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MeSH Review

Syphilis, Latent

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Disease relevance of Syphilis, Latent

  • Although ceftriaxone achieves high serum and CSF levels, 10 to 14 days of treatment with this drug were associated with a 23% failure rate in HIV-infected patients who had latent syphilis or asymptomatic neurosyphilis [1].
  • Three doses of benzathine penicillin did not have a significantly higher relapse rate and may provide appropriate therapy, at least for documented latent syphilis in persons co-infected with HIV [1].
  • Thirteen patients received benzathine penicillin for presumed latent syphilis; results were similar to those observed after ceftriaxone therapy, with 8 (62%) responders, 1 (8%) serofast, 2 (15%) relapses, and 2 (15%) failures [1].
  • The goal of this study was to estimate the prevalence of newly diagnosed latent syphilis, as well as previously treated syphilis, in emergency department patients giving a history of cocaine use [2].

High impact information on Syphilis, Latent


Chemical compound and disease context of Syphilis, Latent


Anatomical context of Syphilis, Latent


Gene context of Syphilis, Latent

  • In a secondary analysis, a drop in CD4 count (21%) among those with early latent syphilis was observed compared with controls [11].

Analytical, diagnostic and therapeutic context of Syphilis, Latent


  1. Response of latent syphilis or neurosyphilis to ceftriaxone therapy in persons infected with human immunodeficiency virus. Dowell, M.E., Ross, P.G., Musher, D.M., Cate, T.R., Baughn, R.E. Am. J. Med. (1992) [Pubmed]
  2. High syphilis rates among cocaine abusers identified in an emergency department. Ernst, A.A., Martin, D.H. Sexually transmitted diseases. (1993) [Pubmed]
  3. Antigens of Treponema pallidum recognized by IgG and IgM antibodies during syphilis in humans. Baker-Zander, S.A., Hook, E.W., Bonin, P., Handsfield, H.H., Lukehart, S.A. J. Infect. Dis. (1985) [Pubmed]
  4. Evaluation of neurosyphilis in human immunodeficiency virus-infected individuals. Tomberlin, M.G., Holtom, P.D., Owens, J.L., Larsen, R.A. Clin. Infect. Dis. (1994) [Pubmed]
  5. Asymptomatic neurosyphilis after doxycycline therapy for early latent syphilis. Zenilman, J.M., Rand, S., Barditch, P., Rompalo, A.M. Sexually transmitted diseases. (1993) [Pubmed]
  6. Surface immunofluorescence assay for diagnosis of Lyme disease. Cevenini, R., Sambri, V., Massaria, F., Franchini, R., D'Antuono, A., Borda, G., Negosanti, M. J. Clin. Microbiol. (1992) [Pubmed]
  7. Treatment of early latent syphilis of less than a year's duration: an evaluation of 275 cases. Fiumara, N.J. Sexually transmitted diseases. (1978) [Pubmed]
  8. Treatment of latent syphilis in HIV-infected patients with 10 d of benzylpenicillin G benethamine: a prospective study in Maputo, Mozambique. Tattevin, P., Renault, P., Joly, V., Bastos, R., Coelho, E., Adda, C., Ebel, A., Yeni, P. Scand. J. Infect. Dis. (2002) [Pubmed]
  9. Treatment of secondary recurrent and early latent syphilis with penicillin and ethamide: clinical and experimental evaluation. Mordovtsev, V.N., Bednova, V.N., Nazarova, A.J. Dermatologische Monatschrift. (1987) [Pubmed]
  10. Interleukin 10 and its role in the regulation of the cell-mediated immune response in syphilis. Lusiak, M., Podwińska, J. Arch. Immunol. Ther. Exp. (Warsz.) (2001) [Pubmed]
  11. The effects of early syphilis on CD4 counts and HIV-1 RNA viral loads in blood and semen. Sadiq, S.T., McSorley, J., Copas, A.J., Bennett, J., Edwards, S.J., Kaye, S., Kirk, S., French, P., Weller, I.V. Sexually transmitted infections. (2005) [Pubmed]
  12. Neurosyphilis after treatment of latent syphilis with benzathine penicillin. Jørgensen, J., Tikjøb, G., Weismann, K. Genitourinary medicine. (1986) [Pubmed]
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