Disease relevance of Syphilis, Latent

• Although ceftriaxone achieves high serum and CSF levels, 10 to 14 days of treatment with this drug were associated with a 23% failure rate in HIV-infected patients who had latent syphilis or asymptomatic neurosyphilis [1].
• Three doses of benzathine penicillin did not have a significantly higher relapse rate and may provide appropriate therapy, at least for documented latent syphilis in persons co-infected with HIV [1].
• Thirteen patients received benzathine penicillin for presumed latent syphilis; results were similar to those observed after ceftriaxone therapy, with 8 (62%) responders, 1 (8%) serofast, 2 (15%) relapses, and 2 (15%) failures [1].
• The goal of this study was to estimate the prevalence of newly diagnosed latent syphilis, as well as previously treated syphilis, in emergency department patients giving a history of cocaine use [2].

High impact information on Syphilis, Latent

• Sera from patients with secondary and early latent syphilis uniformly demonstrated reactivity to 22 separate polypeptide antigens; decreased reactivity was seen in late latent syphilis [3].
• We examined the use of the Treponema pallidum hemagglutination (TPHA) index and quantitative tests of CSF by means of microhemagglutination-T. pallidum for diagnosis of neurosyphilis in 58 HIV-infected persons with latent syphilis who had not recently received therapy for syphilis [4].
• Asymptomatic neurosyphilis after doxycycline therapy for early latent syphilis [5].
• These data suggest that elicitation of a history of cocaine use from urban hospital emergency department patients may be helpful in identifying patients with latent syphilis [2].
• SIFA was found to be highly specific, since sera from all patients with secondary or latent syphilis and patients with rheumatoid arthritis did not react in the test [6].

Chemical compound and disease context of Syphilis, Latent

• A 50-year-old woman allergic to penicillin with early latent syphilis was treated with two courses of doxycycline [5].
• The author's recommended treatment for early latent syphilis of less than a year's duration is im administration of benzathine penicillin G, 2.4 million units weekly for two consecutive weeks [7].
• Two hundred seventy-five patients who had early latent syphilis of less than a year's duration were treated with these regimens; of these, 252 were given benzathine penicillin G, and 23 received tetracycline [7].
• Treatment of latent syphilis in HIV-infected patients with 10 d of benzylpenicillin G benethamine: a prospective study in Maputo, Mozambique [8].
• Treatment of secondary recurrent and early latent syphilis with penicillin and ethamide: clinical and experimental evaluation [9].

Anatomical context of Syphilis, Latent

• It has also been demonstrated that in late latent syphilis, when Th1 lymphocytes are not able to produce IL-2 and IFN, the cells are able to produce only IL-12 and NO [10].

Gene context of Syphilis, Latent

• In a secondary analysis, a drop in CD4 count (21%) among those with early latent syphilis was observed compared with controls [11].

Analytical, diagnostic and therapeutic context of Syphilis, Latent

• Neurosyphilis after treatment of latent syphilis with benzathine penicillin [12].

References