.N., Nielsen, L.H. Scandinavian audiology. (1995) [Pubmed]
  16. The effect of flunitrazepam on acoustic reflex--a methodological pilot study. Salonen, M., Laurikainen, E., Sipilä, J., Johansson, R., Kanto, J. Methods and findings in experimental and clinical pharmacology. (1988) [Pubmed]
  17. Pediatric audiologic profile in type 1 and type 2 neurofibromatosis. Pikus, A.T. Journal of the American Academy of Audiology. (1995) [Pubmed]
  18. The acoustic reflex test in cochlear and eighth nerve pathology ears. Sanders, J.W., Josey, A.F., Glasscock, M.E., Jackson, C.G. Laryngoscope (1981) [Pubmed]
  19. The negative on/off effect in cochlear and early stapedial otosclerosis. Forquer, B.D., Sheehy, J.L. Ear and hearing. (1981) [Pubmed]
  20. Acoustic-reflex activity and behavioral thresholds following exposure to noise. Gerhardt, K.J., Hepler, E.L. The Journal of the Acoustical Society of America. (1983) [Pubmed]
  21. Acoustic reflex dynamics and auditory brain stem responses in multiple sclerosis. Keith, R.W., Garza-Holquin, Y., Smolak, L., Pensak, M.L. The American journal of otology. (1987) [Pubmed]
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