Disease relevance of Toxocariasis

• Meningomyelitis in a case of toxocariasis with markedly isolated CSF eosinophilia and an MRI-documented thoracic cord lesion [1].
• The most common preexisting ocular disease included intermediate uveitis (pars planitis) in eight eyes (28%), retinitis pigmentosa in six (21%), toxoplasmic retinitis in two (7%), toxocariasis in two (7%), retinochoroidal coloboma in two (7%), and traumatic chorioretinopathy in two (7%) [2].
• Therapy of ocular toxocariasis is primarily based upon corticosteroids use, when visceral larva migrans and few cases of common or covert toxocariasis can be treated by anthelmintics whose the most efficient appeared to be diethylcarbamazine [3].
• Sera from 54 Brazilian children with a history of tropical eosinophilia syndrome were screened for toxocariasis [4].
• The clinical features of the 'Palm Island mystery disease' cannot be explained on the basis of toxocariasis, nor do they correlate with the known manifestations of algal toxicity [5].

High impact information on Toxocariasis

• Mebendazole in toxocariasis [6].
• Lafoensia pacari extract inhibits IL-5 production in toxocariasis [7].
• CONCLUSIONS: These data suggest, first, that patients presenting unexplained allergic syndromes should be checked for helminthiases, even if blood eosinophilia is lacking, and, second, in such subjects displaying positive toxocariasis immunodiagnosis, ECP assessment would be a useful marker to distinguish between active and past toxocaral disease [8].
• Sera from mice infected with the parasite also contained antibodies to rTc-CPL-1 as did sera from nine patients with proven toxocariasis; control sera did not [9].
• These results suggest that MMP-9 may be associated with the inflammatory reaction to larval toxocariasis during early migration, and may therefore be a useful marker during T. canis larvae migration [10].

Chemical compound and disease context of Toxocariasis

• "Covert toxocariasis" in a child treated with low-dose diethylcarbamazine [11].
• Treatment of ocular toxocariasis with albendazole [12].
• Anthelmintic effect of levamisole hydrochloride or ivermectin on tissue toxocariasis of mice [13].
• The effect of cyclosporin A (CSA) on murine visceral toxocariasis canis [14].
• Benzimidazole carbamates (mebendazole, albendazole and fenbendazole) are the most commonly used anthelmintic drugs for the treatment of larval toxocariasis (Toxocara canis) in paratenic hosts [15].

Biological context of Toxocariasis

• Antibody responses to Toxocara canis using sera from parasite-infected mice and protection from toxocariasis by immunisation with ES antigens [16].
• When the test was performed on sera from healthy individuals and those with other parasitic infections, cross-reactions were observed only with sera from patients with toxocariasis (1/8), Chagas' disease (3/17) and four out of 100 healthy individuals [17].

Gene context of Toxocariasis

• Toxocariasis. A possible cause of the Palm Island mystery disease [18].
• For human population IACE was evaluated using sera from 440 patients with clinical signs of toxocariasis and the cut-off value was established with 60 serum samples from apparently healthy individuals [19].
• This case illustrates that toxocariasis should be considered as a rare differential diagnostic possibility for multiple liver lesions and multifocal peripheral pulmonary opacities in young children with Wilms tumor [20].

Analytical, diagnostic and therapeutic context of Toxocariasis

• Enzyme-linked immunosorbent assay for toxocariasis, its application to the sera of children [21].

References